Patents by Inventor James Onuffer

James Onuffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF
    Publication number: 20230051989
    Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
    Type: Application
    Filed: September 14, 2022
    Publication date: February 16, 2023
    Inventors: Chia-Yung Wu, James Onuffer, Wendell A. Lim
  • Chimeric antigen receptor and methods of use thereof
    Patent number: 11478510
    Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: October 25, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Chia-Yung Wu, James Onuffer, Wendell A. Lim
  • CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF
    Publication number: 20210196757
    Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
    Type: Application
    Filed: December 8, 2020
    Publication date: July 1, 2021
    Inventors: Chia-Yung Wu, James Onuffer, Wendell A. Lim
  • Chimeric antigen receptor and methods of use thereof
    Patent number: 10888581
    Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: January 12, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Chia-Yung Wu, James Onuffer, Wendell A. Lim
  • CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF
    Publication number: 20200237824
    Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
    Type: Application
    Filed: March 19, 2020
    Publication date: July 30, 2020
    Inventors: Chia-Yung Wu, James Onuffer, Wendell A. Lim
  • Chimeric antigen receptor and methods of use thereof
    Patent number: 10632152
    Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: April 28, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Chia-Yung Wu, James Onuffer, Wendell A. Lim
  • Chimeric antigen receptor and methods of use thereof
    Patent number: 10105391
    Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: October 23, 2018
    Assignee: The Regents of the University of California
    Inventors: Chia-Yung Wu, James Onuffer, Wendell A. Lim
  • CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF
    Publication number: 20180085401
    Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
    Type: Application
    Filed: December 7, 2017
    Publication date: March 29, 2018
    Inventors: Chia-Yung Wu, James Onuffer, Wendell A. Lim
  • CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF
    Publication number: 20180042963
    Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
    Type: Application
    Filed: November 1, 2017
    Publication date: February 15, 2018
    Inventors: Chia-Yung Wu, James Onuffer, Wendell A. Lim
  • CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF
    Publication number: 20170340672
    Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
    Type: Application
    Filed: August 4, 2017
    Publication date: November 30, 2017
    Inventors: Chia-Yung Wu, James Onuffer, Wendell A. Lim
  • Chimeric antigen receptor and methods of use thereof
    Patent number: 9821012
    Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: November 21, 2017
    Assignee: The Regents of the University of California
    Inventors: Chia-Yung Wu, James Onuffer, Wendell A. Lim
  • CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF
    Publication number: 20170143765
    Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
    Type: Application
    Filed: January 30, 2017
    Publication date: May 25, 2017
    Inventors: Chia-Yung Wu, James Onuffer, Wendell A. Lim
  • Chimeric antigen receptor and methods of use thereof
    Patent number: 9587020
    Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: March 7, 2017
    Assignee: The Regents of the University of California
    Inventors: Chia-Yung Wu, James Onuffer, Wendell A. Lim
  • CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF
    Publication number: 20160185862
    Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
    Type: Application
    Filed: March 9, 2016
    Publication date: June 30, 2016
    Inventors: Chia-Yung Wu, James Onuffer, Wendell A. Lim
  • CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF
    Publication number: 20150368342
    Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
    Type: Application
    Filed: February 14, 2014
    Publication date: December 24, 2015
    Inventors: Chia-Yung WU, James ONUFFER, Wendell A. LIM
  • Substituted quinoline CCR5 receptor antagonists
    Patent number: 7220856
    Abstract: The present invention relates to CCR5 receptor antagonists of formulae (1a) or (1b): enantiomers, diastereomers, salts and solvates thereof wherein R1, R2, R3, R4, R5, and R7 are as defined herein. The invention further includes a method of CCR5-mediated disorders employing such compounds.
    Type: Grant
    Filed: June 26, 2003
    Date of Patent: May 22, 2007
    Assignee: Schering Aktiengesellschaft
    Inventors: Laura Dunning, Stefan Jaroch, Monica J. Kochanny, Wheeseong Lee, Xiongdong Lian, Meina Liang, Shou-Fu Lu, James Onuffer, Gary Phillips, Guo-Ping Wei, Bin Ye
  • Substituted quinoline CCR5 receptor antagonists
    Publication number: 20040072818
    Abstract: The present invention relates to CCR5 receptor antagonists of formulae (1a) or (1b): 1
    Type: Application
    Filed: June 26, 2003
    Publication date: April 15, 2004
    Applicant: Schering Aktiengesellschaft
    Inventors: Laura Dunning, Stefan Jaroch, Monica J. Kochanny, Wheeseong Lee, Xiongdong Lian, Meina Liang, Shou-Fu Lu, James Onuffer, Gary Phillips, Guo-Ping Wei, Bin Ye