Abstract: Non-limiting examples describe automated bundling of content on behalf of a user by an application/service. As an example, a bundle of content may be a bundle of emails created on behalf of a user by an email service. Email data associated with a user account of an email service may be accessed. The email data may be evaluated by applying a bundle generation model that that evaluates the emails for bundling associations. An exemplary bundle generation model may evaluate the email data based on: user signal data from actions pertaining to categorization of specific emails, content and metadata corresponding with the email data, and server side metric analysis of activity corresponding with the user account. A bundle of emails may be automatically generated based on an evaluation result from applying the bundle generation model. The bundle of emails may be transmitted for display in a mailbox of the user account.

Abstract: Non-limiting examples describe sharing of bundled content through an application/service. A first input may be received, through a user interface of the email service. The first input is associated with a selection of a user interface element for sharing of a bundle of emails that comprises a grouping of at least two separate email threads. A second input is received indicating one or more other users for sharing the bundle of emails. The bundle of emails is shared with the one or more other users. Sharing of the bundle of emails creates a sharing permission that enables multi-directional sharing between the user and the one or more other users for current content of the shared bundle of emails and future content added to the shared bundle of emails. The shared bundle of emails is displayed inline with other emails of an email mailbox of the user through the user interface.

Abstract: Provided are methods, uses and pharmaceutical compositions for treatment of cancer with a B1SP fusion protein in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The cancer may be prostate cancer, breast cancer, ovarian cancer, bladder cancer, kidney cancer, glioblastoma or endometrial cancer. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the B1SP fusion protein may include a sema domain, a structural stabilization domain; and a half life extending moiety.

Abstract: Systems for determining and presenting consensus based on evaluating a message conversation are described. A consensus determination application may automatically parse each message of a series of messages related to a topic, using natural language processing or similar methods, to determine one or more suggestions and corresponding opinions for the one or more suggestions contained within those messages. The consensus for each of the one or more suggestions may be presented to a user. By viewing the automatically-determined consensus, the user may, without reading and evaluating all of the messages within the conversation, understand the level of consensus regarding the topic across the group of message participants. Accordingly, user burden is reduced and users may more effectively debate ideas and present suggestions with fewer misunderstandings, leading to an overall better user experience.

Abstract: An electronic mail (email) system generates an email user interface display for composing an email message. A context-sensitive widget display is surfaced, on the user interface display, in-line with other message content. A widget that generates the widget display interacts with a remote data service to surface data from the remote data service, on the widget display.

Abstract: An electronic mail (email) system generates an email user interface display, that allows the user to enter message content. A context-sensitive calendar preview can be triggered and displayed on the email user interface display. The email system detects a user drag and drop input dragging at least a portion of the message content onto the calendar preview, and automatically generates a calendar event based upon the detected drag and drop input, and the particular portion of the message content dragged onto the context-sensitive calendar preview.

Abstract: A neutral or acidic automatic dishwashing detergent composition including a perfume wherein the perfume includes at least one ester-including perfume raw material having the following formula: wherein R1 and R2 are independently selected from: i) unbranched linear alkyls or alkenyls; and ii) branched linear alkyls or alkenyls wherein if the branching is in an alpha or beta position the branching is CH3 or a pendant cyclic group.

Abstract: A household liquid-dispensing container such as a drinking vessel or a jug comprising a vessel (30) that is configured to hold a liquid and that has a base (37) on which it can stand, an opening (39) and at least one side (38); and a handle (50) that is configured to be held by a user and that is attached to a side of the vessel (38) by a joint that forms a single gimbal between the handle (50) and the vessel (30) and that allows the handle (50) to pivot about a single axis (21) that extends directly above the center of gravity of the vessel (30) when the vessel base (37) is standing on a horizontal surface; an optional baffle assembly (80) to reduce sloshing; and a lid (120).

Abstract: Packaging for electronic components includes provisions to short selected electrodes of the components together. A plastic base portion with a plurality of component receiving cavities carries a flexible, carbonized shorting element which extends between cavities. The cavities include a recess which is adjacent to the shorting element. Components can be inserted into respective cavities, and some of the electrodes will contact the shorting element. Other electrodes will extend into the recess and not be shorted.

