Abstract: Disclosed is a compound having the Formula (I): X-[NH—CHR1—C(O)—NH—CHR2—C(O)]x—Y (I) or a pharmaceutically acceptable salt or tautomer thereof, wherein R1 is H or the side chain of a neutral amino acid; R2 is the side chain of a basic amino acid R3; x is inclusive; X is H or a residue of a therapeutic agent; Y is OH, or a residue of a therapeutic agent; R3 is: [Formula should be inserted here]; R5 is a residue of a therapeutic agent; and provided that when R2 is R3, X is H and Y is —OH. Also disclosed is a method of treating an ocular disorder, comprising: (a) intravitreal administration to an eye of a subject in need thereof with an effective amount of a therapeutic nanoparticle composition, the therapeutic nanoparticle composition comprising (i) at least one population of nanostructures and (ii) at least one peptide attached to the at least one population of nanostructures. The nanostructures may be exposed to light in the eye thereby electrostimulating the eye and treating the ocular disorder.

Abstract: Disclosed is a method of treating an ocular disorder, comprising contacting the eye of a subject in need thereof with an effective amount of a therapeutic nanoparticle composition, the therapeutic nanoparticle composition comprising (i) at least one population of nanostructures, (ii) a peptide attached to the at least at least one population of nanostructures, (iii) a therapeutic agent useful for the treatment of the ocular disorder attached to the at least one population of nanostructures or to the peptide; and (iv) optionally, a linkage between the at least one population of nanostructures or the peptide and the therapeutic agent.

Abstract: Compositions and methods for treating a contact lens very effectively and conveniently provide enhanced contact lens wearability by reducing the actual or perceived ocular sensitivity which results from exposing a contact lens to non-oxidative antimicrobial components. The present system takes advantage of inactivating or deactivating a non-oxidative antimicrobial component located on or in a contact lens to reduce the ocular sensitivity caused by placing the lens in the eye.