Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed.

Abstract: The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

Abstract: A thermal processing and consolidation system includes an upper assembly, a lower assembly, and an air impingement device. At least one of the upper assembly or the lower assembly is a chamber assembly. The upper assembly and the lower assembly are movable relative to one another between an opened position where the upper assembly and the lower assembly are detached from one another, and a closed position where the upper assembly and the lower assembly are coupled to one another and form an enclosed plenum for receiving a tool. The air impingement device is arranged at least partially in the plenum, and configured to direct forced flows of air at the tool when the tool is received in the plenum.

Abstract: A system to re-configure an input material into an output material includes an input material feeder reconfigurable to accept and feed an input material, an output material spooler, the input material feeder re-configurable relative to the material cutter to cut the input material at a re-configurable cut angle to produce a first intermediate cut section of material, a positioning and alignment system to position and align a leading edge of the first intermediate cut section of material with a trailing edge of a second intermediate cut section of material, a welder having a configurable position to weld the first intermediate cut section of material to the second intermediate cut section of material, and a control system comprising logic to set at least intensity of the welder, a contact pressure of the welder, temperature of the weld-table surface, and a tension applied by the output material spooler.

Abstract: A system to re-configure an input material into an output material includes an input material feeder reconfigurable to accept and feed an input material, an output material spooler, the input material feeder re-configurable relative to the material cutter to cut the input material at a re-configurable cut angle to produce a first intermediate cut section of material, a positioning and alignment system to position and align a leading edge of the first intermediate cut section of material with a trailing edge of a second intermediate cut section of material, a welder having a configurable position to weld the first intermediate cut section of material to the second intermediate cut section of material, and a control system comprising logic to set at least intensity of the welder, a contact pressure of the welder, temperature of the weld-table surface, and a tension applied by the output material spooler.

Abstract: A thermal processing and consolidation system includes an upper assembly, a lower assembly, and an air impingement device. At least one of the upper assembly or the lower assembly is a chamber assembly. The upper assembly and the lower assembly are movable relative to one another between an opened position where the upper assembly and the lower assembly are detached from one another, and a closed position where the upper assembly and the lower assembly are coupled to one another and form an enclosed plenum for receiving a tool. The air impingement device is arranged at least partially in the plenum, and configured to direct forced flows of air at the tool when the tool is received in the plenum.

Abstract: A fully automated method and apparatus is disclosed to laminate various structural articles with multiple layers of a resin impregnated fiber tape. The fiber tape is deposited with a tape laying member moving alternately in different travel directions. The tape laying member removes all backing layers from the tape being employed, then deposits the unbacked tape on the surface of the structural article and finally severs the end of the tape being deposited. An automated cut and restart procedure is employed in the present apparatus to increase throughput.

Abstract: A fully automated method and apparatus is disclosed to laminate various structural articles with a layer of resin impregnated fiber tape. The tape laying member removes a releasable backing layer from the tape being employed, then deposits the unbacked tape on the surface of the structural article, and finally severs the end of the tape being deposited. An automated cut and restart procedure is employed in the present tape laying member to increase tape throughput.

Abstract: First and second pant legs are removably attached to a pair of shorts to form a pair of long pants. A pouch is attached to an interior surface of the first pant leg. The pouch has a mouth that is accessible through an opening in the first pant leg. The pouch is dimensioned and positioned to receive the first and second pant legs after they have been removed from the shorts and folded up.

Abstract: A method of making an aluminum foil product from an aluminum-silicon-iron aluminum alloy comprises casting the alloy into a slab, preferably by twin roll casting, cold rolling the alloy to an intermediate gauge and reroll annealing the intermediate gauge material. The reroll annealed material is then cold rolled to a final foil gauge followed by a final recrystallizing annealing. The aluminum alloy has a controlled amount of silicon and iron such that the silicon is equal to or greater than the iron amount and the reroll anneal temperature is 800.degree. F. (427.degree. C.) or less. The combination of the controlled amounts of silicon and iron and the lower reroll anneal temperature results in an improved foil product in terms of finer grain size and higher elongation which is also less costly to produce.

Abstract: A maintenance system for an ink jet printer of the type having a full width array printhead has a movable carriage with a droplet sensor and a nozzle recovery device. As the carriage moves along the length of the printhead, each nozzle checked, one at a time, by the droplet sensor for the presence or absence of an ejected droplet and if the droplet has the correct directionality. Any problem nozzle is identified during a single traversal of the carriage across the printhead, and during a second traversal, the identified problem nozzles have a recovery operation performed on them such as being cleaned to remove any dried ink or other contaminating particles or being primed in the case of a clogged nozzle. The problem nozzles which have had a recovery operation performed on them and checked again by the droplet sensor is required for the entire array of nozzles, and ink is conserved since only predetermined nozzles are printed.

