Patents by Inventor James R. Bunzow

James R. Bunzow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aqueous solution containing D.sub.1 dopamine receptor
    Patent number: 5547845
    Abstract: Cloned genes which code for the D.sub.1 dopamine receptor are disclosed. The receptors coded for by these clones bind dopamine ligands with the proper pharmacological profile and, when expressed in the cell membrane of a suitable host and so bound, stimulate adenylyl cyclase. Also disclosed are vectors comprising a cloned gene encoding a D.sub.1 -dopamine receptor, cells transformed with such vectors, and oligonucleotide probes capable of selectively hybridizing to DNA comprising a portion of a gene coding for a D.sub.1 -dopamine receptor. The cloned genes are useful for making proteins and cell membrane preparations which can be used to screen compounds for D.sub.1 -dopamine receptor binding activity, are useful in molecular biology, and are useful as diagnostic probes.
    Type: Grant
    Filed: February 15, 1994
    Date of Patent: August 20, 1996
    Assignees: Duke University, Oregon Health Sciences Univ.
    Inventors: James R. Bunzow, Olivier Civelli, David K. Grandy, Qun Y. Zhou
  • Human D4 dopamine receptor and its uses
    Patent number: 5516683
    Abstract: The present invention is directed toward the isolation, characterization and pharmacological use of the human D4 dopamine receptor. The nucleotide sequence of the gene corresponding to this receptor and alleleic variants thereof are provided by the invention. The invention particularly provides recombinant eukaryotic expression constructs capable of expressing the human D4 dopamine receptor at useful levels in cultures of transformed eukaryotic cells. The invention provides cultures of transformed eukaryotic cells which synthesize such useful amounts of human D4 dopamine receptor protein, and methods for characterizing novel psychotropic compounds using such cultures.
    Type: Grant
    Filed: April 29, 1993
    Date of Patent: May 14, 1996
    Assignee: State of Oregon, Acting by and Through the Oregon State Board of Higher Education on Behalf of the Oregon Health Sciences University a non-profit organization
    Inventors: David K. Grandy, James R. Bunzow, Olivier Civelli, Hubert H.-M. Van Tol
  • Cloned genes encoding the D.sub.1 dopamine receptor
    Patent number: 5389543
    Abstract: Cloned genes which code for the D.sub.1 dopamine receptor are disclosed. The receptors coded for by these clones bind dopamine ligands with the proper pharmacological profile and, when expressed in the cell membrane of a suitable host and so bound, stimulate adenylyl cyclase. Also disclosed are vectors comprising a cloned gene encoding a D.sub.1 -dopamine receptor, cells transformed with such vectors, and oligonucleotide probes capable of selectively hybridizing to DNA comprising a portion of a gene coding for a D.sub.1 -dopamine receptor. The cloned genes are useful for making proteins and cell membrane preparations which can be used to screen compounds for D.sub.1 -dopamine receptor binding activity, are useful in molecular biology, and are useful as diagnostic probes.
    Type: Grant
    Filed: July 2, 1992
    Date of Patent: February 14, 1995
    Assignees: Duke University, Oregon Health Sciences University
    Inventors: James R. Bunzow, Olivier Civelli, David K. Grandy, Qun Y. Zhou, Marc G. Caron, Allen Dearry, Pierre Falardeau, Jay A. Gingrich