Patents by Inventor James Proviano Burrows

James Proviano Burrows has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-Cryogenic, Ammonia-Free Reduction of Aryl Compounds
    Publication number: 20240092708
    Abstract: A method of reducing an aromatic ring or a cyclic, allylic ether in a compound includes preparing a reaction mixture including a compound including an aromatic moiety or a cyclic, allylic ether moiety, an alkali metal, and either ethylenediamine, diethylenetriamine, triethylenetetramine, or a combination thereof, in an ether solvent; and reacting the reaction mixture at from ?20° C. to 30° C. for a time sufficient to reduce a double bond in the aromatic moiety to a single bond or to reduce the cyclic, allylic ether moiety.
    Type: Application
    Filed: November 28, 2023
    Publication date: March 21, 2024
    Inventors: Kazunori Koide, James Proviano Burrows
  • Non-cryogenic, ammonia-free reduction of aryl compounds
    Patent number: 11866386
    Abstract: A method of reducing an aromatic ring or a cyclic, allylic ether in a compound includes preparing a reaction mixture including a compound including an aromatic moiety or a cyclic, allylic ether moiety, an alkali metal, and either ethylenediamine, diethylenetriamine, triethylenetetramine, or a combination thereof, in an ether solvent; and reacting the reaction mixture at from ?20° C. to 30° C. for a time sufficient to reduce a double bond in the aromatic moiety to a single bond or to reduce the cyclic, allylic ether moiety.
    Type: Grant
    Filed: September 17, 2021
    Date of Patent: January 9, 2024
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Kazunori Koide, James Proviano Burrows
  • Non-Cryogenic, Ammonia-Free Reduction of Aryl Compounds
    Publication number: 20220089508
    Abstract: A method of reducing an aromatic ring or a cyclic, allylic ether in a compound includes preparing a reaction mixture including a compound including an aromatic moiety or a cyclic, allylic ether moiety, an alkali metal, and either ethylenediamine, diethylenetriamine, triethylenetetramine, or a combination thereof, in an ether solvent; and reacting the reaction mixture at from ?20° C. to 30° C. for a time sufficient to reduce a double bond in the aromatic moiety to a single bond or to reduce the cyclic, allylic ether moiety.
    Type: Application
    Filed: September 17, 2021
    Publication date: March 24, 2022
    Inventors: Kazunori Koide, James Proviano Burrows
  • Analogs of 2-Pralidoxime as Antidotes Against Organophosphorus Nerve Agents
    Publication number: 20210317084
    Abstract: Provided herein are compounds useful in treating exposure to an organophosphorus compound, such as a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, such as sarin. Compositions, e.g. pharmaceutical compositions or dosage forms, comprising the compounds also are provided herein. Methods of treating a patient exposed to a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, e.g., an organophosphorus compound, such as sarin, also are provided.
    Type: Application
    Filed: May 30, 2019
    Publication date: October 14, 2021
    Inventors: Kazunori Koide, Kiflai Bein, George D. Leikauf, Robert Kruger Bressin, James Proviano Burrows, Adriana Gambino, Dianne Pham