Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Abstract: A system can include one or more processors; memory; a data interface that receives data; a control interface that transmits control signals for control of pumps of a hydraulic fracturing operation; and one or more components that can include one or more of a modeling component that predicts pressure in a well fluidly coupled to at least one of the pumps, a pumping rate adjustment component that generates a pumping rate control signal for transmission via the control interface, a capacity component that estimates a real-time pumping capacity for each individual pump, and a control component that, for a target pumping rate for the pumps during the hydraulic fracturing operation, generates at least one of engine throttle and transmission gear settings for each of the individual pumps using an estimated real-time pumping capacity for each individual pump where the settings are transmissible via the control interface.

Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.

Abstract: Data can be serialized in such a manner as to facilitate later delta encoding, even when the serialization is performed using a lossy compression algorithm or an algorithm in which portions of the serialized data are encoded relative to other portions which may be modified. This can be achieved by approaches including preserving keyframe information across modified versions of a file, duplicating information from a previously created compressed file when serializing a later version, or adding change information showing differences between versions of a file during the serialization process.

Abstract: Data can be transferred between computers at remote sites by transferring the data itself, or by transferring files showing how data at an originating site can be recreated from data already present at a receiving site. As part of the data transfer, a determination can be made as to what is the most appropriate way for the transfer to take place. Further, in cases where data is not transferred directly between originating and receiving sites, it is possible that some preparatory steps might be performed to improve the efficiency of the transfers to the receiving sites when they do take place. Additional efficiencies can be obtained in some cases by using the parallel processing capabilities provided by a cloud based architecture.

Abstract: Data can be serialized in such a manner as to facilitate later delta encoding, even when the serialization is performed using a lossy compression algorithm or an algorithm in which portions of the serialized data are encoded relative to other portions which may be modified. This can be achieved by approaches including preserving keyframe information across modified versions of a file, duplicating information from a previously created compressed file when serializing a later version, or adding change information showing differences between versions of a file during the serialization process.

Abstract: Data can be serialized in such a manner as to facilitate later delta encoding, even when the serialization is performed using a lossy compression algorithm or an algorithm in which portions of the serialized data are encoded relative to other portions which may be modified. This can be achieved by approaches including preserving keyframe information across modified versions of a file, duplicating information from a previously created compressed file when serializing a later version, or adding change information showing differences between versions of a file during the serialization process.

Abstract: Data can be transferred between computers at remote sites by transferring the data itself, or by transferring files showing how data at an originating site can be recreated from data already present at a receiving site. As part of the data transfer, a determination can be made as to what is the most appropriate way for the transfer to take place. Further, in cases where data is not transferred directly between originating and receiving sites, it is possible that some preparatory steps might be performed to improve the efficiency of the transfers to the receiving sites when they do take place. Additional efficiencies can be obtained in some cases by using the parallel processing capabilities provided by a cloud based architecture.

Abstract: Data can be transferred between computers at remote sites by transferring the data itself, or by transferring files showing how data at an originating site can be recreated from data already present at a receiving site. As part of the data transfer, a determination can be made as to what is the most appropriate way for the transfer to take place. Further, in cases where data is not transferred directly between originating and receiving sites, it is possible that some preparatory steps might be performed to improve the efficiency of the transfers to the receiving sites when they do take place. Additional efficiencies can be obtained in some cases by using the parallel processing capabilities provided by a cloud based architecture.

Abstract: Data can be transferred between computers at remote sites by transferring the data itself, or by transferring files showing how data at an originating site can be recreated from data already present at a receiving site. As part of the data transfer, a determination can be made as to what is the most appropriate way for the transfer to take place. Further, in cases where data is not transferred directly between originating and receiving sites, it is possible that some preparatory steps might be performed to improve the efficiency of the transfers to the receiving sites when they do take place. Additional efficiencies can be obtained in some cases by using the parallel processing capabilities provided by a cloud based architecture.

Abstract: A low or no pollution engine is provided for delivering power for vehicles or other power applications. The engine has an air inlet which collects air from a surrounding environment. At least a portion of the nitrogen in the air is removed. The remaining gas is primarily oxygen, which is then routed to a gas generator. The gas generator has inputs for the oxygen and a hydrocarbon fuel. The fuel and oxygen are combusted within the gas generator, forming water and carbon dioxide. The combustion products are then expanded through a power generating device, such as a turbine or piston expander to deliver output power for operation of a vehicle or other power uses. The combustion products are then passed through a condenser where the steam is condensed and the carbon dioxide is collected or discharged. A portion of the water is routed back to the gas generator. The carbon dioxide is compressed and delivered to a terrestrial formation from which return of the CO2 into the atmosphere is inhibited.

