Abstract: The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.

Abstract: A tool for removing particle residue from a cylindrical container includes a handle, configured to be grasped in the hand of a user to position the tool and to rotate the tool around an axis of rotation aligned substantially parallel to the handle, and at least one blade section extending from the handle at an angle to the axis of rotation. A user manipulates the handle in use to cause the tool to rotate about the axis of rotation so that the leading edge of the blade section moves into and through compacted particle residue within the cylindrical container.

Abstract: Antimicrobially effective compositions comprising lactic acid, salicylic acid, and at least one anionic surfactant are provided. The compositions are effective in controlling pathogen levels, particularly those commonly found on bovine teats to prevent or reduce the incidence of mastitis in lactating cows. In particular, the compositions possess germicidal and/or yeasticidal characteristics. Methods of using the antimicrobial compositions, as a part of a good milking routine, are also provided in which the compositions are applied to bovine teats.

Abstract: The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of hemoglobin, and methods for their use in treating disorders mediated by hemoglobin.

Abstract: A tool for removing particle residue from a cylindrical container includes a handle, configured to be grasped in the hand of a user to position the tool and to rotate the tool around an axis of rotation aligned substantially parallel to the handle, and at least one blade section extending from the handle at an angle to the axis of rotation. A user manipulates the handle in use to cause the tool to rotate about the axis of rotation so that the leading edge of the blade section moves into and through compacted particle residue within the cylindrical container.

Abstract: The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of hemoglobin, and methods for their use in treating disorders mediated by hemoglobin.

Abstract: Nanoscale or mesoscale structures are fabricated on the surface of a substrate (e.g. silicon) by the aggregation of atomic clusters (e.g. antimony or bismuth) into V-grooves. These structures, preferably in the form of nanowires, are used as etching masks for the subsequent etching of the substrate. In an embodiment the V-grooves are metallised (e.g. with titanium or gold) prior to the deposition of the clusters. In this case the use of the nanostructures (e.g. antimony or bismuth) as an etching mask results in the formation of nanostructures of the underlying metal (e.g. titanium or gold). In this way the dimensions of the nanowires are transferred into the underlying metal film and the method allows fabrication of nanowires from materials (e.g. titanium or gold) that cannot be deposited as clusters.

Abstract: Methods of preparing electrically conducting wire-like structures for use in for example electronic devices, and the devices formed by such methods are described. One example of such a method of preparing said structures relies on the assembly of conducting particles using surface templates to assist in the formation of a wire-like structure. Said structures may be prepared on the nanoscale, but also up to the micronscale.

Abstract: A system and method for passing Direct Memory Access (DMA) configuration information from one device driver to another in order to initialize devices for DMA operations are provided. More specifically, a mechanism for passing information, identifying a DMA address space allocated to a child virtual device, from the child virtual device to the virtual I/O (VIO) bus is provided so that DMA operations may be initialized for the child virtual device via the VIO bus. With the system and method, the device driver of the child virtual device passes information regarding the DMAble address space of the child virtual device directly to the device driver of the VIO bus using one of a I/O control (IOCTL) interface and an operating system kernel service. This information is then used by the VIO bus device driver to setup the VIO bus for DMA operations from the child virtual device.

Abstract: A silver recovery and monitoring system including a sensor for transmitting a silver concentration signal in response to the concentration of silver in a fluid, means for determining whether the silver concentration signal indicates the concentration of silver in the fluid to be above a predetermined silver level and for initiating a silver alert signal in response to a determination that the silver concentration signal indicates the concentration of silver in the fluid to be above the predetermined silver level, and means for transmitting a notification signal to a silver monitoring station in response to the silver alert signal.

Abstract: Apparatus and methods for monitoring of dissolved (ionic) heavy metal residuals in liquid process stream or liquid waste (effluent) streams, as examples, after recovery and collection of such metals from a laboratory, medical, industrial or manufacturing process stream. An automatic controller is employed to deliver a sample volume of liquid from the stream to a measurement chamber, adjust the conductivity of the sample volume within the measurement chamber to a predetermined conductivity at a predetermined conductivity measurement temperature, employ an ion specific electrode and a reference electrode to make a voltage measurement representative of the concentration of specific metal ions within the sample volume at the predetermined concentration measurement temperature, record the voltage measurement, and flush the measurement chamber.