Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to 5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile compounds (referred to herein as “TFM compounds”) which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc.

Abstract: Disclosed is a method of adjusting a motion profile of a shooting pot plunger for use in a molding system, the shooting pot plunger slidably movable within a shooting pot cavity, the method comprising: sensing a characteristic at a predetermined location in an injection circuit of the molding system; determining that the sensed characteristic is outside of a threshold range; adjusting the motion profile of the shooting pot plunger to account for determining that the sensed characteristic is outside of the threshold range; and storing the adjusted motion profile in a memory.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to 5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile compounds (referred to herein as “TFM compounds”) which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc.

Abstract: Disclosed herein, amongst other things, is a gate and a related method of forming the gate, having structure and steps of providing a base of a first base material, the base having a gate area, adding a layer of a second material to the base in the gate area by an additive manufacturing process to form a metallurgical bond, wherein the second material has a characteristic that differentiates the second material from the first base material and modifying an inner surface in the gate area comprised of the second material to define the gate.

Abstract: The present application describes injection molding machines and, more particularly, a removable nozzle tip and nozzle assembly for use with an injection molding machine and an engagement tool and methods for replacing a nozzle tip. In an aspect, an injection molding machine may include a nozzle. The nozzle may include a nozzle housing and a nozzle tip threadably attached to the nozzle housing. At least a portion of an exterior wall of the nozzle housing and at least a portion of an exterior wall of the nozzle tip may align to provide a cylindrical surface. The injection molding machine may further include a tubular heater enclosing at least a portion of the continuous cylindrical surface. The nozzle tip does not include a torque feature in any location that is downstream of the tubular heater and upstream of a mold gate of the nozzle.

Abstract: This disclosure relates to the field of zero-field paramagnetic resonance magnetometer (ZF-PRM). A sensitive ZF-PRM capable of measuring magnetic field in three orthogonal directions simultaneously and method of measuring magnetic field in three orthogonal directions is described. The ZF-PRM provides three independent output signals proportional to the three orthogonal vector components of the magnetic field using a single vapor cell, thus reducing complexity and cost of the magnetometer. Because all three magnetic components are measured at substantially the same location at the same time, the accuracy of data is greatly increased.

Abstract: Disclosed is a method of manufacturing a manifold for use in plastic injection molding, the method comprising additive manufacturing a melt distribution structure onto a manifold base plate, wherein the manifold base plate comprises a critical assembly feature.

Abstract: The disclosure describes a system that assigns an internet protocol (IP) address to each of one or more tenants, establishes an inbound connection with each of one or more tenants, and identifies each of one or more tenants based on the IP address and a destination address associated with the each of one or more tenants. The system further establishes an outbound connection with the each of one or more tenants, receives one or more commands and a message from each of one or more tenants, and determines an email address of at least one first tenant, of the one or more tenants, based at least in part on the one or more commands and the message. The system further updates one or more email addresses in one or more message headers with the domain of the at least one first tenant, and transmits the message to the at least one first tenant during an overlapping simple mail transport protocol (SMTP) session.

Abstract: The disclosure describes a system that assigns an internet protocol (IP) address to each of one or more tenants, establishes an inbound connection with each of one or more tenants, and identifies each of one or more tenants based on the IP address and a destination address associated with the each of one or more tenants. The system further establishes an outbound connection with the each of one or more tenants, receives one or more commands and a message from each of one or more tenants, and determines an email address of at least one first tenant, of the one or more tenants, based at least in part on the one or more commands and the message. The system further updates one or more email addresses in one or more message headers with the domain of the at least one first tenant, and transmits the message to the at least one first tenant during an overlapping simple mail transport protocol (SMTP) session.

Abstract: Disclosed herein, amongst other things, is a gate and a related method of forming the gate, having structure and steps of providing a base of a first base material, the base having a gate area, adding a layer of a second material to the base in the gate area by an additive manufacturing process to form a metallurgical bond, wherein the second material has a characteristic that differentiates the second material from the first base material and modifying an inner surface in the gate area comprised of the second material to define the gate.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to 5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile compounds (referred to herein as “TFM compounds”) which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc.

Abstract: The present invention relates to novel aminoindazolyl derivative compounds of Formula (I), the use of said compounds in treating diseases mediated by modulation of voltage-gated sodium channels in particular Nav1.7 AND to compositions containing said derivatives.

Abstract: Disclosed is a method of adjusting a motion profile of a shooting pot plunger for use in a molding system, the shooting pot plunger slidably movable within a shooting pot cavity, the method comprising: sensing a characteristic at a predetermined location in an injection circuit of the molding system; determining that the sensed characteristic is outside of a threshold range; adjusting the motion profile of the shooting pot plunger to account for determining that the sensed characteristic is outside of the threshold range; and storing the adjusted motion profile in a memory.

Abstract: Disclosed is a control system for and a method of filling a shooting pot cavity in a molding system, the method comprising: injecting resin from an injection unit to fill the shooting pot cavity; measuring a property of the resin at a predetermined location in the molding system; determining that the measured property is outside of a threshold range for the property, the threshold range being associated with the predetermined location; and selecting an operational parameter to adjust, the operational parameter associated with the measured property and the predetermined location.

Abstract: A system and method to measure a magnetic gradient field with an optically-pumped magnetometer is described. Atoms are spin polarized at two locations. Larmor frequencies are, induced and the spin frequency is detected. The frequencies are proportional to the total magnetic field at the locations of the atoms. The magnetic field gradient is extracted from the beat frequency of the two Larmor frequencies.

Abstract: A computer-implemented method for determining an amount of hydrocarbon fluid present in a rock of a hydrocarbon-producing reservoir is provided. The rock comprises organic matter and porous and permeable inorganic matter. The method comprises the steps of receiving data relating to chemical and kinetic properties of the organic matter, rock lithology data, rock thickness and reservoir temperature and pressure data, inputting the received data into a computer-implemented model, and operating the model. The model operates to a) simulate hydrocarbon fluid generation in the rock based on the input data and thereby determine an amount of generated hydrocarbon fluid, b) generate predicted data, and c) determine a total amount of hydrocarbon fluid present in the rock based on the predicted data.

Abstract: The present invention relates to novel aminoindazolyl derivative compounds of Formula (I), the use of said compounds in treating diseases mediated by modulation of voltage-gated sodium channels in particular Nav1.7 AND to compositions containing said derivatives.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to 5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile compounds (referred to herein as “TFM compounds”) which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc.

Abstract: Systems and methods for controlling the closing speed of valve gated nozzles are disclosed. In one embodiment, a hot runner have a valve gated nozzle including a valve stem movable between an open position and a closed position is provided. The valve stem is moved at a first speed for a first portion of valve stem closure and a second speed for a second end portion of the valve stem closure.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to 5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile compounds (referred to herein as “TFM compounds”) which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc.