Abstract: A system and method for analyzing a plurality of datasets acquired from a plurality of data sources includes identifying at least one descriptor common to the datasets. The method also includes using the at least one descriptor to calculate intra-data-source signed matrices and generating a similarity matrix based on the intra-data-source signed matrices. The method further includes analyzing an alignment of the data-sources using the similarity matrix and at least one analysis metric and generating a report indicating at least a similarity of the data sources.