Abstract: A low or no pollution engine is provided for delivering power for vehicles or other power applications. The engine has an air inlet which collects air from a surrounding environment. At least a portion of the nitrogen in the air is removed. The remaining gas is primarily oxygen, which is then routed to a gas generator. The gas generator has inputs for the oxygen and a hydrocarbon fuel. The fuel and oxygen are combusted within the gas generator, forming water and carbon dioxide. The combustion products are then expanded through a power generating device, such as a turbine or piston expander to deliver output power for operation of a vehicle or other power uses. The combustion products are then passed through a condenser where the steam is condensed and the carbon dioxide is collected or discharged. A portion of the water is routed back to the gas generator. The carbon dioxide is compressed and delivered to a terrestrial formation from which return of the CO2 into the atmosphere is inhibited.

Abstract: A low or no pollution engine is provided for delivering power for vehicles or other power applications. The engine has an air inlet which collects air from a surrounding environment. At least a portion of the nitrogen in the air is removed using a technique such as liquefaction, pressure swing adsorption or membrane based air separation. The remaining gas is primarily oxygen, which is then compressed and routed to a gas generator. The gas generator has an igniter and inputs for the high pressure oxygen and a high pressure hydrogen-containing fuel, such as hydrogen, methane or a light alcohol. The fuel and oxygen are combusted within the gas generator, forming water and carbon dioxide with carbon containing fuels. Water is also delivered into the gas generator to control the temperature of the combustion products. The combustion products are then expanded through a power generating device, such as a turbine or piston expander to deliver output power for operation of a vehicle or other power uses.

Abstract: A low or no pollution engine is provided for delivering power for vehicles or other power applications. The engine has an air inlet which collects air from a surrounding environment. At least a portion of the nitrogen in the air is removed using a technique such as liquefaction, pressure swing adsorption or membrane based air separation. The remaining gas is primarily oxygen, which is then compressed and routed to a gas generator. The gas generator has an igniter and inputs for the high pressure oxygen and a high pressure hydrogen-containing fuel, such as hydrogen, methane or a light alcohol. The fuel and oxygen are combusted within the gas generator, forming water and carbon dioxide with carbon containing fuels. Water is also delivered into the gas generator to control the temperature of the combustion products. The combustion products are then expanded through a power generating device, such as a turbine or piston expander to deliver output power for operation of a vehicle or other power uses.

Abstract: A low or no pollution engine is provided for delivering power for vehicles or other power applications. The engine has an air inlet which collects air from a surrounding environment. At least a portion of the nitrogen in the air is removed using a technique such as liquefaction, pressure swing adsorption or membrane based air separation. The remaining gas is primarily oxygen, which is then compressed and routed to a gas generator. The gas generator has an igniter and inputs for the high pressure oxygen and a high pressure hydrogen-containing fuel, such as hydrogen, methane or a light alcohol. The fuel and oxygen are combusted within the gas generator, forming water and carbon dioxide with carbon containing fuels. Water is also delivered into the gas generator to control the temperature of the combustion products. The combustion products are then expanded through a power generating device, such as a turbine or piston expander to deliver output power for operation of a vehicle or other power uses.

Abstract: A low or no pollution engine is provided for delivering power for vehicles or other power applications. The engine has an air inlet which collects air from a surrounding environment. At least a portion of the nitrogen in the air is removed using a technique such as liquefaction, pressure swing adsorption or membrane based air separation. The remaining gas is primarily oxygen, which is then compressed and routed to a gas generator. The gas generator has an igniter and inputs for the high pressure oxygen and a high pressure hydrogen-containing fuel, such as hydrogen, methane or a light alcohol. The fuel and oxygen are combusted within the gas generator, forming water and carbon dioxide with carbon containing fuels. Water is also delivered into the gas generator to control the temperature of the combustion products. The combustion products are then expanded through a power generating device, such as a turbine or piston expander to deliver output power for operation of a vehicle or other power uses.

Abstract: A low or no pollution engine is provided for delivering power for vehicles or other power applications. The engine has an air inlet which collects air from a surrounding environment. At least a portion of the nitrogen in the air is removed using a technique such as liquefaction, pressure swing adsorption or membrane based air separation. The remaining gas is primarily oxygen, which is then compressed and routed to a gas generator. The gas generator has an igniter and inputs for the high pressure oxygen and a high pressure hydrogen-containing fuel, such as hydrogen, methane or a light alcohol. The fuel and oxygen are combusted within the gas generator, forming water and carbon dioxide with carbon containing fuels. Water is also delivered into the gas generator to control the temperature of the combustion products. The combustion products are then expanded through a power generating device, such as a turbine or piston expander to deliver output power for operation of a vehicle or other power uses.