Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A device and system for purifying a fluid is provided. The system includes a tank having an interior space and a media container disposed within the interior space. A valve is provided that cooperates with an element within the interior, the valve being movable between an open and a closed position. The valve being biased to the open position when the element is not positioned within the interior space, wherein the interior space is fluidly coupled to the atmosphere in the open position. The valve further being configured to move to a closed position when the element is positioned within the interior space.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: This invention relates to the preparation of N-(phosphonomethyl)glycine (“glyphosate”) from N-(phosphonomethyl)iminodiacetic acid (“PMIDA”), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content.

Abstract: A device and system for purifying a fluid is provided. The system includes a tank having an interior space and a media container disposed within the interior space. A valve is provided that cooperates with an element within the interior, the valve being movable between an open and a closed position. The valve being biased to the open position when the element is not positioned within the interior space, wherein the interior space is fluidly coupled to the atmosphere in the open position. The valve further being configured to move to a closed position when the element is positioned within the interior space.

Abstract: Provided are techniques for exploiting object tags in order to produce a work order across several backup engines for a backup job. A selection of tags for an object is received. A work order for the object is created using the tags. The work order is stored with a virtual server that stores the object, wherein a data mover of a backup engine retrieves the work order from the virtual server to back up the object.

Abstract: A banking activity feed is generated for a client device. Processing is performed in connection with a plurality of accounts of an account holder. Based on the processing, activity items are generated comprising information regarding activity occurring in connection with the plurality of accounts. An activity feed is generated that comprises a list of the activity items from the plurality of accounts. The activity feed is displayed to a user via the client device.

Abstract: Provided are a computer program product, system, and method for hypervisor agnostic interchangeable backup recovery and file level recovery from virtual disks. Data is stored for a first virtual disk that represents data in a first format and metadata for the first virtual disk in a common data format in a storage having a fixed block length. A virtual disk file represents data in a second format that allows variable size blocks. Multiple instances of the fixed block length of blocks of data for the second virtual disk indicated in the virtual disk file are read. Each instance of the read fixed block length of blocks is written to the storage in the common data format with metadata describing the format of the blocks in the second virtual disk, and can be restored to a third virtual disk in the first or second format.

Abstract: For accessing files from block-level backups of a virtual disk, a system, method, computer program product and apparatus are disclosed. The system includes an apparatus with a changed block module that determines changed blocks between a previous and a current block-level backup of a virtual disk. A mapping module maps logical clusters of the virtual disk to the changed blocks and identifies files corresponding to the logical clusters. A changed file module designates files corresponding to the logical clusters as changed files, unless current attributes of files for the current backup match attributes of the files in a backup file index corresponding to the previous backup. The changed file module stores the current attributes and extents for changed files within blocks of a backup storage device for updating in the backup file index. The method and computer program product perform these functions and may use the system and the apparatus.

Abstract: In an approach to maintain data integrity in a computer data storage system, a clone management table is generated for a clone file tree that includes a relationship between at least one parent file and a clone file. The parent file is restored by: (i) determining that the parent-child relationship exists between the parent file and the clone file based on an entry in the clone management table, (ii) restoring data blocks in the parent file to the file system based on an analysis of an entry in the clone management table for the parent file and an identification of data blocks included in the clone file, and (iii) generating a new instance of the parent file based on the data blocks included in the file system and the entry in the clone management table for the clone file tree.

Abstract: Provided are techniques for providing and managing data protection by using incremental forever for storage to cloud object stores. An incremental offload is performed by using one or more extents to identify blocks of data for a version of a virtual machine in operational recovery storage to be offloaded to a cloud object store, wherein each of the one or more extents identifies locations of the blocks of data. The blocks of data are converted to objects in an incremental forever data format. The objects are offloaded to the cloud object store. The details of the offloading of the objects are stored in a local database in the operational recovery storage. The local database is copied from the operational recovery storage to the cloud object store as a database copy.

Abstract: Provided are techniques for providing and managing data protection by using incremental forever for storage to cloud object stores. An incremental offload is performed by using one or more extents to identify blocks of data for a version of a virtual machine in operational recovery storage to be offloaded to a cloud object store, wherein each of the one or more extents identifies locations of the blocks of data. The blocks of data are converted to objects in an incremental forever data format. The objects are offloaded to the cloud object store. The details of the offloading of the objects are stored in a local database in the operational recovery storage. The local database is copied from the operational recovery storage to the cloud object store as a database copy.

