Patents by Inventor James R. Pribish

James R. Pribish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidine hydrazide compounds as PGDS inhibitors
    Patent number: 8258130
    Abstract: This invention is directed to a compound of formula (I): wherein R1, R2, R3, R4 and L1 are as defined herein, a pharmaceutical composition comprising the compound, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma and/or chronic obstructive pulmonary disease (COPD).
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: September 4, 2012
    Assignee: Sanofi
    Inventors: Suzanne C Aldous, Michael W Fennie, John Z Jiang, Stanly John, Lan Mu, Brian Pedgrift, James R Pribish, Barbara S Rauckman, Jeffrey S Sabol, Grzegorz T Stoklosa, Sukanthini Thurairatnam, Christopher Loren Vandeusen
  • PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS
    Publication number: 20100048568
    Abstract: This invention is directed to a compound of formula (I): wherein R1, R2, R3, R4 and L1 are as defined herein, a pharmaceutical composition comprising the compound, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma and/or chronic obstructive pulmonary disease (COPD).
    Type: Application
    Filed: September 30, 2009
    Publication date: February 25, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Suzanne C. Aldous, Michael W. Fennie, John Z. Jiang, Stanly John, Lan Mu, Brian Pedgrift, James R. Pribish, Barbara Rauckman, Jeffrey S. Sabol, Grzegorz T. Stoklosa, Sukanthini Thurairatnam, Christopher L. Vandeusen
  • 4-aza steroids
    Patent number: 6365597
    Abstract: The invention related to 4-aza-17&bgr;-(cyclopropoxy)-androst-5&agr;-androstan-3-one, 4-aza-17&bgr;-(cyclopropylamino)-androst-4-en-3-one and related compounds and to compositions incorporating these compounds, as well as the inhibition of C17-20 lyase, 5&agr;-reductase and C17&agr;-hydroxylase and to the use of these compounds in the treatment of androgen and estrogen mediated disorders, including benign prostatic hyperplasia, androgen mediated prostate cancer, estrogen mediated breast cancer and to DHT-mediated disorders such as acne. Disorders relating to the oversynthesis of cortisol, for example, Cushing's Syndrome, are also included. The treatment of androgen-dependent disorders also includes a combination therapy with known androgen-receptor antagonists, such as flutamide.
    Type: Grant
    Filed: February 11, 1997
    Date of Patent: April 2, 2002
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: James R. Pribish, Cynthia A. Gates, Philip M. Weintraub
  • Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents
    Patent number: 5505931
    Abstract: Novel compounds, their preparation and their use as bifunctional acid-labile crosslinking agents which are cleavable in an acid environment at a pH of below about 5.0 allowing for the controlled release of nucleophilic groups attached thereto are disclosed.
    Type: Grant
    Filed: March 4, 1993
    Date of Patent: April 9, 1996
    Assignee: The Dow Chemical Company
    Inventor: James R. Pribish
  • Melt processable thermotropic aromatic copolyester derived from hydroxy phenoxy benzoic acids and hydroxy benzoic acid
    Patent number: 4945150
    Abstract: The invention relates to a class of copolyesters which display optical anisotropy in the molten state and to the shaped articles, fibers and films obtained from the optically anisotropic melts. the copolyesters comprise recurring structural units (a) independently each occurrence selected from the group consisting of Formulas I and II; and recurring structural units (b) independently each occurrence selected from the group consisting of Formula III; ##STR1## wherein R independently each occurrence is a chemically inert substituent.
    Type: Grant
    Filed: May 4, 1989
    Date of Patent: July 31, 1990
    Assignee: The Dow Chemical Company
    Inventors: William B. Marshall, James R. Pribish, James L. Brewbaker