Abstract: Methods are provided for treating or preventing human immunodeficiency virus-1 (HIV-1) or human immunodeficiency virus-2 (HIV-2) in a virologically suppressed patient in need thereof comprising switching the patient from an antiretroviral treatment regimen comprising at least three antiretroviral agents to a treatment regimen comprising only two antiretroviral agents. In one aspect the two treatment regimen consists of dolutegravir, rilpivirine and at least one pharmaceutically acceptable excipient, diluent or carrier. In another aspect of the invention, there is provided a multilayer tablet comprising dolutegravir or a pharmaceutically acceptable salt thereof and rilpivirine or a pharmaceutically acceptable salt thereof.

Abstract: A multi-functional tool that is particularly useful for in-field service and maintenance of a chainsaw, the tool having a handle section and a head section, wherein the handle section includes a plurality of tubular openings adapted to receive a multiplicity of repair tools, such as a chain file, depth gauge, screwdriver, wrench tool, etc., without requiring the removal of all other tools. The head section includes a pair of spaced-apart spikes to allow the tool to be secured to a wooden structure, such as a tree stump and a clamp to secure the chainsaw while service or maintenance is performed. The multi-functional chainsaw field maintenance tool further includes a device to facilitate transport of the multi-functional tool, such as a belt clip, shoulder strap or magnetic attachment device.

Abstract: In the present invention, the computer databases of “For Sale” listings of residential real estate properties aggregated by MLSs are retrieved electronically as frequently as daily from the MLSs and compared on a daily basis with the databases of residential property customer records uploaded by subscribers. To the extent that such comparisons identify matching residential properties from both databases, such matches are reported daily to mortgage brokers or lenders whose customer properties were matched. These reports enable the brokers or lenders to immediately contact a customer and offer that customer the best option for financing his new home.

Abstract: Wild-type bacteria with polyurethanase activity, and the ability to excrete polyurethanase into a culture medium have been genetically altered to significantly increase their polyurethanase activity. Biologically pure cultures of these genetically altered are cultured in a medium containing an inducer for the production of polyurethanase. The bacteria are then removed from the culture medium to provide a preparation with a high polyurethanase activity. One useful genetically altered bacteria is a strain of Pseudomonas chlororaphis designated ATTC No. 55729. The polyurethanase-containing preparation may then be used directly to degrade polyurethane, particularly polyurethane and polyurethane-based coatings.

Abstract: A gene coding for the expression of metallothionein is incorporated into an xpression vehicle for expressing the metallothionein gene into the periplasmic space of a bacterium including the expression vehicle. It may also be possible to incorporate multiple copies of the metallothionein gene within a single bacterium. One typical expression vehicle is a p-MalP plasmid constructed to include the metallothionein gene. Using this expression vehicle, one can induce bacteria, such as transformed E. coli, to express metallothionein into the periplasmic space as a fusion product with, for example, the maltose-binding protein. Killed cell that have expressed metallothionein into the periplasmic space may then be attached to a solid support. The resulting device may be used to remove heavy metals from aqueous media.

Abstract: Wild-type bacteria with polyurethanase activity, and the ability to excrete polyurethanase into a culture medium have been genetically altered to significantly increase their polyurethanase activity. Biologically pure cultures of these genetically altered are cultured in a medium containing an inducer for the production of polyurethanase. The bacteria are then removed from the culture medium to provide a preparation with a high polyurethanase activity. One useful genetically altered bacteria is a strain of Pseudomonas chlororaphis designated ATTC No. 55729. The polyurethanase-containing preparation may then be used directly to degrade polyurethane, particularly polyurethane and polyurethane-based coatings.

Abstract: A honeycomb seal construction which includes said seal and a mounting ring therefor, said seal having honeycomb cells and being in a press-fit relationship with said mounting ring, there being a brazed joint between the seal and said ring defined by brazing material deposited in said cells at the OD of said seal.

Abstract: Apparatus for installation of honeycomb core seals in jet engine mounting rings, including spray deposition of brazing alloy in seals and establishment of compressive relationships between seal and ring prior to brazing of seal in ring.

Abstract: Method and apparatus for installation of honeycomb core seals in jet engine mounting rings, including spray deposition of brazing alloy in seals and establishment of compressive relationships between seal and ring prior to brazing of seal in ring.

Abstract: Novel tetracyclic spirobenzazepine compounds of the formula ##STR1## or a pharmaceutically-acceptable salt, amide or ester thereof, which are dopamine D-1 receptor antagonists useful for treating dopamine-related neurological and psychological disorders, cognitive impairment, attention deficit disorders and addictive behavior disorders.

