Abstract: Disclosed herein are crystalline forms of (4S,7aR,9aR,10R,11E,14S,15R)-6?-chloro-10-methoxy-14,15-dimethyl-10-{[(9aR)-octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]methyl}-3?,4?,7a,8,9,9a,10,13,14,15-decahydro-2?H,3H,5H-spiro[1,19-etheno-1616-cyclobuta[i] [1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1?-naphthalene]-16,16,18(7H,17H)-trione (AMG 397): (AMG 397), hydrates, and solvates thereof. Also disclosed are methods of making the crystalline forms, and methods of treating diseases and disorders with the crystalline forms.

Abstract: A bar tapping tool for use during a tap swing drill includes a plurality of bristles adjacent one another and extending horizontally so as to signal when the gymnast should begin her bodily shape change while keeping a safe distance from lower bar. The bar tapping tool has bristles of different lengths extending horizontally so that an athlete swinging on the upper bar can at first swing at a farther distance away from the lower bar and then later, when more experienced, swing at a closer distance away from the lower bar.

Abstract: A bar tapping tool for use during a tap swing drill includes a plurality of bristles adjacent one another and extending horizontally so as to signal when the gymnast should begin her bodily shape change while keeping a safe distance from lower bar. The bar tapping tool has bristles of different lengths extending horizontally so that an athlete swinging on the upper bar can at first swing at a farther distance away from the lower bar and then later, when more experienced, swing at a closer distance away from the lower bar.

Abstract: An arm training band includes a strap having an elongate configuration and a pair of opposed loops coupled to opposite ends of the strap. The loops are specifically configured to fit or hook over a thumb of a user who is wearing the arm training band. The strap may be extended around the upper arm of the user proximate the user's elbow and the loops hooked over the user's thumb. Preferably, the user will wear an arm training band on each arm when training and practicing proper arm positioning when running.

Abstract: A parallettes apparatus is portable and configured to allow an athlete to exercise even when remote from a traditional gymnastics training facility. The portable parallettes apparatus includes a pair of base members and a bar member removably extending between respective base members. The pair of base members are hollow and configured to receive the bar during transport or storage.

Abstract: A transition trampoline apparatus includes a transition trampoline bed having an elongate configuration that, when mounted on support legs, provides a track for a gymnast that is sufficiently bouncy to ease wear and tear on a gymnast's knees and ankles while not affecting her footwork while running and doing gymnastic maneuvers.

Abstract: An arm training band includes a strap having an elongate configuration and a pair of opposed loops coupled to opposite ends of the strap. The loops are specifically configured to fit or hook over a thumb of a user who is wearing the arm training band. The strap may be extended around the upper arm of the user proximate the user's elbow and the loops hooked over the user's thumb. Preferably, the user will wear an arm training hand on each arm when training and practicing proper arm positioning when running.

Abstract: A parallettes apparatus is portable and configured to allow an athlete to exercise even when remote from a traditional gymnastics training facility. The portable parallettes apparatus includes a pair of base members and a bar member removably extending between respective base members. The pair of base members are hollow and configured to receive the bar during transport or storage.

Abstract: A transition trampoline apparatus includes a transition trampoline bed having an elongate configuration that, when mounted on support legs, provides a track for a gymnast that is sufficiently bouncy to ease wear and tear on a gymnast's knees and ankles while not affecting her footwork while running and doing gymnastic maneuvers.

Abstract: A miniature trampoline includes a frame having at least a pair of spaced apart upper frame members each having an upper front end and an upper rear end, respectively, the upper frame members being inclined toward the upper rear ends, respectively. A trampoline bed includes at least one planar surface and a pair of elongate side edges situated between the upper frame members and extending substantially between the upper rear ends and upper front ends of the pair of upper frame members, respectively. The trampoline includes a plurality of springs, each spring having a spring fastener coupled to a respective upper frame member and a bed fastener coupled to the trampoline bed proximate a side edge thereof, wherein the springs are spaced apart along the respective upper frame members, respectively, such that the trampoline bed is selectively held in tension between the upper frame members, respectively.

Abstract: A miniature trampoline includes a frame having at least a pair of spaced apart upper frame members each having an upper front end and an upper rear end, respectively, the upper frame members being inclined toward the upper rear ends, respectively. A trampoline bed includes at least one planar surface and a pair of elongate side edges situated between the upper frame members and extending substantially between the upper rear ends and upper front ends of the pair of upper frame members, respectively. The trampoline includes a plurality of springs, each spring having a spring fastener coupled to a respective upper frame member and a bed fastener coupled to the trampoline bed proximate a side edge thereof, wherein the springs are spaced apart along the respective upper frame members, respectively, such that the trampoline bed is selectively held in tension between the upper frame members, respectively.

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: In one aspect, the invention provides methods of inhibiting the effects of lectin-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MAp19 inhibitory agent effective to inhibit lectin-dependent complement activation. In some embodiments, the MAp19 inhibitory agent inhibits cellular injury associated with lectin-mediated complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides MAp19 specific antibodies that do not bind to MASP-2 and methods of producing MAp19 specific antibodies. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MAp19 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASp-2 inhibitory agent and a pharmaceutically acceptable carrier.