Abstract: The present invention includes a method to detect IgE using a human Fc epsilon receptor (Fc?R) to detect IgE antibodies in a biological sample from a cat, a dog, or a horse. The present invention also relates to kits to perform such methods.

Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.

Abstract: A diagnostic device includes a housing, a connector, and a diagnostic unit. The connector is integrated with the housing and is electrically connected to a diagnostic port of a vehicle. A diagnostic electronic control unit is integrated with the housing and electrically communicates with the connector. The diagnostic electronic control unit receives and interprets a power line carrier (PLC) diagnostic message from a vehicle ECU.

Abstract: The invention relates to a bispecific molecule comprising a first recognition binding moeity that binds a Cab-like receptor cross-linked using a poly-(ethylene glycol) (“PEG”) linker with one or more second recognition binding moieties that bind a molecule. The invention also relates to methods of producing such bispecific molecules and to therapeutic uses of such bispecific molecules.

Abstract: The invention provides a method for producing purified compositions of bispecific molecules each comprising (a) an antigen recognition portion that binds a C3b-like receptor and (b) one or more double-stranded DNA molecules cross-linked to the antigen recognition portion. In particular, the invention provides a method for purifying bispecific molecules using alcohol precipitation. The invention also relates to the purified products of bispecific molecules. The purified compositions of the invention are useful for treating Systemic Lupus Erythematosus (SLE).

Abstract: The invention provides a bispecific molecule comprising an antibody that binds a C3b-like to one or more antigen-binding antibody fragments, each of which binds an antigenic molecule. The invention also provides methods of producing such bispecific molecules and to therapeutic uses of such bispecific molecules. The invention further provides bispecific molecules in which the antigen-binding antibody fragment binds the protective antigen protein of Bacillus anthracis (Anthrax) exotoxin for treatment of Anthrax infection.

Abstract: Resettable circuit interrupting devices, such as GFCI devices, that include reverse wiring protection, and optionally an independent trip portions and/or a reset lockout portion are provided. The reverse wiring protection operates at both the line and load sides of the device so that in the event line side wiring to the device is improperly connected to the load side, fault protection for the device remains. The trip portion operates independently of a circuit interrupting portion used to break the electrical continuity in one or more conductive paths in the device. The reset lockout portion prevents the reestablishing of electrical continuity in open conductive paths if the circuit interrupting portion is non-operational or if an open neutral condition exists.

Abstract: An intelligent occupancy sensor, such as a Passive InfraRed (PIR) sensor, with variable adaptive timeout. When a person first walks into the room and, after a very short time, walks out of the room, the occupancy sensor operates with a short timeout. When, however, a person lingers in the room, the occupancy sensor switches to another mode of operation where the timeout increases or decreases based on the frequency that the sensor detects motion in the room and the amplitude and/or duration of the signal of the detected motion.

Abstract: A lamp holder body having a lamp socket and a ground fault circuit interrupter (GFCI) receptacle on different surfaces of said body. The lamp holder body can be mounted to a standard outlet box and can have a provision to accommodate a switch or a lamp socket having a pull-chain switch.

Abstract: The present invention includes a method to detect IgE using a human Fc epsilon receptor (Fc?R) to detect IgE antibodies in a biological sample from a cat, a dog, or a horse. The present invention also relates to kits to perform such methods.

Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.

Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

Abstract: The present invention relates to antibiotic compounds and intermediates useful in their preparation. Many of the antibiotic compounds contain a substituted isoxazolidine ring. The invention also relates to pharmaceutical compositions containing a compound of the invention. The invention further provides processes for the preparation of compounds of the invention, and methods for their use as therapeutic agents.

Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

Abstract: A tire pressure monitoring system (12) for a vehicle (10) has a plurality of tires (14a, b, c and d) in respective rolling locations and a spare tire (14e) generating a spare tire identification. A controller (22) starts the timer (44) and sets a tire status to a rolling status, a pending rolling status, a spare status or a pending spare status in response to the timer and the vehicle speed. The controller (22) stores the status and the spare tire identification in the memory.

Abstract: A pressure monitoring system (12) for a tire (14a) of an automotive vehicle includes a first pressure sensor (94) coupled to the wheel, a pressure transmitter (90) coupled to the pressure sensor (94) whereby the transmitter generates a pressure signal. A controller (22) is coupled to the pressure transmitter. The controller (22) receives the pressure signal and in a first stage, compares the pressure signal to a pressure threshold to obtain a sensor status. In a second stage, the controller (22) qualifies the sensor status signal by generating a warning status in response to the sensor status.