Abstract: A device may A) obtaining plural pieces of training data each of which being an indicator of a periprosthetic joint infection, wherein the plural pieces of training data include at least one combination of data indicating a high probability of a periprosthetic joint infection. A device may B) using the plural pieces of training data to pre-train a machine learning model. A device may C) wherein the plural pieces of training data of B) correspond to a combination of data that is associated with periprosthetic joint infection. A device may D) feeding plural pieces of data obtained from a subject to the machine learning model. A device may E) determining the likelihood of a subject having a periprosthetic joint infection based on an output of the machine learning model.

Abstract: The invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The invention is directed to methods of treatment using compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The invention is directed to certain novel compounds. Specifically, crystalline forms of N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide and crystalline 6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole, along with salts thereof.

Abstract: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.

Abstract: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.

Abstract: The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.

Abstract: The invention provides a combination comprising compounds of formula (I) or salts thereof, and one or more therapeutic agents.

Abstract: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.

Abstract: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.

Abstract: The present invention is directed to a polymorph of a compound and salts of a compound and polymorphs thereof, which compound is an inhibitor of kinase activity.

Abstract: A method includes: assembling first and second pieces in a slip-fit joint without applying adhesive or sealant, wherein the first piece covers a portion of the second piece in the slip-fit joint; and injecting adhesive through the first piece until the adhesive fills a gap of the slip-fit joint, wherein the adhesive makes the slip-fit joint air tight without applying the sealant. An air-tight slip-fit joint consists essentially of: first and second pieces assembled without applying adhesive or sealant, wherein the first piece covers a portion of the second piece in the slip-fit joint; and adhesive injected through the first piece until the adhesive fills a gap of the slip-fit joint, wherein the adhesive makes the slip-fit joint air tight without applying the sealant.

Abstract: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.

Abstract: The invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.