Patents by Inventor James Pollard
James Pollard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230416813Abstract: This disclosure provides a biochip comprising a plurality of wells. The biochip includes a membrane that is disposed in or adjacent to an individual well of the plurality of wells. The membrane comprises a nanopore, and the individual well comprises an electrode that detects a signal upon ionic flow through the pore in response to a species passing through or adjacent to the nanopore. The electrode can be a non-sacrificial electrode. A lipid bilayer can be formed over the plurality of wells using a bubble.Type: ApplicationFiled: June 19, 2023Publication date: December 28, 2023Applicant: Roche Sequencing Solutions, Inc.Inventors: Randall W. Davis, Edward Shian Liu, Eric Takeshi Harada, Anne Aguirre, Andrew Trans, James Pollard, Cynthia Cech
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Publication number: 20230412391Abstract: Various embodiments relate to a digital control unit of a bioprocess arrangement for controlling a bioprocess, wherein the digital control unit comprises a local data storage and a local processor unit, wherein the digital control unit comprises a bioprocess interface for sending and receiving bioprocess control data, wherein the digital control unit is configured to execute a bioprocess control routine via the local processor unit to control the bioprocess, wherein in the bioprocess control routine, the digital control unit generates bioprocess data from the actuator data and/or the sensor data and/or the user control command data. It is proposed that the digital control unit is configured to execute a signing routine via the local processor unit and that in the signing routine, the digital control unit digitally signs documentation data, derived from the bioprocess data, by generating a digital signature.Type: ApplicationFiled: September 16, 2021Publication date: December 21, 2023Inventors: Robert Soeldner, Jonas Austerjost, David James Pollard
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Publication number: 20230370281Abstract: A method for conducting a bioprocess with a digital control unit of a bioprocess arrangement, wherein the digital control unit comprises a local data storage and a local processor unit, wherein bioprocess data are generated by the digital control unit. It is proposed, that in a data safety routine, a documentation routine and a signing routine are executed, that in the documentation routine, documentation data are generated from the bioprocess data and that in the signing routine, a cryptographic private key is extracted from private key data and the documentation data are digitally signed with the cryptographic private key by generating a digital signature and that the documentation routine is executed continuously during the bioprocess and that the signing routine is executed discontinuously during the bioprocess in several signing cycles according to a signing strategy, which defines trigger events for initiating the signing routine.Type: ApplicationFiled: September 16, 2021Publication date: November 16, 2023Inventors: Robert Soeldner, Jonas Austerjost, David James Pollard
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Publication number: 20230370475Abstract: A method for conducting a bioprocess with a digital control unit of a bioprocess arrangement, wherein the digital control unit comprises a local data storage and a local processor unit, wherein the digital control unit comprises a bioprocess interface for sending and receiving bioprocess control data, wherein bioprocess data are generated by the digital control unit, wherein a bioprocess control routine is executed by the local processor unit to control the bioprocess, wherein in the bioprocess control routine, the bioprocess data are generated by the digital control unit from actuator data and/or sensor data and/or user control command data. It is proposed that a signing routine is initiated by the local processor unit in the data safety routine to be executed by an external signing unit(s).Type: ApplicationFiled: September 16, 2021Publication date: November 16, 2023Inventors: Robert Soeldner, Jonas Austerjost, David James Pollard
