Patents by Inventor James R. Matson
James R. Matson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230149613Abstract: The invention relates generally to methods of treating or reducing the risk of Cytokine Release Syndrome (CRS), treating or reducing the risk of Tumor Lysis Syndrome (TLS), or increasing drug exposure in a subject undergoing CAR T-cell therapy or chemotherapy. The methods comprise contacting blood from the subject with an extracorporeal membrane having a plurality of pores having an average pore size of at least 60 kDa to permit inflammatory cytokines, other inflammatory molecules, or metabolites to pass through the pores and out of the blood that is returned back to the subject.Type: ApplicationFiled: June 28, 2021Publication date: May 18, 2023Inventor: James R. Matson
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Publication number: 20230036583Abstract: The invention relates generally to methods of improving function of a transplanted organ, treating or preventing primary graft dysfunction of a transplanted organ, treating or preventing acute rejection of a transplanted organ, treating or preventing delayed graft function, or achieving a clinical endpoint indicative of a successful organ transplant in a recipient of the transplanted organ which comprise contacting blood from the recipient with an extracorporeal membrane having a plurality of pores having an average pore size of at least 40 kDa, 50 kDa or 60 kDa to permit inflammatory cytokines and other inflammatory molecules to pass through the pores and out of the blood that is returned back to the recipient.Type: ApplicationFiled: December 30, 2020Publication date: February 2, 2023Inventors: James R. Matson, Christopher Jaynes, Charles Jack Fisher, JR.
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Publication number: 20220273855Abstract: The invention relates generally to methods of preparing one or more organs from a donor for transplantation to a recipient comprising passing blood from the donor through an extracorporeal membrane having a plurality of pores having an average pore size of at least 60 kDa.Type: ApplicationFiled: July 31, 2020Publication date: September 1, 2022Inventors: Charles Jack Fisher, Christopher Jaynes, James R. Matson
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Patent number: 8597516Abstract: The present invention relates to a method and system for using a very large pore hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.Type: GrantFiled: October 28, 2010Date of Patent: December 3, 2013Assignee: Immunocept, L.L.C.Inventors: David Radunsky, James R. Matson, Patrice A. Lee
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Patent number: 8535258Abstract: Hemofiltration systems and methods to treat an Inflammatory Mediator Related Disease in a patients, including chronic and acute diseases, may include a hemofilter and an adsorptive device. The systems and methods may further include one or more therapeutic agents administered to the patient. The hemofilter removes ultrafiltrate from a blood stream extracted from the patient to create a filtered blood stream and an ultrafiltrate stream. The adsorptive device may include one or more adsorbent materials and may be used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream may be selectively combined with the filtered blood stream and together with the filtered blood stream may be returned to the mammal. Other systems and methods are disclosed.Type: GrantFiled: July 1, 2010Date of Patent: September 17, 2013Assignee: Immunocept, L.L.C.Inventor: James R. Matson
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Publication number: 20110040228Abstract: The present invention relates to a method and system for using a very large pore hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.Type: ApplicationFiled: October 28, 2010Publication date: February 17, 2011Inventors: David Radunsky, James R. Matson, Patrice A. Lee
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Publication number: 20110004142Abstract: Hemofiltration systems and methods to treat an Inflammatory Mediator Related Disease in a patients, including chronic and acute diseases, may include a hemofilter and an adsorptive device. The systems and methods may further include one or more therapeutic agents administered to the patient. The hemofilter removes ultrafiltrate from a blood stream extracted from the patient to create a filtered blood stream and an ultrafiltrate stream. The adsorptive device may include one or more adsorbent materials and may be used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream may be selectively combined with the filtered blood stream and together with the filtered blood stream may be returned to the mammal. Other systems and methods are disclosed.Type: ApplicationFiled: July 1, 2010Publication date: January 6, 2011Inventor: James R. Matson
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Patent number: 7837878Abstract: The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.Type: GrantFiled: April 17, 2009Date of Patent: November 23, 2010Assignee: Immunocept, L.L.C.Inventors: David Radunsky, James R. Matson, Patrice A. Lee
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Patent number: 7758533Abstract: A hemofiltration system and method to treat an Inflammatory Mediator Related Disease in a mammal, including chronic and acute diseases, include a hemofilter and an adsorptive device. The hemofilter removes ultrafiltrate from a blood stream extracted from the mammal to create a filtered blood stream and an ultrafiltrate stream. The adsorptive device may include one or more adsorbent materials and may be used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream may be selectively combined with the filtered blood stream and together with the filtered blood stream may be returned to the mammal.Type: GrantFiled: November 5, 2007Date of Patent: July 20, 2010Assignee: Immunocept, L.L.C.Inventor: James R. Matson
