Abstract: Highly accurate, self-calibrating data processors and methods for calibrating the same use internal analog references with negligible time and temperature drifts. A first input reference signal set generated by any accurate, precision analog reference is applied to a data processor. The corresponding output response is compared to the theoretical ideal output response to determine the data processor's initial gain and offset errors. This information can be stored in non-volatile memory, recalled, and used to compensate for the data processor's initial gain and offset errors during actual use of the data processor. Subsequent errors due to time and temperature drifting can be determined by comparing the output responses to a second input reference signal set which is generated by the internal analog reference. The subsequent errors can be combined with the initial errors to compensate for system errors within the data processor.