Abstract: An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing & diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs.

Abstract: Provided are methods, uses and pharmaceutical compositions for treatment of prostate cancer with a SEMA3C inhibitor in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the SEMA3C inhibitor may be selected from one or more of the following: an antibody, a SEMA3C peptide, an antisense RNA, a siRNA, a shRNA or a small molecule.

Abstract: Provided are methods, uses and pharmaceutical compositions for treatment of prostate cancer with a SEMA3C inhibitor in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the SEMA3C inhibitor may be selected from one or more of the following: an antibody, a SEMA3C peptide, an antisense RNA, a siRNA, a shRNA or a small molecule.

Abstract: A household liquid-dispensing container such as a drinking vessel or a jug comprising a vessel (30) that is configured to hold a liquid and that has a base (37) on which it can stand, an opening (39) and at least one side (38); and a handle (50) that is configured to be held by a user and that is attached to a side of the vessel (38) by a joint that forms a single gimbal between the handle (50) and the vessel (30) and that allows the handle (50) to pivot about a single axis (21) that extends directly above the centre of gravity of the vessel (30) when the vessel base (37) is standing on a horizontal surface: an optional baffle assembly (80) to reduce sloshing; and a lid (120).

Abstract: Provided are methods, uses and pharmaceutical compositions for treatment of prostate cancer with a SEMA3C inhibitor in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the SEMA3C inhibitor may be selected from one or more of the following: an antibody, a SEMA3C peptide, an antisense RNA, a siRNA, a shRNA or a small molecule.

Abstract: A multi-layered web is provided that includes an elastic web bonded to an inelastic web. The inelastic web has extensible and inextensible regions arranged along the machine direction. In the extensible regions, the inelastic web is bonded to the elastic web in a creped structure that is extensible by virtue of the creping. A continuous process is provided to manufacture a multi-layer web having extensible regions that are conjoined with regions that are inextensible by varying the tension that is applied during manufacture of the multi-layer web. The apparatus comprises an elastic web that is fed into a bonding nip, into which one or more inelastic webs are also provided. The elastic web is fed into the bonding nip under a tension that is alternated between a low value that is sufficient to ensure processing stability, and a higher value that provides an elongation to the elastic web.

Abstract: A stabilising drinking device, including a handle (21) attached within a set range of points to an outer ring (20) that pivots about a middle ring (30) that orthogonally pivots about a cradle (40) within which a cup (50) resides, and all parts made at such dimensions to enable the mechanism to lock when the handle is sufficiently turned to pour drinks into users' mouths.

Abstract: The present invention relates, in general, to a method of enhancing an immune response in a mammal and, in particular, to a method of enhancing an immune response to a vaccine comprising suppressing the number and/or function of regulatory T cells. The invention further relates to compounds and compositions suitable for use in such a method.

Abstract: A method for producing a composite web includes supplying two or more webs to an activation mechanism, where the webs are in an unbonded state relative to each other. The method further entails simultaneously activating the webs while they are in a face to face relationship and in an unbonded state, and then bonding the webs to form a composite web.

Abstract: A system is provided for providing vascular access across chronic total occlusions, in particular those that are particularly long such as in the lower periphery. A guide wire has an off-set, tilted tip section that provides rotational micro-dissection through tight CTO lesions. An outer catheter sheath prevents binding of the wire via wire reinforced composite polymeric construction. The outer sheath catheter includes an ablative outer surface for ablating tissue in contact therewith. The guide wire and outer sheath catheter are each driven by an actuator for cooperative advancement through the CTO. Rotational couplers rotate them, which may be at different speeds and via different couplers. The engagement of the wire within the sheath may allow for at least limited longitudinal movement between them during CTO advancement.

Abstract: Disclosed herein are various open/closed stent designs and methods for creating the same that can be individually adopted depending on particular treatment objectives. Specifically, the stents of the present invention are manufactured to include different open/closed configurations along their length by varying the number of crossovers, connectors or weld points between sections of the stent. Open portions contain less crossovers, connectors or weld points and are more flexible than closed portions which contain more crossovers, connectors or weld points.