Patents by Inventor James R. Heath

James R. Heath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200040293
    Abstract: Disclosed herein are methods and devices for antigen-specific T cell identification or neoantigen identification. Also disclosed herein are devices for separating and isolating antigen- specific T cells or other particles of a certain size from a population of particles of different sizes. Also describe herein are methods and devices for the separation and isolation of barcoded T cells from other nanoparticles containing barcodes for subsequent analysis and further processing of a viable T cell.
    Type: Application
    Filed: November 1, 2017
    Publication date: February 6, 2020
    Inventors: Songming Peng, James R. Heath, William Chour, Alphonsus H.c. Ng, Sung Yang, Jongchan Choi, Ji-Chul Hyun
  • Patent number: 10481158
    Abstract: Compositions and methods for isolating patient-derived antigen-specific T cells include an antigen complex having a polynucleotide barcoded nanoparticle sorting agent complexed with a peptide-loaded streptavidin major histocompatability complex (MHC) tetramer, the barcoding technology allowing for high fidelity screening of a library of the antigen complexes to readily isolate and identify antigen-specific T cells.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: November 19, 2019
    Assignee: California Institute of Technology
    Inventors: James R. Heath, Songming Peng
  • Patent number: 10349959
    Abstract: A medical retrieval device of an embodiment of the present disclosure includes a proximal handle, a sheath, and a retrieval assembly. The sheath extends from the handle and includes a lumen and a distal end opposite the handle. The retrieval assembly is moveable relative to the sheath to achieve a collapsed position of the retrieval assembly within the lumen and an expanded position of the retrieval assembly when extended outside the lumen. The retrieval assembly includes a plurality of legs. At least one of the legs includes a wire having an inner core at least partially surrounded by an outer layer.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: July 16, 2019
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: James A. Teague, Eric Cheng, Jason W. Kear, Juli L. Curtis, Kevin R. Heath
  • Publication number: 20190195869
    Abstract: Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems.
    Type: Application
    Filed: November 14, 2018
    Publication date: June 27, 2019
    Inventors: Rong Fan, Habib Ahmad, James R. Heath
  • Publication number: 20190177367
    Abstract: The present application provides stable peptide-based Akt capture agents and the use thereof as detection, diagnosis, and treatment agents. The application further provides novel methods of developing stable peptide-based capture agents, including Akt capture agents, using iterative on-bead in situ click chemistry.
    Type: Application
    Filed: February 20, 2019
    Publication date: June 13, 2019
    Inventors: James R. Heath, Arundhati Nag, Samir Das, Kaycie M. Deyle, Steven Wesley Millward, Paul Edward Kearney
  • Patent number: 10305014
    Abstract: Methods and devices for controlling thermal conductivity and thermoelectric power of semiconductor nanowires are described. The thermal conductivity and the thermoelectric power are controlled substantially independently of the electrical conductivity of the nanowires by controlling dimensions and doping, respectively, of the nanowires. A thermoelectric device comprising p-doped and n-doped semiconductor nanowire thermocouples is also shown, together with a method to fabricate alternately p-doped and n-doped arrays of silicon nanowires.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: May 28, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Akram Boukai, Yuri Bunimovich, William A. Goddard, James R. Heath, Jamil Tahir-Kheli
  • Patent number: 10221214
    Abstract: The present application provides stable peptide-based Akt capture agents and the use thereof as detection, diagnosis, and treatment agents. The application further provides novel methods of developing stable peptide-based capture agents, including Akt capture agents, using iterative on-bead in situ click chemistry.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: March 5, 2019
    Assignee: INDI MOLECULAR, INC.
    Inventors: James R. Heath, Arundhati Nag, Samir Das, Kaycie M. Deyle, Steven Wesley Millward, Paul Edward Kearney
  • Publication number: 20180364253
    Abstract: The present application provides stable peptide-based IL-17F and IL-17A capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.
    Type: Application
    Filed: June 15, 2018
    Publication date: December 20, 2018
    Inventors: Heather Agnew, Bert Tsunyin Lai, Suresh Mark Pitram, Blake Farrow, James R. Heath, David Bunck, Jingxin Liang, Arundhati Nag, Samir Das
  • Publication number: 20180319844
    Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pm), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.
