Patents by Inventor James P. Murphy

James P. Murphy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11733216
    Abstract: Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column. A method for configuring a chromatography system with independent control of system pressure and mass flow rate of a compressible mobile phase includes determining a type of chromatography separation column to be used in the chromatography system, matching a thermally modulated variable restrictor to the type of chromatography separation column for use together during operation of the chromatography system, and bundling the chromatography column with its matching thermally modulated variable restrictor for distribution as a single package.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: August 22, 2023
    Assignee: Waters Technologies Corporation
    Inventors: Michael O. Fogwill, Joseph D. Michienzi, Geoff Gerhardt, James P. Murphy
  • Patent number: 11092597
    Abstract: The present disclosure relates devices and methods for analyzing intact antibodies, antibody subunits, antibody drug conjugate subunits, antibody drug conjugates, and intact proteins in a biological mixture.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: August 17, 2021
    Assignee: WATERS TECHNOLIGIES CORPORATION
    Inventors: Gregory T. Roman, James P. Murphy
  • Patent number: 10953346
    Abstract: Solvent containers and solvent container trays for chromatography systems are described for providing control over solvent supply and waste collection. Designated solvent containers and exclusively designated solvent containers provide solvents for use by chromatography systems. Control over solvent supply is achieved by requiring matched container shape and container receiving position shape within the tray, and additionally or alternatively, through solvent container coding readable by the solvent tray and chromatography system which provide information about the solvent container to the chromatography system.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: March 23, 2021
    Assignee: Waters Technologies Corporation
    Inventors: Xiangjin Song, James P. Murphy, Keith Fadgen, Wade P. Leveille, Joseph D. Michienzi, Jonathan L. Belanger, Moon Chul Jung, Abhijit Tarafder
  • Patent number: 10877006
    Abstract: Burner assemblies of flame-based detectors are configured to deliver decompressed mobile phase of supercritical fluid chromatography systems to the flame of a flame-based detector while providing for improved optimization of analyte response as well as enhanced flame stability during operation.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: December 29, 2020
    Assignee: Waters Technologies Corporation
    Inventors: Michael O. Fogwill, Joseph D. Michienzi, James P. Murphy
  • Patent number: 10830742
    Abstract: The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol. Upon exiting a chromatographic column, the mobile phase containing the polar modifier is flowed through an oxidizer that contains a catalyst to oxidize at least a portion of the polar modifier to a species that does not interfere with the function of the flame-based detector. The oxidizer allows for flame-based detection, such as flame ionization detection, in applications in which a polar modifier with a reduced form of carbon is used.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: November 10, 2020
    Assignee: Waters Technologies Corporation
    Inventors: Michael O. Fogwill, Joseph D. Michienzi, James P. Murphy
  • Publication number: 20200333301
    Abstract: Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column. A method for configuring a chromatography system with independent control of system pressure and mass flow rate of a compressible mobile phase includes determining a type of chromatography separation column to be used in the chromatography system, matching a thermally modulated variable restrictor to the type of chromatography separation column for use together during operation of the chromatography system, and bundling the chromatography column with its matching thermally modulated variable restrictor for distribution as a single package.
    Type: Application
    Filed: June 30, 2020
    Publication date: October 22, 2020
    Inventors: Michael O. Fogwill, Joseph D. Michienzi, Geoff Gerhardt, James P. Murphy
  • Publication number: 20200064313
    Abstract: Described are stator arrays for multi-valve systems used in different chromatographic applications. Also described is a mounting assembly for a multi-valve system that includes the stator array. Each stator array has a stator body having a first stator surface and a second stator surface. Each stator surface has a plurality of stator ports and is configured to engage a rotor surface of a rotary valve actuator. A fluid channel inside the stator body couples one of the stator ports of the first stator surface to one of the stator ports of the second stator surface. The fluid channel may be a microfluidic channel. A solid-state diffusion bonding process in which two or more parallel layers of material are joined together may be used to fabricate the stator body. Complex fluid channel networks may be formed using many fluid channels formed in multiple layers within the stator body.
