Abstract: A wearable cardiac monitoring and treatment device for improved skin interface contact and easy assembly and disassembly includes a garment including an inner surface and an outer surface, ECG sensing electrodes, and at least one stiffener forming a section of the garment in proximity to one or more of the ECG sensing electrodes. The at least one stiffener is configured to resist rotation or pulling away of the one or more of the ECG sensing electrodes from a patient's torso. The device includes therapy electrodes, at least one separate module including a therapy delivery circuit, and a controller. The device includes compartments configured to receive the therapy electrodes and at least one separate module, and retention loops configured to route external wires extending between at least the therapy electrodes and at least one separate module, where the compartments and retention loops are disposed on the outer surface of the garment.

Abstract: A resistor module includes a resistor module housing having an inner cavity. A proximity contact and a ground contact are received in the inner cavity and held by the resistor module housing. A proximity wire, electrically connected to a proximity terminal of the charging inlet assembly, is electrically connected to the proximity contact. A ground wire, electrically connected to a ground terminal of the charging inlet assembly, is electrically connected to the ground contact. A resistor element is received in the inner cavity and coupled to mating ends of the proximity and ground contacts. The resistor element is electrically connected to the proximity terminal through the proximity wire and the proximity contact and is electrically connected to the ground terminal through the ground wire and the ground contact.

Abstract: The present invention provides engineered platelets with chimeric platelet receptors (CPR) with a desired target specificity. Additionally, the engineered platelets may comprise cargo which may be released upon activation of the platelet. Additionally, the platelets may be generated in vitro from megakaryocytes engineered to generate non-thrombogenic platelets.

Abstract: An externally worn cardiac monitoring and/or treatment system with battery detachment detection is provided. The system includes detachment circuitry and audible and/or vibrational alarm circuitry operably coupled to the detachment circuitry. The detachment circuitry is configured to detect whether the rechargeable battery is detached from the battery-powered externally worn cardiac device by monitoring a connection established between the rechargeable battery and the at least one processor and output a battery status signal indicating whether the rechargeable battery is detached from the battery-powered externally worn cardiac device. The audible and/or vibrational alarm circuitry is configured to receive the battery status signal and output an audible alert in a predetermined frequency range and/or a tactile alert if the rechargeable battery is detached.

Abstract: A patient-worn arrhythmia monitoring and treatment device includes an anterior adhesively coupled pad, a posterior adhesively coupled pad, and a wearable support integrated with the anterior and posterior adhesively coupled pads. The wearable support is configured to bear at least a portion of the weight of at least one of the anterior adhesively coupled pad or the posterior adhesively coupled pad. The device also includes a pair of therapy electrodes configured to deliver one or more therapeutic pulses, a plurality of ECG sensing electrodes, a first housing, a second housing, an ECG acquisition and conditioning circuit, a therapy delivery circuit, and a processor. The processor is configured to analyze the at least one ECG signal of the patient, detect one or more treatable arrhythmias, and cause the therapy delivery circuit to deliver up to five therapeutic pulses to the patient.

Abstract: A patient-worn arrhythmia monitoring and treatment device weight between 250 grams and 2,500 grams includes at least one contoured pad configured to be adhesively coupled to a patient's torso, a plurality of therapy electrodes, at least one of which is integrated with the at least one contoured pad, and a plurality of ECG sensing electrodes, at least one of which is integrated with the at least one contoured pad. At least one housing configured to form a watertight seal with the at least one contoured pad extends no more than 5 cm from the contoured pad. A processor disposed within the housing is coupled to a therapy delivery circuit and configured to detect one or more treatable arrhythmias based on at least one ECG signal and cause a therapy delivery circuit to deliver at least one defibrillation pulse on detecting the one or more treatable arrhythmias.

Abstract: An externally worn cardiac monitoring and/or treatment system with battery detachment detection is provided. The system includes detachment circuitry and audible and/or vibrational alarm circuitry operably coupled to the detachment circuitry. The detachment circuitry is configured to detect whether the rechargeable battery is detached from the battery-powered externally worn cardiac device by monitoring a connection established between the rechargeable battery and the at least one processor and output a battery status signal indicating whether the rechargeable battery is detached from the battery-powered externally worn cardiac device. The audible and/or vibrational alarm circuitry is configured to receive the battery status signal and output an audible alert in a predetermined frequency range and/or a tactile alert if the rechargeable battery is detached.

Abstract: Embodiments of the present disclosure are directed to a rotor assembly for use in a radial flux electric motor assembly having core magnets rotatable relative to end magnets such that the torque constant of the rotor assembly varies. The plurality of end magnets is positioned over the core magnets when the rotor assembly is at rest and the rotor assembly has a first torque constant at rest. The plurality of end magnets can rotate relative to the core magnets upon application of torque to the rotor assembly.

