Abstract: The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: A lick deterrent device to deter animals from biting or chewing. The deterrent device has a flexible substrate physically conformable in three directions with conductive traces thereon. The lick deterrent device is configured for electrical connection to a removable power source. The traces are configured so that they may be contacted by an animal's tongue or saliva, so that upon contact, an electrical circuit is completed thereby delivering a mild electric shock to the animal. The lick deterrent device may be stretchable in at least one direction.

Abstract: A self-supporting, pleated filter, and method of making the same. The method includes forming a plurality of pleats in a filter media that extend along a front face and a rear face. The pleats include a plurality of pleat tips and sloping side surfaces generally perpendicular to the direction of pleating. At least one planar reinforcing strip oriented in the direction of pleating is bonded to the pleat tips on the front face. At least one reinforcing member is positioned along the rear face of the filter media. The filter media is then cut to size. Frame members are applied for some applications. The reinforcing member may be a reinforcing strip oriented in the direction of pleating and bonded to The rear face of the filter media prior to the step of forming the plurality of pleats. A second planar reinforcing strip may optionally be bonded to the reinforcing strip pleat tips. The reinforcing member, the first reinforcing strip and the second reinforcing strip can be aligned to form a truss structure.

Abstract: A tape application apparatus is adapted for both left-handed and right-handed use when applying tape from a roll to a first surface. An edge of the first surface is common to an edge of an adjacent second surface. The tape application apparatus includes a housing and a tape hub attached to the housing that is capable of slidably receiving the roll. The housing has first and second exterior surfaces and first and second interior surfaces and is capable of receiving the roll. When the tape application apparatus is guided in a first direction, the roll is moveable to a first dispensing position against the first interior side surface, and when the tape application apparatus is guided in a second direction opposite the first direction, the roll is moveable to a second dispensing position against the second interior side surface.

Abstract: A resilient hand-held abrasive article suitable, for example, for woodworking, includes a plurality of separated raised abrasive surfaces to allow the article to more effectively conform to a contoured surface. A method of making such an abrasive article is also disclosed.

Abstract: A laminate from which decorative films can be precisely applied to a substrate. The laminate includes a polymeric cover sheet having opposite outer and inner major surfaces. A layer of structured pressure sensitive adhesive is adhered to the inner major surface of the cover sheet. The structured pressure sensitive adhesive has a plurality of spaced passageways extending to at least one edge of the layer of structured pressure sensitive adhesive. A decorative film is adhered to the structured pressure sensitive adhesive. A second layer of pressure sensitive adhesive is adhered to the major surfaces of the decorative film opposite the layer of structured pressure sensitive adhesive. A release liner extends substantially across the second layer of pressure sensitive adhesive and a portion of the structured pressure sensitive adhesive.

Abstract: A self-supporting, pleated filter, and method of making the same. The method includes forming a plurality of pleats in a filter media that extend along a front face and a rear face. The pleats include a plurality of pleat tips and sloping side surfaces generally perpendicular to the direction of pleating. At least one planar reinforcing strip oriented in the direction of pleating is bonded to the pleat tips on the front face. At least one reinforcing member is positioned along the rear face of the filter media. The filter media is then cut to size. Frame members are applied for some applications. The reinforcing member may be a reinforcing strip oriented in the direction of pleating and bonded to the rear face of the filter media prior to the step of forming the plurality of pleats. A second planar reinforcing strip may optionally be bonded to the reinforcing strip pleat tips. The reinforcing member, the first reinforcing strip and the second reinforcing strip can be aligned to form a truss structure.

Abstract: A device for applying tape from a roll of tape (e.g., masking tape) along a surface to be protected with an edge of the tape extending along a juncture between the surface to be protected and a surface to be treated disposed at about a right angle with respect to the surface to be protected. The device includes a two portion housing around and journaling the tape roll, each portion having a tape contacting part of its inner surface in a first plane, and having in a second plane a guide part of its outer surface adapted to be slid along the surface to be treated. The first and second planes on each of the housing portions can be parallel or at a small angle with respect to each other so that they intersect along an application side of the housing. A pressure application structure is mounted on the housing with an outer edge each end of the pressure application structure at the intersection (if they intersect) of the first and second planes for a different adjacent one of the housing portions.

Abstract: A method of applying a tensile or compressive force to a selected location of a work piece or surface without damaging the work piece or the surface and without leaving adhesive residue thereon includes providing a device including a body member and a force applying member movably connected with the body member, attaching the body member and/or the force applying member to the work piece and/or surface using a double-sided stretch releasing adhesive such that one end of the force applying member is adjacent the selected location, and moving the force applying member toward the work piece or surface to generate a compressive force, or moving the force applying member away from the work piece or surface to generate a tensile force.

Abstract: A lever device includes an elongated body and a double-sided stretch releasing adhesive attached to the body, whereby the body can be firmly adhesively bonded to a surface and cleanly removed from the surface without damaging the surface by stretching the adhesive. The device may include a base, a body member pivotally connected with the base, and stretch releasing adhesive arranged to attach the base and/or body member to a surface or object. The base may be pivotally connected with an end of the body member or to the middle of the body member.