Abstract: An optical element uniformly distributes radiant energy on a target surface, such as for discharging an area of a photoreceptor in a xerographic printer, or for applying infrared energy to dry an ink-jet image. A cylinder lens collimates light beams from a light source and directs the collimated light beams to a preselected area on the target surface. First and second refractive portions, each attached to and extending parallel to the cylinder lens, totally internally reflect light beams from the light source and direct the light beams reflected therein to the target surface.

Abstract: An infrared densitometer which measures the diffuse component of reflectivity as marking particles are progressively deposited on a moving photoconductive belt. Collimated light rays are projected onto a test patch including the marking particles. The light rays reflected from the test patch are collected and directed onto a photodiode array. The photodiode array generates electrical signals proportional to the total flux and a diffuse component of the total flux of the reflected light rays. Circuitry compares the electrical signals and determines the difference to generate an electrical signal proportional to the specular component of the total flux of the reflected light rays. Additional circuitry adds the electrical signals proportional to the total flux and the diffuse component of the total flux of the reflected light rays and compares the result of the summed signal to the specular component to provide a total diffuse signal for controlling developed mass.

Abstract: An aluminum alloy composition for sheet product consists essentially of 0.3 to 1.1 wt. % silicon, 0.4 to 1.0 wt. % iron, 0.009 to 0.25 wt. % copper and optionally, minor amounts of manganese, magnesium, chromium, zinc, titanium and other incidental impurities with the balance aluminum. In making aluminum sheet from this composition, the aluminum alloy is continuously cast into an intermediate gauge sheet product and directly cold rolled without an intermediate thermal treatment to final gauge. Optionally, the final gauge sheet product can be subjected to a known temper practice. Using the iron, silicon and copper-containing aluminum alloy composition, a sheet product is produced which has acceptable mechanical properties for use as general purpose aluminum sheet, semi-rigid aluminum container stock, consumer wrap container cutter bars and the like.

Abstract: An apparatus and method for reliably monitoring the position of a radiant energy beam, for example, a scanning laser beam such as that produced by a raster output scanning system to expose a photoresponsive member, where the beam traverses the surface of a photoreceptive member at a high rate of speed. The apparatus, which includes a lateral-effect photodiode, is also capable of signaling when the radiant energy beam traverses a specific location. The apparatus may also be used to determine the relative intensity of the radiant energy beam, thereby significantly reducing the space and expense necessary to monitor the radiant energy beam by combining multiple sensing operation in a single apparatus.

Abstract: An apparatus for positional tracking a moving photoconductive belt and adjusting an imager in an electrophotographic printing machine to correct for alignment errors when forming a composite image. Registration errors are sensed by developing an appropriate set of target marks, detecting the target marks, and controlling the position of the imager.

Abstract: An apparatus and method for reliably monitoring the position of a radiant energy beam, for example, a scanning laser beam such as that produced by a raster output scanning system to expose a photoresponsive member, where the beam traverses the surface of a photoreceptive member at a high rate of speed. The apparatus, which includes a lateral-effect photodiode, is also capable of signaling when the radiant energy beam traverses a specific location. The apparatus may also be used to determine the relative intensity of the radiant energy beam, thereby significantly reducing the space and expense necessary to monitor the radiant energy beam by combining multiple sensing operation in a single apparatus.

Abstract: An apparatus and method of adjusting an imager in an electrophotographic printing machine to correct for registration errors when forming a composite image. Registration errors are sensed by forming one or more target lines on the photoreceptor surface, detecting the center of the lines and controlling the operation of the imager in response thereto. In one embodiment, four LED print bars form a composite color image in a single pass. A photosensor is placed beneath the print bars; a narrow target line is formed on the belt surface a few scan lines before the start of an exposure frame. The center of the line is detected by circuitry connected to the sensor output which produces a signal corresponding to detection of the center of the target line. This output signal is generated for each of the three downstream print bars and a signal is applied to each print bar to start the image exposure sequence in registration with first image exposure.

Abstract: A Raster Output Scanner (ROS) color printer is formed by providing several ROS imagers adjacent image exposure locations of a photoreceptor belt. Each ROS imager forms a separate color image in response to video input signals with each color image superimposed in registration over the previously formed images. Registration in the process direction is enabled by a quad cell photosensor whose output is continually compared to determine whether process registration deviations from a previously established position are necessary. Correction signals are generated in an iterative fashion until a preselected process registration position is re-established. The quad cell detector is also used for a second function; to produce the start and end of scan signals which enable image registration in the cross-process direction.