Abstract: A heat exchanger plate has multiple structures thereon. A heat transfer portion has a plurality of ribs arranged in a rib pattern. A fluid ingress structure is arranged near a first corner of the heat exchanger plate. The structure includes a first open fluid aperture defined in the heat exchanger plate, and a first platform arranged between the first open fluid aperture and the first corner. The first platform is connected to a rib of the rib pattern. A fluid bypass structure is arranged near a second corner. The fluid bypass structure includes a closed fluid aperture defined in the heat exchanger plate, a second platform completely surrounding the closed fluid aperture, and a first corner rib arranged between the second platform and the second corner. The first corner rib is connected to a rib of the rib pattern.

Abstract: The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a sample, including using combinations of capture agents, each combination being unique to the splicing variant to be detected/measured.

Abstract: This invention relates to methods and apparatus for detecting the pattern of post translational modification in a protein or in a plurality of proteins in a sample. One or more target proteins are subjected to predetermined proteolysis to yield plural peptide fragments comprising potential post translational modification sites. The fragments and the state of such sites are analyzed to yield a post translational pattern for the protein or proteins.

Abstract: The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a sample, including using combinations of capture agents, each combination being unique to the splicing variant to be detected/measured.

Abstract: The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a sample, including using combinations of capture agents to identify the isoforms to be detected/measured.

Abstract: An activated carbon-metal oxide matrix is disclosed. The activated carbon-metal oxide matrix may be obtained by a method including the steps of: preoxidizing a carbon material, grinding the preoxidized carbon material; mixing the ground preoxidized material with a metal oxide to form a carbon mixture; extruding the carbon mixture; carbonizing and activating the extrudate. The activated carbon-metal oxide matrix may be used to remove odorous compounds, acidic gases, and volatile organic compounds from a gas.

Abstract: The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.

Abstract: A stratified bed of activated carbon having regions of functionalized and non-functionalized activated carbon can be utilized to remove contaminants from fluids such as groundwater. The functionalized region has activated carbon particles comprising a cationic or anionic compound that can remove organic or inorganic anionic or cationic compounds from the fluid to be treated. The non-functionalized region comprises powdered or granular activated carbon or adsorbent media downstream of the functionalized region and captures any leaching species or compounds from the functionalized region.

Abstract: The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.

Abstract: An activated carbon/metal oxide filter element is disclosed. The filter element may be prepared by blending an activated carbon, a metal oxide, and a binder to form a filter media mixture, shaping the filter media mixture into a filter body. The filter body may be calcined to form a filter element. The activated carbon/metal oxide filter element may be used to remove odorous compounds, acidic gases, and volatile organic compounds from a gas.

Abstract: An activated carbon/metal oxide filter element is disclosed. The filter element may be prepared by blending an activated carbon, a metal oxide, and a binder to form a filter media mixture, shaping the filter media mixture into a filter body. The filter body may be calcined to form a filter element. The activated carbon/metal oxide filter element may be used to remove odorous compounds, acidic gases, and volatile organic compounds from a gas.

Abstract: Isolated polynucleotides which have been derived from a variety of human tissue sources, and which encode novel secreted proteins, are provided. Also provided are methods for producing proteins using these polynucleotides, and the proteins so produced.

Abstract: Isolated polynucleotides which have been derived from a variety of human tissue sources, and which encode novel secreted proteins, are provided. Also provided are methods for producing proteins using these polynucleotides, and the proteins so produced.

Abstract: Isolated polynucleotides which have been derived from a variety of human tissue sources, and which encode novel secreted proteins, are provided. Also provided are methods for producing proteins using these polynucleotides, and the proteins so produced.

Abstract: A rupture panel for relieving an excess pressure differential between the interior and exterior of a vessel having a wall and an opening through the wall includes a first frame section connected to the vessel wall at the opening and a pair of pressure relief panels mounted to the frame, each panel having a stitched portion, the stitched portions providing opening capability on both vacuum and burst pressure control (or on either vacuum or burst pressure control). A pair of sealing members that sandwich the pair of pressure relief panels there between are provided, one of the sealing members engaging one of the pressure relief panels, the other sealing member engaging the other pressure relief panel. Each of the sealing members has a sealing surface that covers a stitched portion of an adjacent relief panel.

Abstract: Isolated polynucleotides which have been derived from a variety of human tissue sources, and which encode novel secreted proteins, are provided. Also provided are methods for producing proteins using these polynucleotides, and the proteins so produced.

Abstract: A method and apparatus are disclosed for identifying protein-coding regions in a nucleic acid sequence. In order to predict the coding regions within a sequence, a single metric is used without reference or comparison to a predetermined noise level or signal-to-noise ratio. This single metric, periodicity at ⅓, is analyzed using a discrete cosine transformation (DiCTion) function. For each open reading frame or sequence region, a score is generated using the discrete cosine transformation function. Regions within a sequence that have a score above a predetermined threshold are identified as protein-coding regions. The aspects of the invention may also be applied to gather other information from sequences, such as the location of the borders of a putative coding region, within a genomic sequence.

Abstract: A sanitary rupture disk apparatus includes a rupture disk member having a periphery and a stitched portion, preferably positioned next to the periphery. A hinge area that is unstitched is provided also at the periphery of the rupture disk member. A peripheral holder or support engages the periphery of the disk member, the peripheral support being comprised of a pair of backup rings and a flexible, preferably polymeric member. The polymeric member can be in the form of a two-part flexible sanitary gasket. A pair of annular flanges of the flexible gasket extend radially inwardly of the peripheral support, each of the flanges overlapping and sealing the stitched portion of the disk member, the flanges enabling a pressure loading of the disk member.

Abstract: A hinge assembly which has a limited number of stable positions and in which the hinge automatically moves to the closest of such stable positions is disclosed. The movement of the hinge is accomplished in one illustrative embodiment by positioning the protrusion on one of a pair of ramps inclined opposite to one another and toward the adjacent recess so that the parts of the hinge rotate relative to one another, moving the protrusion into the adjacent recess. The protrusion is pressed against the ramps and the grooves by a connecting portion that joins the arm portions and is flexed when the hinge parts are assembled so as to bias the arm portions toward one another.