Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-8 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Non-directional and diffuse reflecting photometric properties may be imbued to a metal sheet stock, particularly aluminum alloy sheet stock, by directly creating a textured surface on one or more surfaces of the sheet stock through mechanical texturing with at least one textured work roll in a cold roll reducing mill. A textured metal sheet surface thus produced is characterized by having over its entire surface randomly formed imbricated depressions transversely arranged, such that each depression has a substantially transverse width dimension relative to a longitudinal axis of the sheet and a longitudinal dimension greater than its width. The depressions formed are substantially equiaxial. Surface properties of both the textured work roll and the textured metal sheet may be controlled. The metal sheet stock are subjected to finishing steps such as chemical brightening and anodizing, or organic coating to provide lighting sheets with high total reflectance.

Abstract: Non-directional and diffuse reflecting photometric properties may be imbued to a metal sheet stock, particularly aluminum alloy sheet stock, by directly creating a textured surface on one or more surfaces of the sheet stock through mechanical texturing with at least one textured work roll in a cold roll reducing mill. A textured metal sheet surface thus produced is characterized by having over its entire surface randomly formed imbricated depressions transversely arranged, such that each depression has a substantially transverse width dimension relative to a longitudinal axis of the sheet and a longitudinal dimension greater than its width. The depressions formed are substantially equiaxial. Surface properties of both the textured work roll and the textured metal sheet may be controlled. The metal sheet stock are subjected to finishing steps such as chemical brightening and anodizing, or organic coating to provide lighting sheets with high total reflectance.