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Publication number: 20230357698Abstract: A computer implemented method for detecting foam on the surface of a liquid medium contained in a vessel is described. The method including the steps of receiving a sample image of at least a portion of the vessel comprising the liquid-gas interface and classifying the sample image between a first class and at least one second class, associated with different amounts of foam on the surface of the liquid. The classifying is performed by a deep neural network classifier that has been trained using a plurality of training images of at least a portion of a vessel comprising a liquid-gas interface. The plurality of training images may comprise at least some images that differ from each other by one or more of: the location of the liquid-gas interface on the image, the polar and/or azimuthal angle at which the liquid-gas interface is viewed on the image, and the light intensity or colour temperature of the one or more light sources that illuminated the imaged portion of the vessel when the image was acquired.Type: ApplicationFiled: August 13, 2021Publication date: November 9, 2023Inventors: Jonas Austerjost, Jens Matuszczyk, Robert Soeldner, Rickard Sjoegren, Christoffer Edlund, David James Pollard
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Patent number: 11725236Abstract: This disclosure provides a biochip comprising a plurality of wells. The biochip includes a membrane that is disposed in or adjacent to an individual well of the plurality of wells. The membrane comprises a nanopore, and the individual well comprises an electrode that detects a signal upon ionic flow through the pore in response to a species passing through or adjacent to the nanopore. The electrode can be a non-sacrificial electrode. A lipid bilayer can be formed over the plurality of wells using a bubble.Type: GrantFiled: April 27, 2021Date of Patent: August 15, 2023Inventors: Randall W. Davis, Edward Shian Liu, Eric Takeshi Harada, Anne Aguirre, Andrew Trans, James Pollard, Cynthia Cech
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Publication number: 20220372425Abstract: A system for an automated production of high cell density seed culture, HCDC, preparations, for cryo-preservation comprising a cell expansion device for growing a HCDC in a medium inside a device volume of the cell expansion device, at least one sensor for collecting data by at least temporally monitoring at least one parameter being indicative of the physiological state of the HCDC; and a control unit for processing the collected data to determine whether at least one predetermined criterion is fulfilled by the monitored parameter to control, based on whether the at least one predetermined criterion is fulfilled by the monitored parameter, at least a partial exchange of the medium by a cryo-protective agent, CPA.Type: ApplicationFiled: September 10, 2020Publication date: November 24, 2022Applicant: Sartorius Stedim Biotech GmbHInventors: Jens-Christoph Matuszczyk, David James Pollard, Johannes Lemke, Sebastian Ruhl
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Publication number: 20210324462Abstract: This disclosure provides a biochip comprising a plurality of wells. The biochip includes a membrane that is disposed in or adjacent to an individual well of the plurality of wells. The membrane comprises a nanopore, and the individual well comprises an electrode that detects a signal upon ionic flow through the pore in response to a species passing through or adjacent to the nanopore. The electrode can be a non-sacrificial electrode. A lipid bilayer can be formed over the plurality of wells using a bubble.Type: ApplicationFiled: April 27, 2021Publication date: October 21, 2021Applicant: Roche Sequencing Solutions, Inc.Inventors: Randall W. DAVIS, Edward Shian LIU, Eric Takeshi HARADA, Anne AGUIRRE, Andrew TRANS, James POLLARD, Cynthia CECH
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Patent number: 11021745Abstract: This disclosure provides a biochip comprising a plurality of wells. The biochip includes a membrane that is disposed in or adjacent to an individual well of the plurality of wells. The membrane comprises a nanopore, and the individual well comprises an electrode that detects a signal upon ionic flow through the pore in response to a species passing through or adjacent to the nanopore. The electrode can be a non-sacrificial electrode. A lipid bilayer can be formed over the plurality of wells using a bubble.Type: GrantFiled: February 11, 2019Date of Patent: June 1, 2021Assignee: Roche Sequencing Solutions, Inc.Inventors: Randall W. Davis, Edward Shian Liu, Eric Takeshi Harada, Anne Aguirre, Andrew Trans, James Pollard, Cynthia Cech