    Type: Application
    Filed: July 10, 2018
    Publication date: November 8, 2018
    Inventors: Ryan K. Henning, Ashwin N. Ram, Samir Das, Arundhati Nag, James R. Heath
  • Publication number: 20180284123
    Abstract: Disclosed are devices, compositions, and methods useful for assessing properties of compounds and molecules, such a binding, kinetic, and enzymatic properties, simultaneously for multiple compounds or molecules and/or under multiple conditions, efficiently, rapidly, and combinations of these. By using certain features alone or together in the save device or assay, the disclosed devices, compositions, and methods provide improvements over, and solve problems present in, prior assay devices and methods.
    Type: Application
    Filed: March 30, 2018
    Publication date: October 4, 2018
    Inventors: James R. Heath, Amy M. McCarthy, Jungwoo Kim
  • Patent number: 10017540
    Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pra), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: July 10, 2018
    Assignee: California Institute of Technology
    Inventors: Ryan K. Henning, Ashwin N. Ram, Samir Das, Arundhati Nag, James R. Heath
  • Publication number: 20180072772
    Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.
    Type: Application
    Filed: August 17, 2017
    Publication date: March 15, 2018
    Inventors: Kaycie Deyle, Blake Farrow, James R. Heath
  • Patent number: 9913875
    Abstract: The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: March 13, 2018
    Assignees: California Institute of Technology, Indi Molecular, Inc.
    Inventors: Blake Farrow, James R. Heath, Heather Dawn Agnew
  • Patent number: 9863956
    Abstract: Techniques for differentiating isobaric species are described. An isobaric species may be substituted with a tagging species identified using mass spectrometry. The isobaric species may be a subunit of a first polymer having a defined sequence, e.g., the isobaric species may be an amino acid in a protein or a peptide sequence. A tagging species may be substituted for the isobaric species in a second polymer having an otherwise identical sequence as the first polymer. The second polymer may have the same number of sequences as the first polymer, and substantially the same sequence of subunits, with a few exceptions such as the tagging species for the isobaric species. The first polymer and the second polymer may be prepared in the same reaction vessel. A polymer/protein of defined subunit sequence containing an isobaric species or a tagging species may be analyzed by mass spectrometry to determine the sequence.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: January 9, 2018
    Assignee: Agency for Science, Technology and Research
    Inventors: James R. Heath, Su Seong Lee, Jaehong Lim, Junhoe Cha, Sylvia Tan, Shi Yun Yeo
  • Publication number: 20170218021
    Abstract: The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.
    Type: Application
    Filed: January 31, 2017
    Publication date: August 3, 2017
    Inventors: Blake Farrow, James R. Heath, Heather Dawn Agnew
  • Publication number: 20170138942
    Abstract: Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems.
    Type: Application
    Filed: November 22, 2016
    Publication date: May 18, 2017
    Inventors: Rong Fan, Habib Ahmad, James R. Heath
  • Patent number: 9595653
    Abstract: Phononic structures, devices related to phononic structures, and methods related to fabrication of the phononic structures are described. The phononic structure can include a sheet of material, where the sheet of material can include a plurality of regions. Adjacent regions in the sheet of material can have dissimilar phononic patterns.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: March 14, 2017
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Slobodan Mitrovic, Jen-Kan Yu, James R. Heath
  • Publication number: 20170069818
    Abstract: Phononic structures, devices related to phononic structures, and methods related to fabrication of the phononic structures are described. The phononic structure can include a sheet of material, where the sheet of material can include a plurality of regions. Adjacent regions in the sheet of material can have dissimilar phononic patterns.
    Type: Application
    Filed: October 31, 2016
    Publication date: March 9, 2017
    Inventors: Slobodan MITROVIC, Jen-Kan YU, James R. HEATH
  • Publication number: 20170052199
    Abstract: The present application provides stable peptide-based IL-17F capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.
    Type: Application
    Filed: July 15, 2016
    Publication date: February 23, 2017
    Inventors: James R. Heath, Heather Agnew, Blake Farrow, David Bunck, Jingxin Liang, Arundhati Nag, Samir Das, Bert Tsunyin Lai, Suresh Mark Pitram
  • Publication number: 20170003288
    Abstract: Compositions and methods for isolating patient-derived antigen-specific T cells include an antigen complex having a polynucleotide barcoded nanoparticle sorting agent complexed with a peptide-loaded streptavidin major histocompatability complex (MHC) tetramer, the barcoding technology allowing for high fidelity screening of a library of the antigen complexes to readily isolate and identify antigen-specific T cells.
    Type: Application
    Filed: June 1, 2016
    Publication date: January 5, 2017
    Inventors: James R. Heath, Songming Peng