Abstract: Abuse-resistant opioid compounds, drug delivery systems, pharmaceutical compositions comprising an opioid covalently bound to a chemical moiety are provided. Methods of delivering an active ingredient to a subject and methods of preventing opioid abuse are also provided.

Abstract: Embodiments of magnetic resonance eye tracking systems and methods are disclosed. One embodiment, among others, comprises a method that receives magnetic resonance based data and determines direction of a subject's gaze based on the data.

Abstract: A cylinder head of an engine is disclosed, the cylinder head including an upper deck, a lower deck, and a sidewall extending between the upper deck and the lower deck. The lower deck defines a block-engaging portion and a combustion chamber flame deck. The combustion chamber flame deck is spaced apart from the block-engaging portion. An engine is also disclosed that includes a cylinder block having a cylinder bore, and a piston slidably positioned within the cylinder bore. The engine also includes a cylinder head having a lower deck connected to the cylinder block, the lower deck defining a block-engaging portion and a combustion chamber flame deck. The combustion chamber flame deck is spaced apart from the block-engaging portion by a recess.

Abstract: An internal combustion engine is provided that includes a high pressure feed line, and a plurality of fuel injectors fluidly connected to the high pressure feed line, each being operable to inject a fuel into the engine. The engine further includes an electronically controlled flow disabler disposed between the high pressure feed line and each one of the fuel injectors. Each of the flow disablers includes an actuator operable to move a valve member toward a closed position at which the flow disabler blocks a fuel flow to the respective fuel injector.