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Publication number: 20190185927Abstract: This disclosure provides a biochip comprising a plurality of wells. The biochip includes a membrane that is disposed in or adjacent to an individual well of the plurality of wells. The membrane comprises a nanopore, and the individual well comprises an electrode that detects a signal upon ionic flow through the pore in response to a species passing through or adjacent to the nanopore. The electrode can be a non-sacrificial electrode. A lipid bilayer can be formed over the plurality of wells using a bubble.Type: ApplicationFiled: February 11, 2019Publication date: June 20, 2019Applicant: Genia Technologies, Inc.Inventors: Randall W. DAVIS, Edward Shian LIU, Eric Takeshi HARADA, Anne AGUIRRE, Andrew TRANS, James POLLARD, Cynthia CECH
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Patent number: 10273536Abstract: A biochip for molecular detection and sensing is disclosed. The biochip includes a substrate. The biochip includes a plurality of discrete sites formed on the substrate having a density of greater than five hundred wells per square millimeter. Each discrete site includes sidewalls disposed on the substrate to form a well. Each discrete site includes an electrode disposed at the bottom of the well. In some embodiments, the wells are formed such that cross-talk between the wells is reduced. In some embodiments, the electrodes disposed at the bottom of the wells are organized into groups of electrodes, wherein each group of electrodes shares a common counter electrode. In some embodiments, the electrode disposed at the bottom of the well has a dedicated counter electrode. In some embodiments, surfaces of the sidewalls are silanized such that the surfaces facilitate the forming of a membrane in or adjacent to the well.Type: GrantFiled: March 10, 2016Date of Patent: April 30, 2019Assignees: GENIA TECHNOLOGIES, INC., ROCHE MOLECULAR SYSTEMS, INC.Inventors: Randall W. Davis, Edward Shian Liu, Eric Takeshi Harada, Anne Aguirre, Andrew Trans, James Pollard, Cynthia Cech, Hui Tian, Robert Yuan, John Foster, Roger Chen
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Patent number: 10246743Abstract: This disclosure provides a biochip comprising a plurality of wells. The biochip includes a membrane that is disposed in or adjacent to an individual well of the plurality of wells. The membrane comprises a nanopore, and the individual well comprises an electrode that detects a signal upon ionic flow through the pore in response to a species passing through or adjacent to the nanopore. The electrode can be a non-sacrificial electrode. A lipid bilayer can be formed over the plurality of wells using a bubble.Type: GrantFiled: December 20, 2016Date of Patent: April 2, 2019Assignee: GENIA TECHNOLOGIES, INC.Inventors: Randall W. Davis, Edward Shian Liu, Eric Takeshi Harada, Anne Aguirre, Andrew Trans, James Pollard, Cynthia Cech
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Patent number: 9909582Abstract: A pump is disclosed. The pump may include at least one pumping mechanism. The at least one pumping mechanism may include a barrel formed of a substrate having a bore and a plunger formed of a substrate and slidably disposed within the bore in the barrel. The pump may further include a coating disposed on the plunger. The coating may include a main layer containing a tribological material and a sacrificial break-in layer disposed on the main layer, the break-in layer containing a tribological material.Type: GrantFiled: January 30, 2015Date of Patent: March 6, 2018Assignee: Caterpillar Inc.Inventors: Robert Michael Campion, John Jay Truhan, Jr., Joshua Steffen, Shivangini Singh Hazari, Steven Charles Taylor, Michael James Pollard, Alan Ray Stockner
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Publication number: 20170198343Abstract: This disclosure provides a biochip comprising a plurality of wells. The biochip includes a membrane that is disposed in or adjacent to an individual well of the plurality of wells. The membrane comprises a nanopore, and the individual well comprises an electrode that detects a signal upon ionic flow through the pore in response to a species passing through or adjacent to the nanopore. The electrode can be a non-sacrificial electrode. A lipid bilayer can be formed over the plurality of wells using a bubble.Type: ApplicationFiled: December 20, 2016Publication date: July 13, 2017Inventors: Randall W. DAVIS, Edward Shian LIU, Eric Takeshi HARADA, Anne AGUIRRE, Andrew TRANS, James POLLARD, Cynthia CECH
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Patent number: 9567630Abstract: This disclosure provides a biochip comprising a plurality of wells. The biochip includes a membrane that is disposed in or adjacent to an individual well of the plurality of wells. The membrane comprises a nanopore, and the individual well comprises an electrode that detects a signal upon ionic flow through the pore in response to a species passing through or adjacent to the nanopore. The electrode can be a non-sacrificial electrode. A lipid bilayer can be formed over the plurality of wells using a bubble.Type: GrantFiled: October 22, 2014Date of Patent: February 14, 2017Assignee: Genia Technologies, Inc.Inventors: Randall W. Davis, Edward Shian Liu, Eric Takeshi Harada, Anne Aguirre, Andrew Trans, James Pollard, Cynthia Cech
