Abstract: The present invention pertains to the nanoencapsulation of siRNA and other biologics in phospholipid nanosomes for the improved delivery of siRNA and other biologics to targeted diseased human or animal organs and human or animal cells and apparatus and methods for making the same. In embodiments of the present invention, novel siRNAs were designed to down regulate CCR5 and CD4, based on an analysis of all known alternative transcripts for each gene from both human and monkey (Macaca mulatta) genomes. Embodiments of the present invention feature supercritical, critical and near critical fluids. Embodiments of the present invention also pertain to down regulation of CXCR4 receptor and targeting of nanosomes containing specific siRNA sequences to cells expressing those receptors on the cell surface by coating them with specific ligands. These include ligands for the receptors CCR5, CD4 and CXCR4.

Abstract: In one aspect the invention provides a boat support frame loading and unloading apparatus configured to draw a boat on to and off a boat support frame. This boat support frame has a loading end and a terminal end opposite to the loading end. The apparatus provided includes at least one roller assembly mounted to the support frame adjacent to the loading end of the support frame, said at least one roller assembly incorporating at least one roller element. The apparatus also includes at least one drive mechanism configured to rotate one or more roller elements to draw a boat onto and off the support frame through the loading end of the support frame. The roller assembly also includes a hull contact surface formed by a flexible belt which has a circumference greater than the circumference of the said at least one roller element incorporated into the roller assembly.

Abstract: In one aspect the invention provides a boat support frame loading and unloading apparatus configured to draw a boat on to and off a boat support frame. This boat support frame has a loading end and a terminal end opposite to the loading end. The apparatus provided includes at least one roller assembly mounted to the support frame adjacent to the loading end of the support frame, said at least one roller assembly incorporating at least one roller element. The apparatus also includes at least one drive mechanism configured to rotate one or more roller elements to draw a boat onto and off the support frame through the loading end of the support frame. The roller assembly also includes a hull contact surface formed by a flexible belt which has a circumference greater than the circumference of the said at least one roller element incorporated into the roller assembly.

Abstract: In one aspect the invention provides a boat support frame loading and unloading apparatus configured to draw a boat on to and off a boat support frame. This boat support frame has a loading end and a terminal end opposite to the loading end. The apparatus provided includes at least one roller assembly mounted to the support frame adjacent to the loading end of the support frame, said at least one roller assembly incorporating at least one roller element. The apparatus also includes at least one drive mechanism configured to rotate one or more roller elements to draw a boat onto and off the support frame through the loading end of the support frame. The roller assembly also includes a hull contact surface formed by a flexible belt which has a circumference greater than the circumference of the said at least one roller element incorporated into the roller assembly.

Abstract: In one aspect the invention provides a boat support frame loading and unloading apparatus configured to draw a boat on to and off a boat support frame. This boat support frame has a loading end and a terminal end opposite to the loading end. The apparatus provided includes at least one roller assembly mounted to the support frame adjacent to the loading end of the support frame, said at least one roller assembly incorporating at least one roller element. The apparatus also includes at least one drive mechanism configured to rotate one or more roller elements to draw a boat onto and off the support frame through the loading end of the support frame. The roller assembly also includes a hull contact surface formed by a flexible belt which has a circumference greater than the circumference of the said at least one roller element incorporated into the roller assembly.

Abstract: An osteogenic implant with improved osteointegration properties, this implant being made of titanium metal or a titanium-based alloy and being suitable for implantation in bones, said implant having a roughened surface, which in the hydroxylated state has been at least partially covered with a compound which comprises in the molecule at least two groups which are, independently of one another, a primary amino group, a secondary amino group, a carboxyl group, an amide group, a phosphano group and/or hydroxyl, or with a mixture of such compounds.

Abstract: The cache keeps regularly accessed disk I/O data within RAM that forms part of a computer systems main memory. The cache operates across a network of computers systems, maintaining cache coherency for the disk I/O devices that are shared by the multiple computer systems within that network. Read access for disk I/O data that is contained within the RAM is returned much faster than would occur if the disk I/O device was accessed directly. The data is held in one of three areas of the RAM for the cache, dependent on the size of the I/O access. The total RAM containing the three areas for the cache does not occupy a fixed amount of a computers main memory. The RAM for the cache grows to contain more disk I/O data on demand and shrinks when more of the main memory is required by the computer system for other uses.

Abstract: The cache keeps regularly accessed disk I/O data within RAM that forms part of a computer systems main memory. The cache operates across a network of computers systems, maintaining cache coherency for the disk I/O devices that are shared by the multiple computer systems within that network. Read access for disk I/O data that is contained within the RAM is returned much faster than would occur if the disk I/O device was accessed directly. The data is held in one of three areas of the RAM for the cache, dependent on the size of the I/O access. The total RAM containing the three areas for the cache does not occupy a fixed amount of a computers main memory. The RAM for the cache grows to contain more disk I/O data on demand and shrinks when more of the main memory is required by the computer system for other uses.

Abstract: An osteogenic implant with improved osteointegration properties, this implant being made of titanium metal or a titanium-based alloy and being suitable for implantation in bones, said implant having a roughened surface, which in the hydroxylated state has been at least partially covered with a compound which comprises in the molecule at least two groups which are, independently of one another, a primary amino group, a secondary amino group, a carboxyl group, an amide group, a phosphano group and/or hydroxyl, or with a mixture of such compounds.

Abstract: The proposal is for a holding element (100) which can be screwed into the internally threaded bore (14) of the implant (1) even during production of the latter and can thus be used to grip or hold the implant for the following production phases. Furthermore, the holding element (100) serves to fix an implant (1), which is screwed thereto, inside an ampoule (200) and for the application of a screwing-in tool for implantation. The particular feature of the ampoule (200) lies in the fact that it has a large-area, lateral cutout (231) in the casing and also a fixing part (210) for accommodating the holding element (100) in a clamped manner. The implant (1) can thus be pulled laterally out of the ampoule (200). The devices facilitate handling of the implant (1) during production and insertion into the bone.

Abstract: The specification teaches a system for collecting heat energy from solar radiation to heat a liquid medium. The system includes a solar radiation collector plate which has its rear face adapted to cause a liquid medium to be in direct thermal contact with the rear face of the plate while flowing over and covering essentially all of the rear face. According to one important aspect of the invention, the rear face is provided with a material having capillary attraction properties to spread a liquid medium across essentially all of the rear face of the plate so that the liquid medium absorbs large amounts of heat energy from the collector plate.