Abstract: The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

Abstract: Computer-implemented methods for an adaptive, personalized system for managing training compliance. Aspects include receiving behavior data associated with a user of a training compliance management system. Aspects further include updating a personalized predictive behavior model associated with the user using the behavior data. Aspects also include generating, using the personalized predictive behavior model, a training duration, a reminder type, and a reminder time for the user. Aspects include generating sub-units of a training unit that each have a completion time within a threshold of the training duration for the user. Aspects further include generating a reminder based on the reminder type comprising an uncompleted sub-unit of the sub-units of the training unit. Aspects include transmitting the reminder to the user at the reminder time.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

Abstract: A process for the segregation, sterilization, and purification of recycled plastic medical waste with the subsequent production of plastic products made therefrom is disclosed. Also disclosed is a method for the front-end segregation of recycled plastic medical waste into a polypropylene waste stream and a mixed plastic waste stream. These segregated streams are further purified through a processing method that removes contaminating fibrous, metal and other waste products. Polypropylene and mixed plastic streams isolated using these methods yield a homogenous material that can be blended with other materials for the production of raw plastic or for extrusion to form commercial plastic products. A method for tracking regulated and non-regulated medical waste stream production kinetics and chain of custody from discrete waste disposal sites is also disclosed.

Abstract: A method, computer system, and a computer program product for automatic detection of the need for a breakout virtual meeting is provided. The present invention may include receiving a computerized version of a real-time conversation between a plurality of participants of a virtual meeting. The present invention may also include determining whether a breakout virtual meeting is necessary among a subset of the plurality of participants of the virtual meeting. The present invention may further include, in response to determining that the breakout virtual meeting is necessary, automatically transmitting an alert indicating that the breakout virtual meeting is necessary among the subset of the plurality of participants of the virtual meeting.

Abstract: A process for the segregation, sterilization, and purification of recycled plastic medical waste with the subsequent production of plastic products made therefrom is disclosed. Also disclosed is a method for the front-end segregation of recycled plastic medical waste into a polypropylene waste stream and a mixed plastic waste stream. These segregated streams are further purified through a processing method that removes contaminating fibrous, metal and other waste products. Polypropylene and mixed plastic streams isolated using these methods yield a homogenous material that can be blended with other materials for the production of raw plastic or for extrusion to form commercial plastic products. A method for tracking regulated and non-regulated medical waste stream production kinetics and chain of custody from discrete waste disposal sites is also disclosed.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. Anew assay for identifying compounds with this mechanism of action is also disclosed.

Abstract: A new, stable trimeric TNF? structure is disclosed with distorted symmetry which can bind to the TNFR1 receptor to attenuate signalling therefrom, which can be used in the treatment and/or prevention of diseases associated with the soluble TNF?/TNFR1 interaction. Membrane-bound TNF? is not affected in its ability to signal through TNFR2, and thus the new structure of TNF? may be used in therapies which do not significantly raise the risk of infection or malignancy.

Abstract: A process for the segregation, sterilization, and purification of recycled plastic medical waste with the subsequent production of plastic products made therefrom is disclosed. Also disclosed is a method for the front-end segregation of recycled plastic medical waste into a polypropylene waste stream and a mixed plastic waste stream. These segregated streams are further purified through a processing method that removes contaminating fibrous, metal and other waste products. Polypropylene and mixed plastic streams isolated using these methods yield a homogenous material that can be blended with other materials for the production of raw plastic or for extrusion to form commercial plastic products. A method for tracking regulated and non-regulated medical waste stream production kinetics and chain of custody from discrete waste disposal sites is also disclosed.

Abstract: In an approach to generating interview questions, a computer retrieves a description of a job. A computer extracts one or more job requirements from the description. A computer retrieves information associated with a candidate for the job. A computer extracts an experience from the information relevant to the job. A computer identifies a first set of one or more topics associated with the one or more job requirements and a second set of one or more topics associated with the experience resulting from a first semantic search of a corpus. A computer identifies a match between at least one topic of the first set of one or more topics associated with the one or more job requirements and at least one topic of the second set of one or more topics associated with the experience. A computer generates one or more interview questions based on the match.

Abstract: A method, computer system, and a computer program product for discussion relevance feedback associated with an electronic meeting is provided. The method may include determining a meeting topic associated with the electronic meeting and receiving audio data recording the vocal interactions of one or more meeting attendees. The method may further include generating a textual representation of the received audio data and then identifying a current discussion topic based on the generated textual representation. The method may further include determining a semantic distance between the identified current discussion topic and the determined meeting topic and generating discussion relevance feedback based on the determined semantic distance.

Abstract: A method, computer system, and a computer program product for automatic detection of the need for a breakout virtual meeting is provided. The present invention may include receiving a computerized version of a real-time conversation between a plurality of participants of a virtual meeting. The present invention may also include determining whether a breakout virtual meeting is necessary among a subset of the plurality of participants of the virtual meeting. The present invention may further include, in response to determining that the breakout virtual meeting is necessary, automatically transmitting an alert indicating that the breakout virtual meeting is necessary among the subset of the plurality of participants of the virtual meeting.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. A new assay for identifying compounds with this mechanism of action is also disclosed.

Abstract: A method, computer system, and a computer program product for discussion relevance feedback associated with an electronic meeting is provided. The method may include determining a meeting topic associated with the electronic meeting and receiving audio data recording the vocal interactions of one or more meeting attendees. The method may further include generating a textual representation of the received audio data and then identifying a current discussion topic based on the generated textual representation. The method may further include determining a semantic distance between the identified current discussion topic and the determined meeting topic and generating discussion relevance feedback based on the determined semantic distance.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

Abstract: A process for the segregation, sterilization, and purification of recycled plastic medical waste with the subsequent production of plastic products made therefrom is disclosed. Also disclosed is a method for the front-end segregation of recycled plastic medical waste into a polypropylene waste stream and a mixed plastic waste stream. These segregated streams are further purified through a processing method that removes contaminating fibrous, metal and other waste products. Polypropylene and mixed plastic streams isolated using these methods yield a homogenous material that can be blended with other materials for the production of raw plastic or for extrusion to form commercial plastic products. A method for tracking regulated and non-regulated medical waste stream production kinetics and chain of custody from discrete waste disposal sites is also disclosed.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

Abstract: The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.