Patents by Inventor James R. Pruitt

James R. Pruitt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Guanidine mimics as factor Xa inhibitors
    Patent number: 7235575
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings D-E represent guanidine mimics, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: June 26, 2007
    Assignee: Bristol Myers Squibb Company
    Inventors: Patrick Y. Lam, Charles G. Clark, Celia Dominguez, John M. Fevig, Qi Han, Renhua Li, Donald J P Pinto, James R. Pruitt, Mimi L. Quan
  • Inhibitors of proteins that bind phosphorylated molecules
    Patent number: 7141596
    Abstract: The present invention provides compounds that can modulate the activity of a target protein, such as a phosphatase, that selectively binds phosphorylated peptides or proteins. The present compounds can be useful in treating diseases or disorders, including, for example, diabetes and obesity, that are connected directly or indirectly to the activity of the target protein.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: November 28, 2006
    Assignee: Incyte Corporation
    Inventors: Andrew P. Combs, Eddy Wai Tsun Yue, Michael J. Bower, Wenyu Zhu, Matthew L. Crawley, Richard B. Sparks, James R. Pruitt, Amy Takvorian
  • Guanidine mimics factor Xa inhibitors
    Patent number: 6958356
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings D-E represent guanidine mimics, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: October 25, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Patrick Y. Lam, Charles G. Clark, Celia Dominguez, John M. Fevig, Amy Qi Han, Renhua Li, Donald J. Pinto, James R. Pruitt, Mimi L. Quan
  • N-ureidoheterocycloalkyl-piperidines as modulators of chemokine receptor activity
    Patent number: 6949546
    Abstract: The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: September 27, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Soo S. Ko, James R. Pruitt, Dean A. Wacker, Douglas G. Batt
  • Guanidine mimics as factor Xa inhibitors
    Patent number: 6906070
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings D-E represent guanidine mimics, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: June 14, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Patrick Y. Lam, Charles G. Clark, Celia Dominguez, John M. Fevig, Qi Han, Renhua Li, Donald J. P. Pinto, James R. Pruitt, Mimi L. Quan
  • Nitrogen containing heterobicycles as factor Xa inhibitors
    Patent number: 6858616
    Abstract: The present application describes nitrogen containing heterobicyclics and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: February 22, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: John M. Fevig, Joseph Cacciola, Charles G. Clark, Qi Han, Patrick Yuk Sun Lam, Donald J. P. Pinto, James R. Pruitt, Mimi L. Quan, Karen A. Rossi
  • N-ureidoheterocycloalkyl-piperidines as modulators of chemokine receptor activity
    Publication number: 20040058961
    Abstract: The present application describes modulators of CCR3 of formula (I): 1
    Type: Application
    Filed: July 10, 2003
    Publication date: March 25, 2004
    Inventors: Soo S. Ko, James R. Pruitt, Dean A, Wacker, Douglas G. Batt
  • N-ureidoheterocycloalkyl-piperidines as modulators of chemokine receptor activity
    Patent number: 6627629
    Abstract: The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: September 30, 2003
    Assignee: Bristol-Myers Squibb Pharma
    Inventors: Soo S. Ko, James R. Pruitt, Dean A. Wacker, Douglas G. Batt
  • Inhibitors of factor Xa with a neutral P1 specificity group
    Patent number: 6602895
    Abstract: The present application describes inhibitors of factor Xa with a neutral P1 specificity group of formula I: or pharmaceutically acceptable salt forms thereof, wherein R and E may be groups such as methoxy and halo.
