Patents by Inventor JAMES R. APGAR

JAMES R. APGAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF
    Publication number: 20230416405
    Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
    Type: Application
    Filed: March 13, 2023
    Publication date: December 28, 2023
    Inventors: Debra Pittman, James R. Apgar, Zong Sean Juo, Macy Jin, Mark Stahl, Gregory J. Carven, Matthew Holsti, Susan Benard, Sunita R. Hett, Reema Jasuja
  • Tissue factor pathway inhibitor antibodies and uses thereof
    Patent number: 11634504
    Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: April 25, 2023
    Assignee: Pfizer Inc.
    Inventors: Debra Pittman, James R. Apgar, Zong Sean Juo, Macy Jin, Mark Stahl, Gregory J. Carven, Matthew Holsti, Susan Benard, Sunita R. Hett, Reema Jasuja
  • Anti-GDF15 antibodies, compositions and methods of use
    Patent number: 11566066
    Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to GDF15, as well as methods and uses for the antibodies.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: January 31, 2023
    Assignee: Pfizer Inc.
    Inventors: Kevin Charles Beaumont, Danna M. Breen, Matthew Allister Lambert, Jeffrey Raymond Chabot, Tao He, Ksenya Shchors, James R. Apgar
  • ANTI-GDF15 ANTIBODIES, COMPOSITIONS AND METHODS OF USE
    Publication number: 20220380448
    Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to GDF15, as well as methods and uses for the antibodies.
    Type: Application
    Filed: August 1, 2022
    Publication date: December 1, 2022
    Inventors: Kevin Charles Beaumont, Danna M. Breen, Matthew Allister Lambert, Jeffrey Raymond Chabot, Tao He, Ksenya Shchors, James R. Apgar
  • TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF
    Publication number: 20210101998
    Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
    Type: Application
    Filed: November 24, 2020
    Publication date: April 8, 2021
    Inventors: Debra Pittman, James R. Apgar, Zong Sean Juo, Macy Jin, Mark Stahl, Gregory J. Carven, Matthew Holsti, Susan Benard, Sunita R. Hett, Reema Jasuja
  • Tissue factor pathway inhibitor antibodies and uses thereof
    Patent number: 10875929
    Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: December 29, 2020
    Assignee: Pfizer Inc.
    Inventors: Debra Pittman, James R. Apgar, Zong Sean Juo, Macy Jin, Mark Stahl, Gregory J. Carven, Matthew Holsti, Susan Benard, Sunita R. Hett, Reema Jasuja
  • ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR
    Publication number: 20200277365
    Abstract: The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.
    Type: Application
    Filed: November 13, 2019
    Publication date: September 3, 2020
    Inventors: MICHELLE M. MADER, JAMES R. APGAR, KEVIN D. PARRIS
  • TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF
    Publication number: 20200190214
    Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
    Type: Application
    Filed: December 17, 2019
    Publication date: June 18, 2020
    Inventors: Debra Pittman, James R. Apgar, Zong Sean Juo, Macy Jin, Mark Stahl, Gregory J. Carven, Matthew Holsti, Susan Benard, Sunita R. Hett, Reema Jasuja
  • ANTI-GDF15 ANTIBODIES, COMPOSITIONS AND METHODS OF USE
    Publication number: 20200055930
    Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to GDF15, as well as methods and uses for the antibodies.
    Type: Application
    Filed: August 15, 2019
    Publication date: February 20, 2020
    Inventors: Kevin Charles Beaumont, Danna M. Breen, Matthew Allister Lambert, Jeffrey Raymond Chabot, Tao He, Ksenya Shchors, James R. Apgar
  • Tissue factor pathway inhibitor antibodies and uses thereof
    Patent number: 10550200
    Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: February 4, 2020
    Assignee: Pfizer Inc.
    Inventors: Debra Pittman, James R. Apgar, Zong Sean Juo, Macy Jin, Mark Stahl, Gregory J. Carven, Matthew Holsti, Susan Benard, Sunita R. Hett, Reema Jasuja
  • ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR
    Publication number: 20180057579
    Abstract: The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.
    Type: Application
    Filed: August 1, 2017
    Publication date: March 1, 2018
    Inventors: MICHELLE M. MADER, JAMES R. APGAR, KEVIN D. PARRIS
  • Antagonist antibodies against GDF-8 and uses therefor
    Patent number: 9751937
    Abstract: The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: September 5, 2017
    Assignee: PFIZER INC.
    Inventors: Michelle M. Mader, James R. Apgar, Kevin D. Parris
  • TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF
    Publication number: 20170073428
    Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
    Type: Application
    Filed: August 17, 2016
    Publication date: March 16, 2017
    Inventors: Debra Pittman, James R. Apgar, Zong Sean Juo, Macy Jin, Mark Stahl, Gregory J. Carven, Matthew Holsti, Susan Benard, Sunita R. Hett, Reema Jasuja
  • ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR
    Publication number: 20150337032
    Abstract: The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.
    Type: Application
    Filed: February 19, 2015
    Publication date: November 26, 2015
    Inventors: MICHELLE M. MADER, JAMES R. APGAR, KEVIN D. PARRIS
  • Antagonist antibodies against GDF-8 and uses therefor
    Patent number: 8992913
    Abstract: The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.
    Type: Grant
    Filed: June 12, 2013
    Date of Patent: March 31, 2015
    Assignee: Pfizer Inc.
    Inventors: Michelle M. Mader, James R. Apgar, Kevin D. Parris
  • ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR
    Publication number: 20130336982
    Abstract: The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.
    Type: Application
    Filed: June 12, 2013
    Publication date: December 19, 2013
    Inventors: MICHELLE M. MADER, JAMES R. APGAR, KEVIN D. PARRIS