Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: A cutting device for cutting a pipe having a pipe wall. The cutting device includes an elongate carrier having a tool end which is engageable with a power tool and an opposed free end. The device includes a guide wheel located at the free end of the carrier which is loosely mounted thereon for rotation relative thereto, having a bearing surface extending parallel to a longitudinal axis of the carrier. The device also includes a cutting element having a peripheral cutting edge which is located adjacent to the guide wheel being positioned intermediate the guide wheel and the tool end. The cutting element is of greater transverse dimension than the guide wheel so that when the bearing surface bears against an internal surface of the pipe the distance between the cutting edge of the cutting element and the bearing surface enables the cutting element to cut through the pipe wall.

Abstract: A multi-functional slurry processing system (“VARCOR”) and associated methods is disclosed. The present examples provide a multi-functional slurry processing system incorporating systems and methods for separating liquid and solid components in slurries. In particular the systems and methods described herein produce clean water, dried solids, and potential concentration of desirable constituents with a boiling point lower than water. At least one example of the multi-functional slurry processing system provides a self-contained processing facility configured to efficiently convert high water-content slurries into its constituent solid and liquid fractions and subsequently generating and collecting clean water and concentrating desirable constituents with a boiling point lower than water.

Abstract: A multi-functional slurry processing system (“VARCOR”) and associated methods is disclosed. The present examples provide a multi-functional slurry processing system incorporating systems and methods for separating liquid and solid components in slurries. In particular the systems and methods described herein produce clean water, dried solids, and potential concentration of desirable constituents with a boiling point lower than water. At least one example of the multi-functional slurry processing system provides a self-contained processing facility configured to efficiently convert high water-content slurries into its constituent solid and liquid fractions and subsequently generating and collecting clean water and concentrating desirable constituents with a boiling point lower than water.

Abstract: A multi-functional slurry processing system (“VARCOR”) and associated methods is disclosed. The present examples provide a multi-functional slurry processing system incorporating systems and methods for separating liquid and solid components in slurries. In particular the systems and methods described herein produce clean water, dried solids, and potential concentration of desirable constituents with a boiling point lower than water. At least one example of the multi-functional slurry processing system provides a self-contained processing facility configured to efficiently convert high water-content slurries into its constituent solid and liquid fractions and subsequently generating and collecting clean water and concentrating desirable constituents with a boiling point lower than water.

Abstract: It is technically feasible to take existing insulator sleeves that are common at establishments selling hot beverages in paper coffee cups and turn them upside down. It is also feasible to place paper coffee cups onto the upside down insulator sleeve. The invention is to use insulator sleeves upside down for paper coffee cups. Using the insulator sleeve upside down provides a base when on a flat surface and a stable contact so the sleeve cannot fall off when on a flat surface. Carrying the two together is no harder than the current use of insulator sleeves. A benefit to advertisers is the upside down insulation sleeve aims the advertising message up toward human sight where the current usage has the advertising pointing down toward the ground.

Abstract: A drawn glass-coated metallic member has a thermal contraction coefficient differential such that the thermal contraction coefficient of the glass is less than that of the metallic member. The thermal contraction coefficient differential is maintained within a predetermined range during drawing. Drawn glass is placed under residual compression, interfacial bonding between said glass and said wire is substantially uniform, and surface cracking and bond breaks between metal and glass are substantially prevented. Optical properties of the glass coated microwire provide a basis for enabling multi-bit encoding capability. Advantageously data encoding is achieved optically, magneto-optically or using a combined magnetic and optical encoding mechanism. The duplex material constitution of the glass coated microwire permits imparting of data thereon by selection and processing of the glass. Data implantation is readily achieved in-line, during an initial drawing operation, or as a separate post-draw process.

Abstract: A drawn glass-coated metallic member has a thermal contraction coefficient differential such that the thermal contraction coefficient of the glass is less than that of the metallic member. The thermal contraction coefficient differential is maintained within a predetermined range during drawing. Drawn glass is placed under residual compression, interfacial bonding between said glass and said wire is substantially uniform, and surface cracking and bond breaks between metal and glass are substantially prevented. Optical properties of the glass coated microwire provide a basis for enabling multi-bit encoding capability. Advantageously data encoding is achieved optically, magneto-optically or using a combined magnetic and optical encoding mechanism. The duplex material constitution of the glass coated microwire permits imparting of data thereon by selection and processing of the glass. Data implantation is readily achieved in-line, during an initial drawing operation, or as a separate post-draw process.

Abstract: A metallic glass-coated wire is formed by drawing a hollow glass fiber from a container in which molten alloy is entrained and solidified. Interference stresses extant between the glass coating and the alloy core of the wire are produced by systematically controlling thickness and mechanical elastic properties of the glass. The interference stress is tailored by selection of glass thickness and chemistry to optimize wire drawing process conditions, such as drawing temperature and strain rate. In addition, the interference stress is especially tailored to assure physical integrity of the glass-alloy composite wire product. Local property variations along the wire length are minimized, facilitating production of discrete wire segments especially suited for use in EAS applications.

Abstract: A glass-coated amorphous metallic microwire is encoded with multi-bit digital information. Encoding is achieved magnetically, optically or through a combination of magnetic and optical encoding processes. Magnetic encoding is carried out by modifying the constituent magnetic domain structure through selective relief of interfacial stress between the glass coating and the amorphous metallic alloy core. It is also achieved by selective surface crystallization of the amorphous metallic core in order to produce a controlled magnetic bias field. Optical encoding is associated with the glass coating. It is readily achieved by fluorescent element deposition, patterned removal of fluorescent element coating, Bragg grating, and thermally activated pattern deposition. The magnetic and optical multi-bit encoding approaches for glass-coated amorphous metallic microwire can be used individually or collectively in either a redundant or a complementary manner.

Abstract: Methods and apparatus for implementing high-bandwidth memory subsystems in a multiprocessor computing environment. Each component in the memory subsystem has a recalibration procedure. The computer provides a low-frequency clock signal with a period substantially equal to the duration between recalibration cycles of the components of the memory subsystem. Transitions in the low-frequency clock signal initiate a deterministically-determined delay. Lapse of the delay in turn triggers the recalibration of the components of the memory subsystem, ensuring synchronous recalibration. Synchronizing the recalibration procedures minimizes the unavailability of the memory subsystems, consequently reducing voting errors between CPUs.

Abstract: A class of active agents, and articles and compositions containing them and methods for treating human patients with them, which inhibit bone resorption of all types. This class of active agents comprises phosphodiester inhibiting compositions which inhibit any of interleukin 1 (IL1), interleukin 6 (IL6) and tumor necrosis factor alpha (TNF), which are cytokines that mediate bone resorption. Exemplary compositions in this class include: pentoxifylline; isobutylmethyl xanthine; ciprofloxacin; rolipram; terferol; and the quinolones generally. Each of these IL1/IL6/TNF inhibitors may be administered alone or in combination by a variety of delivery routes and dosage forms, and they may optionally be administered in conjunction with additional active agents including but not limited to metal chelators.