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Publication number: 20160327507Abstract: A biochip for molecular detection and sensing is disclosed. The biochip includes a substrate. The biochip includes a plurality of discrete sites formed on the substrate having a density of greater than five hundred wells per square millimeter. Each discrete site includes sidewalls disposed on the substrate to form a well. Each discrete site includes an electrode disposed at the bottom of the well. In some embodiments, the wells are formed such that cross-talk between the wells is reduced. In some embodiments, the electrodes disposed at the bottom of the wells are organized into groups of electrodes, wherein each group of electrodes shares a common counter electrode. In some embodiments, the electrode disposed at the bottom of the well has a dedicated counter electrode. In some embodiments, surfaces of the sidewalls are silanized such that the surfaces facilitate the forming of a membrane in or adjacent to the well.Type: ApplicationFiled: March 10, 2016Publication date: November 10, 2016Inventors: Randall W. DAVIS, Edward Shian LIU, Eric Takeshi HARADA, Anne AGUIRRE, Andrew TRANS, James POLLARD, Cynthia CECH, Hui TIAN, Robert YUAN, John FOSTER, Roger CHEN
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Publication number: 20160222959Abstract: A pump is disclosed. The pump may include at least one pumping mechanism. The at least one pumping mechanism may include a barrel formed of a substrate having a bore and a plunger formed of a substrate and slidably disposed within the bore in the barrel. The pump may further include a coating disposed on the plunger. The coating may include a main layer containing a tribological material and a sacrificial break-in layer disposed on the main layer, the break-in layer containing a tribological material.Type: ApplicationFiled: January 30, 2015Publication date: August 4, 2016Applicant: Caterpillar Inc.Inventors: Robert Michael CAMPION, John Jay TRUHAN, JR., Joshua STEFFEN, Shivangini Singh HAZARI, Steven Charles TAYLOR, Michael James POLLARD, Alan Ray STOCKNER
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Patent number: 9322062Abstract: A biochip for molecular detection and sensing is disclosed. The biochip includes a substrate. The biochip includes a plurality of discrete sites formed on the substrate having a density of greater than five hundred wells per square millimeter. Each discrete site includes sidewalls disposed on the substrate to form a well. Each discrete site includes an electrode disposed at the bottom of the well. In some embodiments, the wells are formed such that cross-talk between the wells is reduced. In some embodiments, the electrodes disposed at the bottom of the wells are organized into groups of electrodes, wherein each group of electrodes shares a common counter electrode. In some embodiments, the electrode disposed at the bottom of the well has a dedicated counter electrode. In some embodiments, surfaces of the sidewalls are silanized such that the surfaces facilitate the forming of a membrane in or adjacent to the well.Type: GrantFiled: October 22, 2014Date of Patent: April 26, 2016Inventors: Randall W. Davis, Edward Shian Liu, Eric Takeshi Harada, Anne Aguirre, Andrew Trans, James Pollard, Cynthia Cech, Hui Tian, Robert Yuan, John Foster, Roger Chen
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Publication number: 20160097340Abstract: A cylinder liner assembly is disclosed for use with an engine. The cylinder liner assembly may have a liner with a hollow, generally cylindrical body extending from a top end to a bottom end along a longitudinal axis. The cylinder liner assembly may also have a seal disposed around the liner at the top end and an anti-polishing ring disposed within the top end of the liner. The anti-polishing ring may have an annular groove formed on an outer surface to provide an air gap between the anti-polishing ring and the liner. The annular groove may axially overlap at least a portion of the seal.Type: ApplicationFiled: October 3, 2014Publication date: April 7, 2016Applicant: CATERPILLAR INC.Inventors: Bradley L. Morgan, James A. Subatch, JR., Michael James Pollard
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Patent number: D981599Type: GrantFiled: September 20, 2021Date of Patent: March 21, 2023Inventor: James Pollard