Abstract: Disclosed herein are heterocyclic compounds, for example, according to the following formula and analogs thereof: that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.

Abstract: A stent coupler for use with a medical device delivery system is disclosed. A stent delivery system includes a core member having a distal segment and a coupler positioned about the core member distal segment. The coupler is rotatably coupled to the core member and includes a rigid plate having a first end surface, a second end surface, and a side surface extending between the first and second end surfaces, the side surface comprising one or more projections separated by recesses. The delivery system further includes a stent extending along the core member distal segment such that an inner surface of the stent is engaged by the one or more projections of the engagement member.

Abstract: A vehicle attachment for guiding a vehicle includes a magnetic tape sensor, at least one sensor, a controller, at least one coupling device for attachment to the vehicle, and a vehicle interface system. The magnetic tape sensor is configured to detect a path. The at least one sensor can detect whether there are any obstructions along the path. The controller is configured to steer the vehicle along the predefined path and to adjust the speed of the vehicle to avoid coming in contact with any obstructions. The vehicle interface system is configured to communicatively couple the controller to at least one electronic control unit of the vehicle.

Abstract: A stent coupler for use with a medical device delivery system is disclosed. A stent delivery system includes a core member having a distal segment and a coupler positioned about the core member distal segment. The coupler is rotatably coupled to the core member and includes a rigid plate having a first end surface, a second end surface, and a side surface extending between the first and second end surfaces, the side surface comprising one or more projections separated by recesses. The delivery system further includes a stent extending along the core member distal segment such that an inner surface of the stent is engaged by the one or more projections of the engagement member.

Abstract: A stent coupler for use with a medical device delivery system is disclosed. A stent delivery system includes a core member having a distal segment and a coupler positioned about the core member distal segment. the coupler is rotatably coupled to the core member and includes a rigid plate having a first end surface, a second end surface, and a side surface extending between the first and second end surfaces, the side surface comprising one or more projections separated by recesses. The delivery system further includes a stent extending along the core member distal segment such that an inner surface of the stent is engaged by the one or more projections of the engagement member.

Abstract: A vehicle attachment for guiding a vehicle includes a magnetic tape sensor, at least one sensor, a controller, at least one coupling device for attachment to the vehicle, and a vehicle interface system. The magnetic tape sensor is configured to detect a path. The at least one sensor can detect whether there are any obstructions along the path. The controller is configured to steer the vehicle along the predefined path and to adjust the speed of the vehicle to avoid coming in contact with any obstructions. The vehicle interface system is configured to communicatively couple the controller to at least one electronic control unit of the vehicle.

Abstract: A two-part topical composition includes a first composition including a S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to be mixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.

Abstract: A stent coupler for use with a medical device delivery system is disclosed. A stent delivery system includes a core member having a distal segment and a coupler positioned about the core member distal segment. the coupler is rotatably coupled to the core member and includes a rigid plate having a first end surface, a second end surface, and a side surface extending between the first and second end surfaces, the side surface comprising one or more projections separated by recesses. The delivery system further includes a stent extending along the core member distal segment such that an inner surface of the stent is engaged by the one or more projections of the engagement member.

Abstract: A stent coupler for use with a medical device delivery system is disclosed. A stent delivery system includes a core member having a distal segment and a coupler positioned about the core member distal segment. the coupler is rotatably coupled to the core member and includes a rigid plate having a first end surface, a second end surface, and a side surface extending between the first and second end surfaces, the side surface comprising one or more projections separated by recesses. The delivery system further includes a stent extending along the core member distal segment such that an inner surface of the stent is engaged by the one or more projections of the engagement member.

Abstract: A stent coupler for use with a medical device delivery system is disclosed. A stent delivery system includes a core member having a distal segment and a coupler positioned about the core member distal segment. the coupler is rotatably coupled to the core member and includes a rigid plate having a first end surface, a second end surface, and a side surface extending between the first and second end surfaces, the side surface comprising one or more projections separated by recesses. The delivery system further includes a stent extending along the core member distal segment such that an inner surface of the stent is engaged by the one or more projections of the engagement member.