Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Soiled foodware is cleaned in a batch-type machine in which the foodware is subjected to a washing cycle and a chemical sanitizing rinsing cycle. A controlled flow of fresh preheated rinse water is supplied to an accumulation tank during the wash cycle while a drying agent is optionally added to the water in the tank. Thereafter, the rinse cycle is initiated by pumping the accumulated fresh water into a rinse line at a predetermined pressure to provide uniform flow in the rinse line. A liquid chemical sanitizing agent is then introduced directly into the uniform flow of water in the rinse line. This sequence of operations provides a desired uniform water pressure, independent of water supply pressure, for effective rinsing action and accurate metering of sanitizing agent into the uniform flow of water in the rinse line.

Abstract: An improved dishwashing system includes operating methods and apparatus for water and energy conservation and elimination of spot-reducing chemicals in the rinse water. Return water from the rinse cycle is stored in insulated tanks and rinse water flowing to the dishwasher absorbs heat from the return water to thereby conserve the heat energy of the return water while simultaneously cooling the return water to a selected temperature in preparing a feed solution for membrane separation. A controlled quantity of make-up water is added to the feed solution which is raised to a selected pressure to provide for reverse osmosis purification and deionization. The reverse osmosis effluent is accumulated and, when needed, boosted in pressure to a desired operational dishwasher pressure, and heated to sanitizing level so as to achieve desired bacterial count levels during rinse cycles. Rinsing with the purified and deionized water results in film-free and spot-free dishes after drying.