Abstract: A wearable cardiac monitoring and treatment device includes a garment, a plurality of ECG electrodes, a plurality of therapy electrodes, a therapy delivery circuit, and one or more sensors configured to monitor one or more physiological signals of the patient. The device also includes a controller configured to detect an arrhythmia condition, cause the therapy delivery circuit to deliver one or more therapeutic pulses to the patient on detecting the arrhythmia condition, detect that the garment is no longer worn about the torso of the patient prior to expiration of at least a prescribed duration of wear by detecting a loss of signal for at least a threshold period of time from one or more of the plurality of ECG sensing electrodes and/or one or more of the one or more sensors, and issue a notification that the garment is no longer worn about the torso of the patient.

Abstract: The present invention provides engineered platelets with chimeric platelet receptors (CPR) with a desired target specificity. Additionally, the engineered platelets may comprise cargo which may be released upon activation of the platelet. Additionally, the platelets may be generated in vitro from megakaryocytes engineered to generate non-thrombogenic platelets.

Abstract: System and methods for providing a patient with arrhythmia treatment are described. For example, a system includes an arrhythmia monitoring and treatment assembly configured to be worn on the torso of the patient. The assembly has a housing discreetly extending from a skin surface of the patient. The assembly is configured to provide therapy on detecting one or more arrhythmia conditions of the patient. A first at least one user response button is disposed on the assembly at a first location on the torso concealed under clothing, and a second at least one user response button is configured to be worn on a second location of the patient's body, a location other than the torso that is accessible to the patient. The system suspends an impending therapy upon receiving a user input from either one of the first or second at least one user response buttons.

Abstract: A rotor assembly for use in a radial flux electric motor assembly includes a rotor core having a plurality of rotor poles circumferentially spaced about a central axis, wherein the rotor core includes a first end and an opposing second end. The rotor assembly further includes a plurality of core magnets alternately spaced with the plurality of rotor poles. The plurality of rotor poles define a radial aperture between each pair of circumferentially adjacent rotor poles, and each radial aperture is configured to receive at least one core magnet of the plurality of core magnets therein. A plurality of end magnets are coupled to at least one of the first end and the second end, and at least one end plate coupled to the plurality of end magnets.

Abstract: A wearable cardiac monitoring and treatment device for improved skin interface contact and easy assembly and disassembly includes a garment including an inner surface and an outer surface, ECG sensing electrodes, and at least one stiffener forming a section of the garment in proximity to one or more of the ECG sensing electrodes. The at least one stiffener is configured to resist rotation or pulling away of the one or more of the ECG sensing electrodes from a patient's torso. The device includes therapy electrodes, at least one separate module including a therapy delivery circuit, and a controller. The device includes compartments configured to receive the therapy electrodes and at least one separate module, and retention loops configured to route external wires extending between at least the therapy electrodes and at least one separate module, where the compartments and retention loops are disposed on the outer surface of the garment.

Abstract: The present invention provides engineered platelets with chimeric platelet receptors (CPR) with a desired target specificity. Additionally, the engineered platelets may comprise cargo which may be released upon activation of the platelet. Additionally, the platelets may be generated in vitro from megakaryocytes engineered to generate non-thrombogenic platelets.

Abstract: The present invention provides engineered platelets with chimeric platelet receptors (CPR) with a desired target specificity. Additionally, the engineered platelets may comprise cargo which may be released upon activation of the platelet. Additionally, the platelets may be generated in vitro from megakaryocytes engineered to generate non-thrombogemc platelets.

Abstract: Field games comprise a playing field having a defined area at only one end of the playing field, and a remaining area. The defined area is configured to accommodate a player having possession of a ball therein, and may be configured to prevent entry from one or more direction, or may be configured to permit access from all sides. The field game may be played by two teams of players, initially positioned at different locations of the playing field, where one team has the objective of putting one or more of its players in the defined area with possession of one or more balls and thereby scoring, and where the other team has the objective of trying to prevent the opposite team from its objective of scoring. Teams switch objectives after the team in possession scores with its balls and/or loses possession of its balls, and play is quickly resumed.

Abstract: The present disclosure provides methods and compositions for generating populations of auxotrophic cells and populations of differentiated cells and selecting populations of transfected cells using split auxotrophy.

Abstract: The present disclosure provides compositions and methods for producing and using modified auxotrophic host cells for improved therapy involving administration of an auxotrophic factor.

Abstract: The present invention provides engineered platelets with chimeric platelet receptors (CPR) with a desired target specificity. Additionally, the engineered platelets may comprise cargo which may be released upon activation of the platelet. Additionally, the platelets may be generated in vitro from megakaryocytes engineered to generate non-thrombogemc platelets.

Abstract: The present invention provides engineered platelets with chimeric platelet receptors (CPR) with a desired target specificity. Additionally, the engineered platelets may comprise cargo which may be released upon activation of the platelet. Additionally, the platelets may be generated in vitro from megakaryocytes engineered to generate non-thrombogenic platelets.