Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a prion protein (PRNP) gene, as well as methods of inhibiting expression of a PRNP gene and methods of treating subjects having a PRNP-associated disease or disorder, e.g., Prion diseases, using such dsRNAi agents and compositions.

Abstract: The techniques of this disclosure enable frequency-modulated continuous-wave radar-based detection of living objects. Instead of generating a chirp pattern with each chirp separated by an idle period, a radar generates a chirp pattern with multiple chirps separated by an idle period. From applying a Fourier transform to receiver signals for each frame, the radar determines an amplitude as a function of range for each frame. The radar computes the standard deviation between the amplitudes of two frames and then, for each additional frame, the radar incrementally updates the standard deviation to be inclusive of the amplitude contribution of the additional frame. That is, rather than recalculate the standard deviation for each new frame, the radar increments the standard deviation by a fraction of the amplitude for the new frame, which is proportionate to the total quantity of frames generated thus far.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing neural architecture search for machine learning models. In one aspect, a method comprises receiving training data for a machine learning, generating a plurality of candidate neural networks for performing the machine learning task, wherein each candidate neural network comprises a plurality of instances of a layer block composed of a plurality of layers, for each candidate neural network, selecting a respective type for each of the plurality of layers from a set of layer types that comprises, training the candidate neural network and evaluating performance scores for the trained candidate neural networks as applied to the machine learning task, and determining a final neural network for performing the machine learning task based at least on the performance scores for the candidate neural networks.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: A heat press docking station base (52) comprises a nest portion (75) and one or more legs (58). The nest portion (52) includes a body shell (60, 62) and a perforated floor (54). The body shell (60, 62) includes a lower surface (63). The perforated floor (54) is connected to the body shell (60, 62). The one or more legs (58) extend from a lower surface (63) of the body shell (60, 62).

Abstract: A mug wrapping machine for sublimation transfer printing includes a base plate, above which a clamping frame mounting plate, a pressing plate, an auxiliary plate and a lifting plate are sequentially arranged. A placing plate is arranged above the lifting plate, so that the lower surface of the placement plate is provided with guide posts passing through the lifting plate, the auxiliary plate, the holding plate and the mounting plate of the clamping frame, and the lower end of the guide column is fixed on the upper surface of the base plate. The mounting plate of the clamping frame is installed between the clamping plate and the front and rear ends of the upper surface of the pressing plate, respectively, with ear seats, and a circular center column is arranged between the two ear seats, and the two ends of the circular center column are respectively equipped with rotating plates.

Abstract: This document relates to methods and materials involved in treating cancer. For example, methods and materials for using one or more oncolytic viruses (e.g., one or more replicating oncolytic viruses) to treat cancer in a mammal (e.g., a human) identified as having a cancer likely to respond to oncolytic virotherapy are provided.

Abstract: A display system may include a light source that emits input light having a wavelength within a source wavelength range and an array of color conversion units overlapping a display area. A first set of color conversion units of the array of color conversion units may include a first color conversion medium that converts the input light to a first color of light having a wavelength within a first wavelength range that is different than the source wavelength range. The display system may also include a waveguide having an out-coupler that directs the input light from the light source toward the array of color conversion units. Various other devices, systems, and methods are also disclosed.

Abstract: Described herein are techniques are provided for enabling a security orchestration, automation, and response (SOAR) service to automatically manage apps used to interface with an integrated security operations service and other related devices and services. Further described herein is a SOAR app generator service or application used to automate the creation of apps for a SOAR service based on application programming interfaces (API) specifications for related devices or services, as well as visual playbook editor interfaces for a SOAR service that enable the configuration of complex action input parameters including arrays and objects.

Abstract: Embodiments disclosed herein provide systems, methods, and computer readable media to access data on removable storage media via a network attached access device. In a particular embodiment, a method provides receiving one or more user provided, in the removable storage media access device, receiving data over a packet communication network for storage on a removable storage medium. After receiving the data, the method provides preparing the data for storage on the removable storage medium. After preparing the data, the method provides writing the data to the removable storage medium.

Abstract: Embodiments disclosed herein provide systems, methods, and computer readable media to access data on removable storage media via a network attached access device. In a particular embodiment, a method provides receiving one or more user provided, in the removable storage media access device, receiving data over a packet communication network for storage on a removable storage medium. After receiving the data, the method provides preparing the data for storage on the removable storage medium. After preparing the data, the method provides writing the data to the removable storage medium.

Abstract: A magnetic tape device or system can store erasure encoded data that generates a multi-dimensional erasure code corresponding to an erasure encoded object comprising a code-word (CW). The multi-dimensional erasure code enables using a single magnetic tape in response to a random object/file request, and correct for an error within the single magnetic tape without using other tapes. Encoding logic can further utilize other magnetic tapes to generate additional parity tapes that recover data from an error of the single magnetic tape in response to the error satisfying a threshold severity for a reconstruction of the erasure coded object or chunk(s) of the CW. The encoding logic can be controlled, at least in part, by one or more iterative coding processes between multiple erasure code dimensions that are orthogonal to one another.