Abstract: Crop oil concentrates are disclosed which not only increase the herbicidal efficacy of herbicides from diverse chemical classes, but moreover assist in defeating the apparent antagonism which often arises when two or more herbicides are utilized together.

Abstract: Ready-to-Dilute (RTD) herbicide formulations containing crop oil type adjuvants are disclosed which may be added as is to water to form a tank mix for herbicide application. The formulations are storage stable for extended periods, provide for rapid self-emulsification, form a stable tank mix, and moreover provide equal or better herbicidal efficiency than tank mixes containing commercially available standard crop oils and standard herbicide formulations.

Abstract: Crop oil concentrates are disclosed which not only increase the herbicidal efficacy of herbicides from diverse chemical classes, but moreover assist in defeating the apparent antagonism which often arises when two or more herbicides are utilized together.

Abstract: A signaling arrangement where all terminal configuration data is stored in a switching system, but where each user terminal responds to a message from the system, defining one of the user terminal buttons as the selected call appearance at the terminal, by operating in a functional signaling mode to communicate with the system using functional messages concerning a call at the selected call appearance. Idle and ringing preference methods for use in terminating calls and auto-drop and auto-hold alternatives for use when moving from one call appearance to another are disclosed as well as methods for holding or dropping calls. Implicit and explicit conferencing methods are also disclosed.

Abstract: An elongated metallic strip is provided which has oppositely disposed convolutions constituted by sinuosities, corrugations, nodes, or the like, and said convolutions are constituted by nadir and zenith convolutions. Provided on the nadir and zenith convolutions are cooperative hinge and locating means assisting in the juxtaposition of said nadir and zenith convolutions to one another, said integral hinge means being provided thereon to facilitate the disposition of such strip into a helical configuration. A seal is provided which is created by helically winding the strip to locate edges thereof in a cylindrical sealing configuration by juxtaposing the convolutions of the strip in operative relationship with one another and welding said convolutions to one another.

Abstract: An apparatus for forming honeycomb-type core strip includes a source of metallic ribbon, form gears for forming a desired configuration in the ribbon and take-up means for taking up the core strip as it is issued from the form gears. Interposed between the source and take-up means is lubricating means for insuring adequate lubrication of the metallic ribbon as it enters the bite of the form gears. The form gears are characterized by a configuration which enables them to impart hinge means to the ribbon which facilitates the utilization of the ribbon in unitary metallic seal constructions wherein a continuous length of the ribbon is bent into helical form.

Abstract: An apparatus is provided for forming a circular, honeycomb-type engine seal from pre-formed core strip having male and female nodes. The apparatus includes a source of strip and means for forming the strip into a circular seal configuration wherein the male and female nodes of the strip are automatically juxtaposed to each other for weldment as relative movement between the forming means and the source occurs to withdraw additional strip from the core strip source. As the relative movement continues, the juxtaposed male and female nodes are exposed to welding head means of the apparatus which welds the male and female nodes to one another. The forming means includes means for causing said relative movement constituted by drive means which is adjustable to permit forming means of different sizes to be utilized. The movement of the forming means permits successive layers or laminae of the strip to be welded to each other in circular form until a seal of the desired dimension is achieved.

Abstract: Biological toxins are indirectly detected by using polymerase chain reaction to amplify unique nucleic acid sequences coding for the toxins or enzymes unique to toxin synthesis. Buffer, primers coding for the unique nucleic acid sequences and an amplifying enzyme are added to a sample suspected of containing the toxin. The mixture is then cycled thermally to exponentially amplify any of these unique nucleic acid sequences present in the sample. The amplified sequences can be detected by various means, including fluorescence. Detection of the amplified sequences is indicative of the presence of toxin in the original sample. By using more than one set of labeled primers, the method can be used to simultaneously detect several toxins in a sample.

Abstract: The fluorescent detection of target DNA is enhanced by amplifying the DNA in a sample by initiating a polymerase chain reaction using a first pair of primers and an appropriate polymerase. The DNA is then reamplified, this time using a second pair of nested primers which bracket DNA base sequences within the region bracketed by the first set of primers. At least one of the second pair of primers is bound to a fluorescent reporter molecule and at least one of the second pair of primers has bound thereto a specific binding site for a double-stranded DNA-binding protein. The thus amplified sample is then contacted with a fluorescent sensor having the appropriate double-stranded DNA-binding protein attached thereto. Then, the fluorescent reporter molecule is excited by light of the appropriate wavelength. The present invention provides greater sensitivity, adaptability and ease of use than previously available.