Abstract: Provided are a computer program product, system, and method for hypervisor agnostic interchangeable backup recovery and file level recovery from virtual disks. Data is stored for a first virtual disk that represents data in a first format and metadata for the first virtual disk in a common data format in a storage having a fixed block length. A virtual disk file represents data in a second format that allows variable size blocks. Multiple instances of the fixed block length of blocks of data for the second virtual disk indicated in the virtual disk file are read. Each instance of the read fixed block length of blocks is written to the storage in the common data format with metadata describing the format of the blocks in the second virtual disk, and can be restored to a third virtual disk in the first or second format.

Abstract: Provided are a computer program product, system, and method for hypervisor agnostic interchangeable backup recovery and file level recovery from virtual disks. Data is stored for a first virtual disk that represents data in a first format and metadata for the first virtual disk in a common data format in a storage having a fixed block length. A virtual disk file represents data in a second format that allows variable size blocks. Multiple instances of the fixed block length of blocks of data for the second virtual disk indicated in the virtual disk file are read. Each instance of the read fixed block length of blocks is written to the storage in the common data format with metadata describing the format of the blocks in the second virtual disk, and can be restored to a third virtual disk in the first or second format.

Abstract: For accessing files from block-level backups of a virtual disk, a system, method, computer program product and apparatus are disclosed. The system includes an apparatus with a changed block module that determines changed blocks between a previous and a current block-level backup of a virtual disk. A mapping module maps logical clusters of the virtual disk to the changed blocks and identifies files corresponding to the logical clusters. A changed file module designates files corresponding to the logical clusters as changed files, unless current attributes of files for the current backup match attributes of the files in a backup file index corresponding to the previous backup. The changed file module stores the current attributes and extents for changed files within blocks of a backup storage device for updating in the backup file index. The method and computer program product perform these functions and may use the system and the apparatus.

Abstract: For accessing files from block-level backups of a virtual disk, an apparatus is disclosed. The apparatus includes a changed block module that obtains a list of changed blocks between a previous and a current backup of a virtual disk. The apparatus includes a mapping module that maps logical clusters of the virtual disk to the changed blocks and identifies files corresponding to the logical clusters. The apparatus further includes a changed file module that designates the files corresponding to the logical clusters as changed files, unless current attributes of the files for the current backup match attributes of the files in a backup file index corresponding to the previous backup of the virtual disk. The changed file module further stores the current attributes and extents for the changed files within blocks of a backup storage device for updating in the backup file index.

Abstract: An apparatus, method and computer program product are disclosed. The apparatus includes a strategy module that determines restore information, writes the restore information into a restore information file, and writes the restore information file to a master volume containing target data; a snapshot module that creates a snapshot backup of the master volume; and a restoration module that restores the target data and restore information file, and restores application consistency of the target data. The method includes determining restore information, writing restore information to a file, writing the file to a volume containing data, backing up data by a snapshot backup of the volume, restoring data and the file, and restoring application consistency of the data. The computer program product comprises a computer readable storage medium that stores code to perform determining a backup strategy, backing up data, and restoring data.

Abstract: A method for executing complex data protection operations is disclosed. In one embodiment, such a method includes generating multiple complex data protection operations, where each complex data protection operation includes multiple data protection functions pre-arranged in a specified order and on a specified schedule. The method further presents the multiple complex data protection operations to a user in the form of a menu. This menu includes multiple menu options, where each menu option is associated with one of the complex data protection operations. The method further enables the user to select a menu option, and executes the complex data protection operation associated with the menu option selected by the user. A corresponding system and computer program product are also disclosed.

Abstract: An apparatus, method and computer program product are disclosed. The apparatus includes a strategy module that determines restore information, writes the restore information into a restore information file, and writes the restore information file to a master volume containing target data; a snapshot module that creates a snapshot backup of the master volume; and a restoration module that restores the target data and restore information file, and restores application consistency of the target data. The method includes determining restore information, writing restore information to a file, writing the file to a volume containing data, backing up data by a snapshot backup of the volume, restoring data and the file, and restoring application consistency of the data. The computer program product comprises a computer readable storage medium that stores code to perform determining a backup strategy, backing up data, and restoring data.

Abstract: In an approach to maintain data integrity in a computer data storage system, a clone management table is generated for a clone file tree that includes a relationship between at least one parent file and a clone file. The parent file is restored by: (i) determining that the parent-child relationship exists between the parent file and the clone file based on an entry in the clone management table, (ii) restoring data blocks in the parent file to the file system based on an analysis of an entry in the clone management table for the parent file and an identification of data blocks included in the clone file, and (iii) generating a new instance of the parent file based on the data blocks included in the file system and the entry in the clone management table for the clone file tree.