Patents by Inventor James P. Allison

James P. Allison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LILRB4-BINDING ANTIBODY AND METHODS OF USE THEREOF
    Publication number: 20220144944
    Abstract: Provided herein are LILRB4-binding antibodies and methods of treating cancer by administering the LILRB4-binding antibodies alone or in combination with other therapies. Recombinant polypeptides comprising the CDRs of LILRB4-binding antibodies are also provided.
    Type: Application
    Filed: March 2, 2020
    Publication date: May 12, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Naveen SHARMA, James P. ALLISON
  • COMBINATION OF EZH2 INHIBITOR AND CHECKPOINT THERAPY FOR THE TREATMENT OF CANCER
    Publication number: 20210260051
    Abstract: Provided herein are methods of treating cancer comprising administering an EZH2 inhibitor which may be combined with an immune checkpoint inhibitor. Further provided herein are methods of depleting regulatory T cells (Tregs) in a subject comprising administering an EZH2 inhibitor to the subject. Also provided herein are pharmaceutical compositions comprising CPI-1205 and an immune checkpoint inhibitor.
    Type: Application
    Filed: June 14, 2019
    Publication date: August 26, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Padmanee SHARMA, James P. ALLISON, Sangeeta GOSWAMI
  • ANTIBODIES TO HUMAN B7X FOR TREATMENT OF METASTATIC CANCER
    Publication number: 20200392246
    Abstract: Methods are provided for treating metastatic cancer in patients having metastatic cancer or for preventing metastasis in cancer patients at risk for metastasis comprising administering to the patient an antibody to B7x, or an active antibody fragment that binds B7x, in an amount effective to treat or prevent metastasis.
    Type: Application
    Filed: August 27, 2020
    Publication date: December 17, 2020
    Inventors: Xingxing ZANG, James P. ALLISON
  • ANTIBODIES TO HUMAN B7X FOR TREATMENT OF METASTATIC CANCER
    Publication number: 20170029525
    Abstract: Methods are provided for treating metastatic cancer in patients having metastatic cancer or for preventing metastasis in cancer patients at risk for metastasis comprising administering to the patient an antibody to B7x, or an active antibody fragment that binds B7x, in an amount effective to treat or prevent metastasis.
    Type: Application
    Filed: August 31, 2016
    Publication date: February 2, 2017
    Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC., SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
    Inventors: Xingxing Zang, James P. Allison
  • Antibodies to human B7x for treatment of metastatic cancer
    Patent number: 9447186
    Abstract: Methods are provided for treating metastatic cancer in patients having metastatic cancer or for preventing metastasis in cancer patients at risk for metastasis comprising administering to the patient an antibody to B7x, or an active antibody fragment that binds B7x, in an amount effective to treat or prevent metastasis.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: September 20, 2016
    Assignees: Albert Einstein College of Medicine, Inc., Sloan-Kettering Institute for Cancer Research
    Inventors: Xingxing Zang, James P. Allison
  • ANTIBODIES TO HUMAN B7X FOR TREATMENT OF METASTATIC CANCER
    Publication number: 20140037551
    Abstract: Methods are provided for treating metastatic cancer in patients having metastatic cancer or for preventing metastasis in cancer patients at risk for metastasis comprising administering to the patient an antibody to B7x, or an active antibody fragment that binds B7x, in an amount effective to treat or prevent metastasis.
    Type: Application
    Filed: October 10, 2013
    Publication date: February 6, 2014
    Applicants: Sloan-Kettering Institute For Cancer Research, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Xingxing Zang, James P. Allison
  • Diagnosis of prostate cancer with SPAS-1 cancer antigen
    Patent number: 7704701
    Abstract: Compounds and methods for inducing protective immunity against cancer are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more SPAS-1 proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and pharmaceutical compositions for immunization against cancer, or can be used for the diagnosis of cancer and the monitoring of cancer progression.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: April 27, 2010
    Assignee: The Regents of the University of California
    Inventors: James P. Allison, Marcella Fasso, Nilabh Shastri
  • Stimulation of T Cells Against Self-Antigens Using CTLA-4 Blocking Agents
    Publication number: 20090269353
    Abstract: Stimulation of T cells to respond to self antigens is achieved through a blockade of CTLA-4 signaling. CTLA-4 blocking agents are combined with antigen preparations, either alone or with additional immune response stimulating agents, in costimulation strategies to break immune tolerance and stimulate an enhanced T-cell response against self antigens. This enhanced response is useful for the treatment of non-immunogenic and poorly-immunogenic tumors, as well as other medical conditions requiring selective tissue ablation.
    Type: Application
    Filed: April 9, 2009
    Publication date: October 29, 2009
    Applicant: The Regents of the University of California
    Inventors: James P. ALLISON, Andrea Van Elsas, Arthur A. Hurwitz
  • Compositions and methods for modulating lymphocyte activity
    Publication number: 20040175380
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
    Type: Application
    Filed: June 20, 2003
    Publication date: September 9, 2004
    Inventors: James P. Allison, Kenneth P. Murphy, Norihiko Watanabe, Theresa L. Murphy, Jianfei Yang, Xingxing Zang
  • SPAS-1 cancer antigen
    Publication number: 20020150588
    Abstract: Compounds and methods for inducing protective immunity against cancer are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more SPAS-1 proteins and DNA molecules encoding such polypeptides.
    Type: Application
    Filed: September 13, 2001
    Publication date: October 17, 2002
    Inventors: James P. Allison, Marcella Fasso, Nilabh Shastri