    Type: Application
    Filed: August 20, 2019
    Publication date: February 27, 2020
    Inventors: Sylvain Gilles Cormier, Charles H. Phoebe, Jr., Jason F. Hill, James P. Murphy, III
  • Publication number: 20190170710
    Abstract: The present disclosure relates to burner assemblies of flame-based detectors. These burner assemblies are configured to deliver decompressed mobile phase of supercritical fluid chromatography systems to the flame of a flame-based detector while providing for improved optimization of analyte response as well as enhanced flame stability during operation.
    Type: Application
    Filed: January 8, 2019
    Publication date: June 6, 2019
    Applicant: Waters Technologies Corporation
    Inventors: Michael O. Fogwill, Joseph D. Michienzi, James P. Murphy
  • Patent number: 10307511
    Abstract: The present invention generally relates to bioactive composites of polymer and glass and, more particularly, to bioactive implants. The present invention also relates to methods of manufacturing bioactive composites. The bioactive composite finds utility in a variety of load-bearing clinical applications including spine, orthopaedic and dental procedures.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: June 4, 2019
    Assignee: Orthovita, Inc.
    Inventors: Theodore D. Clineff, Marissa M. Conrad, Matthew B. Havener, James P. Murphy, Zachary S. Szczerbinski
  • Publication number: 20190125931
    Abstract: Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.
    Type: Application
    Filed: December 20, 2018
    Publication date: May 2, 2019
    Inventors: James P. Murphy, Erik M. Erbe, Charanpreet S. Bagga, Marissa M. Conrad
  • Publication number: 20190111376
    Abstract: The present disclosure relates to methodologies, systems, apparatus, kits, and microfluidic separation devices based on separation columns and restrictors that are matched and bundled together for distribution as a unit, where the mobile phase flow rate and post-column pressure are specified based on this combination of matched separation column and restrictor.
    Type: Application
    Filed: October 11, 2018
    Publication date: April 18, 2019
    Applicant: Waters Technologies Corporation
    Inventors: Michael O. Fogwill, James P. Murphy, Geoff C. Gerhardt
  • Publication number: 20190086373
    Abstract: The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol. Upon exiting a chromatographic column, the mobile phase containing the polar modifier is flowed through an oxidizer that contains a catalyst to oxidize at least a portion of the polar modifier to a species that does not interfere with the function of the flame-based detector. The oxidizer allows for flame-based detection, such as flame ionization detection, in applications in which a polar modifier with a reduced form of carbon is used.
    Type: Application
    Filed: November 21, 2018
    Publication date: March 21, 2019
    Applicant: Waters Technologies Corporation
    Inventors: Michael O. Fogwill, Joseph D. Michienzi, James P. Murphy
  • Patent number: 10195308
    Abstract: Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: February 5, 2019
    Assignee: Orthovita, Inc.
