Patents by Inventor James R. HITCHIN

James R. HITCHIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PARG INHIBITORY COMPOUNDS
    Publication number: 20210380539
    Abstract: The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
    Type: Application
    Filed: March 17, 2021
    Publication date: December 9, 2021
    Inventors: Alison E. MCGONAGLE, Allan M. JORDAN, Bohdan WASZKOWYCZ, Colin P. HUTTON, Ian D. WADDELL, James R. HITCHIN, Kate M. SMITH, Niall M. HAMILTON
  • PARG inhibitory compounds
    Patent number: 10995073
    Abstract: The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: May 4, 2021
    Assignee: Cancer Research Technology Limited
    Inventors: Alison E. McGonagle, Allan M. Jordan, Bodhan Waszkowycz, Colin P. Hutton, Ian D. Waddell, James R. Hitchin, Kate M. Smith, Niall M. Hamilton
  • PARG INHIBITORY COMPOUNDS
    Publication number: 20200165208
    Abstract: The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
    Type: Application
    Filed: October 24, 2019
    Publication date: May 28, 2020
    Inventors: Alison E. MCGONAGLE, Allan M. JORDAN, Bodhan WASZKOWYCZ, Colin P. HUTTON, Ian D. WADDELL, James R. HITCHIN, Kate M. SMITH, Niall M. HAMILTON
  • PARG inhibitory compounds
    Patent number: 10508086
    Abstract: The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: December 17, 2019
    Assignee: Cancer Research Technology Limited
    Inventors: Alison E. McGonagle, Allan M. Jordan, Bohdan Waszkowycz, Colin P. Hutton, Ian D. Waddell, James R. Hitchin, Kate M. Smith, Niall M. Hamilton
  • 2,4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG
    Patent number: 10239843
    Abstract: The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: March 26, 2019
    Assignee: CANCER RESEARCH TECHNOLOGY LIMITED
    Inventors: Alison E. McGonagle, Allan Jordan, Bohdan Waszkowycz, Colin Hutton, Ian Waddell, James R. Hitchin, Kate Mary Smith, Niall M. Hamilton
  • PARG INHIBITORY COMPOUNDS
    Publication number: 20180194738
    Abstract: The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
    Type: Application
    Filed: December 17, 2015
    Publication date: July 12, 2018
    Inventors: Alison E. MCGONAGLE, Allan M. JORDAN, Bohdan WASZKOWYCZ, Colin P. HUTTON, Ian D. WADDELL, James R. HITCHIN, Kate M. SMITH, Niall M. HAMILTON
  • 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG
    Publication number: 20180016242
    Abstract: The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
    Type: Application
    Filed: December 11, 2015
    Publication date: January 18, 2018
    Inventors: Alison E. MCGONAGLE, Allan JORDAN, Bohdan WASZKOWYCZ, Colin HUTTON, Ian WADDELL, James R. HITCHIN, Kate Mary SMITH, Niall M. HAMILTON