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Publication number: 20090204050Abstract: The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.Type: ApplicationFiled: April 17, 2009Publication date: August 13, 2009Applicant: IMMUNOCEPT, L.L.C.Inventors: David Radunsky, James R. Matson, Patrice A. Lee
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Patent number: 7524420Abstract: The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood. The replacement fluid may include pharmaceutical grade balanced salt solution containing albumin and/or other target receptor molecules and/or other physiological molecules in a sufficient concentration to adequately replenish ongoing losses.Type: GrantFiled: March 8, 2004Date of Patent: April 28, 2009Assignee: Immunocept, L.L.C.Inventors: David Radunsky, James R. Matson, Patrice A. Lee
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Patent number: 7520992Abstract: The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.Type: GrantFiled: March 23, 2006Date of Patent: April 21, 2009Assignee: Imunocept, L.L.C.Inventors: David Radunsky, James R. Matson, Patrice A. Lee
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Publication number: 20080110830Abstract: A hemofiltration system and method to treat an Inflammatory Mediator Related Disease in a mammal, including chronic and acute diseases, include a hemofilter and an adsorptive device. The hemofilter removes ultrafiltrate from a blood stream extracted from the mammal to create a filtered blood stream and an ultrafiltrate stream. The adsorptive device may include one or more adsorbent materials and may be used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream may be selectively combined with the filtered blood stream and together with the filtered blood stream may be returned to the mammal.Type: ApplicationFiled: November 5, 2007Publication date: May 15, 2008Inventor: James R. Matson
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Patent number: 7291122Abstract: A hemofiltration system and method to treat an Inflammatory Mediator Related Disease in a mammal, including chronic and acute diseases, include a hemofilter and an adsorptive device. The hemofilter removes ultrafiltrate from a blood stream extracted from the mammal to create a filtered blood stream and an ultrafiltrate stream. The adsorptive device may include one or more adsorbent materials and may be used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream may be selectively combined with the filtered blood stream and together with the filtered blood stream may be returned to the mammal.Type: GrantFiled: May 12, 2004Date of Patent: November 6, 2007Assignee: Immunocept, L.L.C.Inventor: James R. Matson
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Publication number: 20040199099Abstract: A hemofiltration system for a mammal is provided with a hemofilter and an adsorbent device. The hemofilter removes ultrafiltrate from a blood stream extracted from the mammal to create a filtered blood stream and an ultrafiltrate stream. The adsorbent device has one or more adsorbent materials and is used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter removing inflammatory mediators that cause inflammatory mediator related disease, sepsis, and SIRS/MODS/MOSF to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream is selectively combined with the filtered blood stream and together with the filtered blood stream is returned to the mammal.Type: ApplicationFiled: April 16, 2004Publication date: October 7, 2004Inventors: James R. Matson, Patrice A. Lee
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Publication number: 20040173530Abstract: The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.Type: ApplicationFiled: March 8, 2004Publication date: September 9, 2004Applicant: Immunocept, L.L.C.Inventors: David Radunsky, James R. Matson, Patrice A. Lee
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Patent number: 6787040Abstract: The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.Type: GrantFiled: May 15, 2001Date of Patent: September 7, 2004Assignee: Immunocept, L.L.C.Inventors: David Radunsky, James R. Matson, Patrice A. Lee
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Patent number: 6736972Abstract: The present invention relates to a method and system for providing hemofiltration for reducing inflammatory mediator related diseases. In one form, a hemofiltration system for treating inflammatory mediator related diseases is disclosed. The system includes a hemofilter to receive blood from a specimen, the hemofilter removing selective inflammatory mediators from the blood and at least one therapeutic agent used in association with the hemofilter, the therapeutic agent to reduce adverse inflammatory mediator effects.Type: GrantFiled: March 23, 2001Date of Patent: May 18, 2004Assignee: Immunocept, L.L.C.Inventor: James R. Matson
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Patent number: 6730266Abstract: A hemofiltration system for a mammal is provided with a hemofilter and an adsorbent device. The hemofilter removes ultrafiltrate from a blood stream extracted from the mammal to create a filtered blood stream and an ultrafiltrate stream. The adsorbent device has one or more adsorbent materials and is used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter removing inflammatory mediators that cause inflammatory mediator related disease, sepsis, and SIRS/MODS/MOSF to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream is selectively combined with the filtered blood stream and together with the filtered blood stream is returned to the mammal.Type: GrantFiled: July 25, 2001Date of Patent: May 4, 2004Assignee: Immunocept, L.L.C.Inventors: James R. Matson, Patrice A. Lee
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Publication number: 20040060866Abstract: The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.Type: ApplicationFiled: May 15, 2001Publication date: April 1, 2004Applicant: Immunocept, L.L.C.Inventors: David Radunsky, James R. Matson, Patrice A. Lee