Patents by Inventor James P. Karwowski

James P. Karwowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5863773
    Abstract: Disclosed are novel antifungal agents having the formula: ##STR1## as well as a pharmaceutically acceptable salt, ester of prodrug thereof, whereinR is: ##STR2## --C(O)--R.sub.1 wherein R.sub.1 is alkyl, alkenyl, aryl, arylalkenyl, aryl-aryl-, arylalkoxy-aryl-, aryl-aryl-aryl-, arylkoxy-aryl-aryl-, or ##STR3## wherein R.sub.2 is alkylamino, dialkylamino, (heterocyclic)alkyl, aryl, or arylalkyl; andX is O, NH, or NR.sub.3 wherein R.sub.3 is alkyl or aryl. Also disclosed are pharmaceutical compositions comprising a compound of the invention in combination with a pharmaceutically acceptable carrier; and a process for preparing the compounds of the invention.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: January 26, 1999
    Assignee: Abbott Laboratories
    Inventors: Geewananda P. Gunawardana, David Frost, Marianna Jackson, James P. Karwowski, Ronald R. Rasmussen
  • Patent number: 5589485
    Abstract: Novel antifungal and antitumor agents having the formula ##STR1## as well as pharmaceutically acceptable salts, esters, amides and pro-drugs thereof, wherein R is selected from the group consisting of ##STR2## Also disclosed are pharmaceutical compositions comprising such compounds, and methods of treatment and processes of manufacture relating thereto.
    Type: Grant
    Filed: April 26, 1995
    Date of Patent: December 31, 1996
    Assignee: Abbott Laboratories
    Inventors: Jill E. Hochlowski, Marianna Jackson, Sunil K. Kadam, James P. Karwowski, James B. McAlpine
  • Patent number: 5484799
    Abstract: Novel antifungal and antitumor agents having the formula ##STR1## as well as pharmaceutically acceptable salts, esters, amides and pro-drugs thereof, wherein R is selected from the group consisting of ##STR2## Also disclosed are pharmaceutical compositions comprising such compounds, and methods of treatment and processes of manufacture relating thereto.
    Type: Grant
    Filed: December 9, 1993
    Date of Patent: January 16, 1996
    Assignee: Abbott Laboratories
    Inventors: Jill E. Hochlowski, Marianna Jackson, Sunil K. Kadam, James P. Karwowski, James B. McAlpine
  • Patent number: 5192748
    Abstract: New antibiotics, unphenelfamycin and phenelfamycins A-D, are produced by microorganisms belonging to the genus Streptomyces. The antibiotics have antibacterial activity against gram-positive and gram-negative anaerobic organisms and are effective in improving the feed efficiency and growth rate of livestock, including poultry.
    Type: Grant
    Filed: August 5, 1991
    Date of Patent: March 9, 1993
    Assignee: Abbott Laboratories
    Inventors: Jill E. Hochlowski, Mark H. Buytendorp, Randal H. Chen, James B. McAlpine, Robert J. Theriault, Marianna Jackson, James P. Karwowski
  • Patent number: 5171740
    Abstract: A mixture of new coumamidine compounds are produced by a microorganism, belonging to the genus Saccharopolyspora. The compounds have antibiotic activity against a broad spectrum of bacteria.
    Type: Grant
    Filed: May 28, 1991
    Date of Patent: December 15, 1992
    Assignee: Abbott Laboratories
    Inventors: James B. McAlpine, Robert J. Theriault, James P. Karwowski, Marianna Jackson, Randal H. Chen