Patents by Inventor James R. M. Sanford
James R. M. Sanford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5595664Abstract: An analyzer system for automatic column chromatography includes chromatographic columns which are mounted in a rack. A drop removal mechanism system shakes the rack to transfer the last drop of eluate from the tip of a chromatographic column to a receptacle below the tip before the column is repositioned over another receptacle and another fluid or operation is introduced into the column. This prevents one eluate from contaminating another. The chromatographic column may have an upper end which is sealed by a foil member. During use, the foil member is ruptured by lowering a pressure cylinder with a seal-punching head against it. The pressure cylinder, which is part of the pressure tip unit, is then withdrawn so that fluid can be introduced into the column via the ruptured foil member. The pressure tip unit is then lowered into sealing engagement with the column so that pressure can be applied via a bore in the pressure cylinder.Type: GrantFiled: June 6, 1995Date of Patent: January 21, 1997Assignee: Helena Laboratories CorporationInventors: James R. M. Sanford, Patrick M. Frank, Joseph H. Golias, William C. Jennings
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Patent number: 5589063Abstract: An analyzer system for automatic column chromatography includes chromatographic columns which are mounted in a rack. A drop removal mechanism system shakes the rack to transfer the last drop of eluate from the tip of a chromatographic column to a receptacle below the tip before the column is repositioned over another receptacle and another fluid or operation is introduced into the column. This prevents one eluate from contaminating another. The chromatographic column may have an upper end which is sealed by a foil member. During use, the foil member is ruptured by lowering a pressure cylinder with a seal-punching head against it. The pressure cylinder, which is part of the pressure tip unit, is then withdrawn so that fluid can be introduced into the column via the ruptured foil member. The pressure tip unit is then lowered into sealing engagement with the column so that pressure can be applied via a bore in the pressure cylinder.Type: GrantFiled: June 6, 1995Date of Patent: December 31, 1996Assignee: Helena Laboratories CorporationInventors: James R. M. Sanford, Patrick M. Frank, Joseph H. Golias, William C. Jennings
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Patent number: 5441645Abstract: An analyzer system for automatic column chromatography includes chromatographic columns which are mounted in a rack. A drop removal mechanism system shakes the rack to transfer the last drop of eluate from the tip of a chromatographic column to a receptacle below the tip before the column is repositioned over another receptacle and another fluid or operation is introduced into the column. This prevents one eluate from contaminating another. The chromatographic column may have an upper end which is sealed by a foil member. During use, the foil member is ruptured by lowering a pressure cylinder with a seal-punching head against it. The pressure cylinder, which is part of the pressure tip unit, is then withdrawn so that fluid can be introduced into the column via the ruptured foil member. The pressure tip unit is then lowered into sealing engagement with the column so that pressure can be applied via a bore in the pressure cylinder.Type: GrantFiled: September 16, 1994Date of Patent: August 15, 1995Assignee: Helena Laboratories CorporationInventors: James R. M. Sanford, Patrick M. Frank, Joseph H. Golias, William C. Jennings
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Patent number: 5358641Abstract: An analyzer system for automatic column chromatography includes chromatographic columns which are mounted in a rack. A drop removal mechanism system shakes the rack to transfer the last drop of eluate from the tip of a chromatographic column to a receptacle below the tip before the column is repositioned over another receptacle and another fluid or operation is introduced into the column. This prevents one eluate from contaminating another. The chromatographic column may have an upper end which is sealed by a foil member. During use, the foil member is ruptured by lowering a pressure cylinder with a seal-punching head against it. The pressure cylinder, which is part of the pressure tip unit, is then withdrawn so that fluid can be introduced into the column via the ruptured foil member. The pressure tip unit is then lowered into sealing engagement with the column so that pressure can be applied via a bore in the pressure cylinder.Type: GrantFiled: May 10, 1993Date of Patent: October 25, 1994Assignee: Helena Laboratories CorporationInventors: James R. M. Sanford, Patrick M. Frank, Joseph H. Golias, William C. Jennings
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Patent number: 5228988Abstract: An analyzer system for automatic column chromatography includes chromatographic columns which are mounted in a rack. A drop removal mechanism system shakes the rack to transfer the last drop of eluate from the tip of a chromatographic column to a receptacle below the tip before the column is repositioned over another receptacle and another fluid or operation is introduced into the column. This prevents one eluate from contaminating another. The chromatographic column may have an upper end which is sealed by a foil member. During use, the foil member is ruptured by lowering a pressure cylinder with a seal-punching head against it. The pressure cylinder, which is part of the pressure tip unit, is then withdrawn so that fluid can be introduced into the column via the ruptured foil member. The pressure tip unit is then lowered into sealing engagement with the column so that pressure can be applied via a bore in the pressure cylinder.Type: GrantFiled: October 22, 1991Date of Patent: July 20, 1993Assignee: Helena Laboratories CorporationInventors: James R. M. Sanford, Patrick M. Frank, Joseph H. Golias, William C. Jennings