    Inventors: James P. Murphy, Erik M. Erbe, Charanpreet S. Bagga, Marissa M. Conrad
  • Patent number: 10191020
    Abstract: Burner assemblies are configured to deliver decompressed mobile phase of supercritical fluid chromatography systems to the flame of a flame-based detector while providing for improved optimization of analyte response as well as enhanced flame stability during operation.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: January 29, 2019
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Michael O. Fogwill, Joseph D. Michienzi, James P. Murphy
  • Patent number: 10151733
    Abstract: The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol. Upon exiting a chromatographic column, the mobile phase containing the polar modifier is flowed through an oxidizer that contains a catalyst to oxidize at least a portion of the polar modifier to a species that does not interfere with the function of the flame-based detector. The oxidizer allows for flame-based detection, such as flame ionization detection, in applications in which a polar modifier with a reduced form of carbon is used.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: December 11, 2018
    Assignee: Waters Technologies Corporation
    Inventors: Michael O. Fogwill, Joseph D. Michienzi, James P. Murphy
  • Patent number: 10071374
    Abstract: A microfluidic device, for use in separation systems, includes a substrate having a fluidic channel. One or more heaters made of a thick film material are integrated with the substrate and in thermal communication with the fluidic channel of the substrate. The one or more heaters produce a thermal gradient within the fluidic channel in response to a current flowing through the one or more heaters. A plurality of electrically conductive taps can be in electrically conductive contact with the one or more heaters. The plurality of electrically conductive taps provides an electrically conductive path to the one or more heaters by which an electrical supply can produce the current flowing through the one or more heaters. Alternatively, the thick film material can be ferromagnetic, and the electrical supply can use induction to cause the current to flow through the one or more heaters.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: September 11, 2018
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Joseph D. Michienzi, James P. Murphy, Michael O. Fogwill, Keith Fadgen, Geoff Gerhardt, Gary W. Bertone
  • Publication number: 20180246087
    Abstract: The present disclosure relates devices and methods for analyzing intact antibodies, antibody subunits, antibody drug conjugate subunits, antibody drug conjugates, and intact proteins in a biological mixture.
    Type: Application
    Filed: February 27, 2018
    Publication date: August 30, 2018
    Inventors: Gregory T. Roman, James P. Murphy
  • Publication number: 20180207549
    Abstract: Solvent containers and solvent container trays for chromatography systems are described for providing control over solvent supply and waste collection. Designated solvent containers and exclusively designated solvent containers provide solvents for use by chromatography systems. Control over solvent supply is achieved by requiring matched container shape and container receiving position shape within the tray, and additionally or alternatively, through solvent container coding readable by the solvent tray and chromatography system which provide information about the solvent container to the chromatography system.
    Type: Application
    Filed: January 17, 2018
    Publication date: July 26, 2018
    Inventors: Xiangjin Song, James P. Murphy, Keith Fadgen, Wade P. Leveille, Joseph D. Michienzi, Jonathan L. Belanger, Moon Chul Jung, Abhijit Tarafder
  • Patent number: 10024826
    Abstract: An apparatus for use in a chromatography system includes a microfluidic substrate having a fluidic channel configured as an analytical chromatographic column and a fluidic port on one side of the microfluidic substrate. The fluidic port opens at a head end of the analytical chromatographic column. A dried blood spot (DBS) collection device holds one or more dried biological samples. The DBS collection device is directly coupled to the microfluidic substrate whereby one of the biological samples is placed into fluidic communication with the fluidic channel of the microfluidic substrate and an extraction of that biological sample flows toward the head end of the analytical chromatographic column. A diluent source fluidically coupled to the fluidic port supplies a solvent to the head end of the analytical column to dilute the extracted biological sample before the biological sample flows into the analytical chromatographic column.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: July 17, 2018
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: James P. Murphy, Michael J. Tomany, Joseph D. Michienzi, Paul Rainville, Robert S. Plumb, Geoff C. Gerhardt, Moon Chul Jung
  • Patent number: 10006890
    Abstract: A chromatography system includes a separation column that separates a sample carried by a compressible mobile phase flow into analytes and a splitter in fluidic communication with the separation column to receive and divide the compressible mobile phase flow into first and second mobile phase streams in accordance with a split ratio. A thermally modulated variable restrictor is coupled between the splitter and a detector. The restrictor receives the first mobile phase stream from the splitter and has a temperature element in thermal communication with the first mobile phase stream to exchange heat therewith. A controller, in communication with the restrictor, dynamically adjusts a temperature setting of the temperature element of the restrictor to adjust the heat exchange between the thermally modulated variable restrictor and the first mobile phase stream in order to keep the split ratio constant throughout a chromatographic run.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: June 26, 2018
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Michael O. Fogwill, Joseph D. Michienzi, James P. Murphy