Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: A method and apparatus for eliminating vortex whistle noise in a radial-to-axial compressor intake uses a plurality of vortex-disturbing tabs mounted to the trailing edges of inlet guide vanes and extending into the flow path between adjacent vanes. The tabs are mounted to the guide vane so that the tab is always perpendicular to the guide vane, regardless of the vanes angular position.