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: August 5, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert A. Galemmo, Jr., Celia Dominguez, John M. Fevig, Qi Han, Patrick Y. Lam, Donald J. P. Pinto, James R. Pruitt, Mimi L. Quan
  • Inhibitors of factor Xa with a neutral P1 specificity group
    Publication number: 20030092740
    Abstract: The present application describes inhibitors of factor Xa with a neutral P1 specificity group of formula I: 1
    Type: Application
    Filed: May 16, 2002
    Publication date: May 15, 2003
    Inventors: Robert A. Galemmo, Celia Dominguez, John M. Fevig, Qi Han, Patrick Y. Lam, Donald J.P. Pinto, James R. Pruitt, Mimi L. Quan
  • Nitrogen containing heterobicycles as factor Xa inhibitors
    Publication number: 20030069237
    Abstract: The present application describes nitrogen containing heterobicyclics and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
    Type: Application
    Filed: April 26, 2002
    Publication date: April 10, 2003
    Inventors: John M. Fevig, Joseph Cacciola, Charles G. Clark, Qi Han, Patrick Yuk Sun Lam, Donald J.P. Pinto, James R. Pruitt, Mimi L. Quan, Karen A. Rossi
  • Novel guanidine mimics factor Xa inhibitors
    Publication number: 20030069258
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: 1
    Type: Application
    Filed: March 13, 2002
    Publication date: April 10, 2003
    Inventors: Patrick Y. Lam, Charles G. Clark, Celia Dominguez, John M. Fevig, Amy Qi Han, Renhua Li, Donald J. Pinto, James R. Pruitt, Mimi L. Quan
  • N-ureidoheterocycloalkyl-piperidines as modulators of chemokine receptor activity
    Publication number: 20030032654
    Abstract: The present application describes modulators of CCR3 of formula (I): 1
    Type: Application
    Filed: June 29, 2001
    Publication date: February 13, 2003
    Inventors: Soo S. Ko, James R. Pruitt, Dean A. Wacker, Douglas G. Batt
  • Nitrogen containing heterobicycles as factor Xa inhibitors
    Patent number: 6413980
    Abstract: The present application describes nitrogen containing heterobicyclics and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: July 2, 2002
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: John M. Fevig, Joseph Cacciola, Charles G. Clark, Qi Han, Patrick Yuk Sun Lam, Donald J.P. Pinto, James R. Pruitt, Mimi L. Quan, Karen A. Rossi
  • Inhibitors of factor Xa with a neutral P1 specificity group
    Patent number: 6403620
    Abstract: The present application describes inhibitors of factor Xa with a neutral P1 specificity group of formula I: or pharmaceutically acceptable salt forms thereof, wherein R and E may be groups such as methoxy and halo.
    Type: Grant
    Filed: September 10, 1999
    Date of Patent: June 11, 2002
    Inventors: Robert A. Galemmo, Jr., Celia Dominguez, John M. Fevig, Qi Han, Patrick Y. Lam, Donald J. P. Pinto, James R. Pruitt, Mimi L. Quan
  • Novel guanidine mimics as factor Xa inhibitors
    Publication number: 20020025963
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: 1
    Type: Application
    Filed: August 8, 2001
    Publication date: February 28, 2002
    Inventors: Patrick Y. Lam, Charles G. Clark, Celia Dominguez, John M. Fevig, Qi Han, Renhua Li, Donald Jp Pinto, James R. Pruitt, Mimi L. Quan
  • Guanidine mimics as factor Xa inhibitors
    Patent number: 6339099
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings D—E represent guanidine mimics, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: January 15, 2002
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Patrick Y. Lam, Charles G. Clark, Celia Dominguez, John M. Fevig, Qi Han, Renhua Li, Donald J. P. Pinto, James R. Pruitt, Mimi L. Quan
  • Inhibitors of factor Xa with a neutral P1 specificity group
    Patent number: 5998424
    Abstract: The present application describes inhibitors of factor Xa with a neutral P1 specificity group of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein R and E may be groups such as methoxy and halo.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: December 7, 1999
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Robert A. Galemmo, Jr., Celia Dominguez, John M. Fevig, Qi Han, Patrick Y. Lam, Donald J. P. Pinto, James R. Pruitt, Mimi L. Quan
  • Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
    Patent number: 5310929
    Abstract: Prodrugs of imidazole carboxylic acids which are AII antagonists useful in treating hypertension, pharmaceutical compositions thereof and a method of treating hypertension using such prodrugs are disclosed.
    Type: Grant
    Filed: August 6, 1992
    Date of Patent: May 10, 1994
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Robert J. Ardecky, Carol L. Ensinger, James R. Pruitt