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Patent number: 5207918Abstract: An analyzer system for automatic column chromatography, and method for its use, includes an array of chromatograph columns and multi-cell cuvettes associated with each column. Chromatographic separation takes place under a constant, low fluid pressure. A pressure system distributes air to each column during chromatographic separation but prevents leakage of air if the column array is partially empty. The multi-cell cuvette collects and separates the eluates associated with a single column. The system provides for automatic removal of caps from the bottoms of the chromatograph columns and provides for automatic optical density reading.Type: GrantFiled: May 31, 1991Date of Patent: May 4, 1993Assignee: Helena Laboratories CorporationInventors: James R. M. Sanford, Patrick M. Frank, Joseph H. Gollas, William C. Jennings
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Patent number: 5200045Abstract: A method and apparatus for removing unreacted protein and unreacted antisera from a gel plate during immunofixation electrophoresis. The apparatus includes a pressure plate movable toward and away from a fixed base for exerting a desired force on the electrophoresis plate. A stop member limits the movement of the pressure plate toward the fixed base thus controlling the amount of pressure on the electrophoresis plate.Type: GrantFiled: June 22, 1992Date of Patent: April 6, 1993Assignee: Helena Laboratories CorporationInventors: Barbara M. Warren, James R. M. Sanford, Edgar F. Neely, Robert J. Sarrine
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Patent number: 5045208Abstract: An analyzer system for automatic column chromatography, and method for its use, includes an array of chromatograph columns and multi-cell cuvettes associated with each column. Chromatographic separation takes place under a constant, low fluid pressure. A pressure system distributes air to each column during chromatographic separation but prevents leakage of air if the column array is partially empty. The multi-cell cuvette collects and separates the eluates associated with a single column. The system provides for automatic removal of caps from the bottoms of the chromatograph columns and provides for automatic optical density reading.Type: GrantFiled: October 27, 1989Date of Patent: September 3, 1991Assignee: Helena Laboratories CorporationInventors: James R. M. Sanford, Patrick M. Frank, Joseph H. Golias, William C. Jennings
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Patent number: 4759838Abstract: A container for protecting and enclosing an electrophoretic support medium is disclosed. The container includes a top portion and a bottom portion, which when closed sealingly engage one another to form a substantially air-tight cavity therein. The bottom portion has a recess formed therein for accommodating the support medium and at least a portion of the recess has a substantially smooth planar surface. The bottom recess is defined by a protruding continuous rim which has a plurality of nubs protruding into said recess and engagable with the base sheet of the support medium, whereby the support medium is retained within the recess.Type: GrantFiled: January 5, 1987Date of Patent: July 26, 1988Assignee: Helena Laboratories CorporationInventors: David G. Mayes, James R. M. Sanford, Eric H. Petersen
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Patent number: 4741814Abstract: A container for protecting and enclosing an electrophoretic support medium is disclosed. The container includes a first portion and a second portion slidingly engageable with one another, whereby when closed they sealingly engage one another to form a substantially air-tight cavity therein. The first portion has a first recess defined by a protruding rim for accommodating a portion of the support medium therein. The second portion has a second recess defined by a protruding rim for accommodating the remainder of the support medium therein. The protruding rims are spaced apart from the bottoms of each portion and engagable with the base sheet of the support medium, whereby the support medium is retained within the recesses between the rims and the bottoms. The bottoms each have a substantially smooth planar surface to facilitate secure retention of the support medium.Type: GrantFiled: February 12, 1987Date of Patent: May 3, 1988Assignee: Helena Laboratories CorporationInventors: David G. Mayes, James R. M. Sanford, Eric H. Petersen
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Patent number: 4511533Abstract: A test kit for preparing a chemical test pad used in testing for the presence of occult blood in a specimen. The test kit is a foil package enclosing an absorbant pad bearing a peroxygen agent and a solution of guaiac in alcohol in a separate packet or compartment from the absorbant pad. The separate packet or compartment being rupturable by applying hand pressure to the outside of the foil package to mix the peroxygen agent powder on the test pad and the guaiac solution prior to removing the absorbant pad from the foil package. The method relates to performing a medical test by activating a test pad bearing one reagent by applying another reagent thereto while remaining wholly within a protective foil package. According to the method a test pad containing the peroxygen agent is wetted with a solution of guaiac in alcohol prior to removal from the protective foil package and exposure to a specimen of fecal material and water in a test for occult blood.Type: GrantFiled: October 7, 1982Date of Patent: April 16, 1985Assignee: Helena Laboratories CorporationInventors: Philip A. Guadagno, James R. M. Sanford