Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Disclosed is a dispensing head that includes a first spindle configured for movement in a vertical direction, a first nozzle operatively attached to the spindle, a heater device removably attachable to the dispensing head. The heater device includes a heat source and an opening configured to receive the first nozzle. The heat source is configured to heat the first nozzle above an ambient temperature. An assembly system is further disclosed, along with a method of heating a nozzle.

Abstract: Disclosed is a dispensing head that includes a first spindle configured for movement in a vertical direction, a first nozzle operatively attached to the spindle, a heater device removably attachable to the dispensing head. The heater device includes a heat source and an opening configured to receive the first nozzle. The heat source is configured to heat the first nozzle above an ambient temperature. An assembly system is further disclosed, along with a method of heating a nozzle.

Abstract: The invention provides methods of detecting a natriuretic protein, a troponin, and galectin-3 in samples from subjects in order to determine risk of developing new onset heart failure with preserved ejection fraction (HFpEF).

Abstract: A sports training aid for attaching a free end of a shaft of an article of athletic equipment to a resistance source, including at least one coupling member having two opposite ends. The first end is coupled to the free end of the shaft of the athletic equipment and the second end is coupled to the resistance source.

Abstract: Methods and systems for performing enterprise space management and for performing building restack operations are provided herein. A space management database system prepares and exports space management data for manual restacking by a user. The database system groups records by zone or by a commonality such as being located within a common divisible location, and exports the data in an editable format, e.g., as a spreadsheet. After a user edits the restack data to indicate a move within an organization's space under management, the data is imported back into the space management database, and then applied against one or more future planning periods to indicate a move of a cost center to or from a location.

Abstract: Systems and methods deliver a dynamic telephone directory to wireless handsets of emergency services personnel for responding to an incident. When an incident occurs, wireless handsets of emergency services personnel near the incident are identified. An incident-specific telephone directory is generated using information stored in a database of emergency response personnel including wireless handsets of emergency services personnel within an incident response area plus personnel outside the area with responsibilities for managing or assisting in the incident response. The incident-specific telephone directory is then delivered to wireless handsets of emergency services personnel. The database of emergency services personnel and the incident-specific telephone directory may be organized by name, roles and responsibilities, agency, geography, incident type, and response plan.

Abstract: Computer-simulated three-dimensional environments include automatable and/or constrainable camera control, for video gameplay, real estate and/or landscape demonstrations, or any other digitizable environment. In gameplay applications, the system can be customizably programmed to automatically adapt to the environment based on the player's location within the virtual environment, information about what the programmer believes is relevant (or wants to make relevant) in the scene being displayed, and other factors. Certain embodiments of the inventive apparatus and methods generally automatically incorporate and honor the “rules of cinematography,” but also preferably include other “action video game” principles that can override or trump those rules.

Abstract: Systems and methods deliver a dynamic telephone directory to wireless handsets of emergency services personnel for responding to an incident. When an incident occurs, wireless handsets of emergency services personnel near the incident are identified. An incident-specific telephone directory is generated using information stored in a database of emergency response personnel including wireless handsets of emergency services personnel within an incident response area plus personnel outside the area with responsibilities for managing or assisting in the incident response. The incident-specific telephone directory is then delivered to wireless handsets of emergency services personnel. The database of emergency services personnel and the incident-specific telephone directory may be organized by name, roles and responsibilities, agency, geography, incident type, and response plan.

Abstract: Embodiments of systems and methods provide deployable cellular telecommunication base stations capable of sending, receiving, and extending telephone calls in areas where commercial cellular communications are unavailable. The deployable base station can send and receive cellular telephone calls via cellular communication transceivers, and relay such calls to a distant teleport via a satellite communication link. The deployable base station includes routers for encoding voice calls in voice-over IP data format and for routing calls via the satellite communication link. The deployable base station may also include land mobile radio (LMR) communication interoperability circuits to enable LMR communications to be relayed to a distant teleport. At the teleport, received communications can be routed via a public switched telephone network to an intended receiver to enable telephone communications with the global commercial network from areas lacking commercial cellular communications.

Abstract: A Scalable Network-Attached Storage system, a Secure Scalable Network-Attached Storage system and a Peer-Based Storage Network all with high performance and scalability are described by this invention, which uses Dynamic Access Distribution to avoid scaling penalties.

Abstract: An optical transmission apparatus for transmission of optical signals at an optical wavelength of about 1550 nanometers. The optical transmission apparatus includes a single mode optical fiber link formed of optical fiber having substantially zero dispersion at an optical wavelength of about 1300 nanometers and a dispersion of about 17 picoseconds per nanometer-kilometer at an optical wavelength of about 1500 nanometers. Further, at least one dispersion compensating chirped optical fiber grating is coupled to the optical fiber link, the aggregate dispersion of the at least one dispersion compensating chirped optical fiber grating substantially compensating for the dispersion of the optical fiber link. Further, the at least one dispersion compensating chirped optical fiber grating is coupled at respective positions substantially symmetrically disposed about the longitudinal center of the optical fiber link.

Abstract: Method and apparatus for determining the alignment of a data track on a magnetic disc, for example a floppy disc and for determining the alignment of a read/write head in disc drive writing apparatus. In the method the radius of the circumferential center line of the track is determined by determining the radius of the peak value of the transverse envelope of the signal on the data track. The peak value is determined by computing the track average amplitude at a number of incremental positions transversely across the data track. The peak value and its radial position is then computed using a parabolic curve fitting technique.