Abstract: Methods, systems, and devices of a charging scheduler are provided for a vehicle that generates a charging schedule based on home power usage, user charging preferences, user schedule, vehicle information, and/or power provider attributes. The charging scheduler allows a user of a vehicle to connect the vehicle to a charging station and for the charging station to charge the rechargeable energy storage of the vehicle during charging time periods specified in the charging schedule without further user interaction. According to one embodiment, the charging scheduler may use power provider attributes for power costs per time of day and/or for home power usage costs to reduce the cost of charging the rechargeable energy storage of the vehicle. The power provider attributes may be updated in real time, and the charging scheduler may update the charging schedule based on changes to power provider attributes.

Abstract: A first request is received from a first processing node to produce data blocks of a first data stream representing a first communication topic. The first processing node is one of the processing nodes handling a specific function. Each of the processing nodes is executed within a specific node container having a specific operating environment. A global memory segment is allocated from a global memory to store the data blocks of the first data stream. A first local memory segment is mapped to the global memory segment. The first local memory segment is allocated from a first local memory of a first node container containing the first processing node. The first processing node directly accesses the data blocks of the first data stream stored in the global memory segment by accessing the mapped first local memory segment within the first node container.

Abstract: A device includes a microprocessor and a computer readable medium coupled to the microprocessor. The computer readable medium includes instructions stored thereon that cause the microprocessor to receive output from at least one sensor monitoring a travel context of a vehicle and determine, based on the output received, a condition of the vehicle. The instructions cause the microprocessor to determine, based on the determined condition of the vehicle, modified driving operations to improve the operation of the vehicle. The instructions cause the microprocessor to construct a message describing the determined modified driving operations and communicate one or more modified driving operations to an operator for potential implementation.

Abstract: A device includes a microprocessor and a computer readable medium coupled to the microprocessor. The computer readable medium includes instructions stored thereon that cause the microprocessor to receive output from at least one sensor monitoring a travel context of a vehicle and determine, based on the output received, a condition of the vehicle. The instructions cause the microprocessor to determine, based on the determined condition of the vehicle, modified driving operations to improve the operation of the vehicle. The instructions cause the microprocessor to construct a message describing the determined modified driving operations and communicate one or more modified driving operations to an operator for potential implementation.

Abstract: A cloud server maintains a neighboring vehicle data structure storing vehicle information of vehicles coupled to the cloud server over a network. The server receives a first request from a first of the vehicles, including a first vehicle identifier (ID) and current vehicle metadata of the first vehicle. In response to the first request, the server traverses the neighboring vehicle data structure to update a first node corresponding to the first vehicle based on the first vehicle ID and the current vehicle information of the first vehicle. The server transmits to the first vehicle over the network a list of one or more vehicle IDs identifying one or more vehicles that are within a predetermined geographic proximity of the first autonomous vehicles to allow the first vehicle to directly communicate with any vehicle in the list via a wireless local area network.

Abstract: According to one embodiment, a master storage node receives a search query for searching images from a client, where the master storage node is coupled to a number of worker storage nodes over a storage network. The master storage node performs a hash operation on one or more keywords of the search query using a first predetermined hash function, generating a first hash value. A first of the worker storage nodes is identified based on the first hash value. The master storage node redirects the search query to the first worker storage node to allow the first worker storage node service the search query. The first worker storage node is to identify one or more images from a first system memory of the first worker storage node based on the search query and to transmit the one or more images to the client.

Abstract: In one embodiment, an image analysis is performed on an image captured using a camera mounted on an autonomous vehicle, the image representing an exterior environment of an autonomous vehicle. Localization information surrounding the autonomous vehicle is obtained at a point in time. A perception of an audience external to the autonomous vehicle is determined based on the image analysis and the localization information. One or more content items are received from one or more content servers over a network in response to the perception of the audience. A first content item selected from the one or more content items is displayed on a display device mounted on an exterior surface of the autonomous vehicle.

Abstract: A magnetic tape device or system can store erasure encoded data that generates a multi-dimensional erasure code corresponding to an erasure encoded object comprising a code-word (CW). The multi-dimensional erasure code enables using a single magnetic tape in response to a random object/file request, and correct for an error within the single magnetic tape without using other tapes. Encoding logic can further utilize other magnetic tapes to generate additional parity tapes that recover data from an error of the single magnetic tape in response to the error satisfying a threshold severity for a reconstruction of the erasure coded object or chunk(s) of the CW. The encoding logic can be controlled, at least in part, by one or more iterative coding processes between multiple erasure code dimensions that are orthogonal to one another.