Patents by Inventor James R. Rusche

James R. Rusche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALTERNATING TANGENTIAL FLOW RAPID HARVESTING
    Publication number: 20220325708
    Abstract: Methods and systems of harvesting a cell product from a cell culture by culturing cells in a fluid medium until the cells have produced a cell product at a harvest concentration are disclosed. The cells are cultured in a cell culture system including a bioreactor connected to an ATF device. The methods include draining fluid medium from the bioreactor through the outlet and the ATF device until the bioreactor volume reaches a predetermined volume, and the ATF column yields at an ATF outlet a liquid containing cell product and passes fluid medium with a concentration of cell product that is lower than the harvest concentration back into the bioreactor, extracting the liquid containing cell product from the ATF outlet, refilling the bioreactor with sterile phosphate buffered saline or fluid medium without any cell product, and repeating steps until a desired amount of cell product has been removed.
    Type: Application
    Filed: April 28, 2022
    Publication date: October 13, 2022
    Applicant: Repligen Corporation
    Inventors: Shashi Kiran Kudugunti, WengLong Roy Lin, John Bonham-Carter, James R. Rusche
  • Alternating tangential flow rapid harvesting
    Patent number: 11339775
    Abstract: Methods and systems of harvesting a cell product from a cell culture by culturing cells in a fluid medium until the cells have produced a cell product at a harvest concentration are disclosed. The cells are cultured in a cell culture system including a bioreactor connected to an ATF device. The methods include draining fluid medium from the bioreactor through the outlet and the ATF device until the bioreactor volume reaches a predetermined volume, and the ATF column yields at an ATF outlet a liquid containing cell product and passes fluid medium with a concentration of cell product that is lower than the harvest concentration back into the bioreactor, extracting the liquid containing cell product from the ATF outlet, refilling the bioreactor with sterile phosphate buffered saline or fluid medium without any cell product, and repeating steps until a desired amount of cell product has been removed.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: May 24, 2022
    Assignee: Repligen Corporation
    Inventors: Shashi Kiran Kudugunti, WengLong Roy Lin, John Bonham-Carter, James R. Rusche
  • Histone deacetylase inhibitors
    Patent number: 10981933
    Abstract: This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: April 20, 2021
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Vincent Jacques, James R. Rusche, Norton P. Peet, Jasbir Singh
  • HISTONE DEACETYLASE INHIBITORS
    Publication number: 20200148704
    Abstract: This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Application
    Filed: November 8, 2019
    Publication date: May 14, 2020
    Inventors: Vincent Jacques, James R. Rusche, Norton P. Peet, Jasbir Singh
  • Histone deacetylase inhibitors
    Patent number: 10526346
    Abstract: This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: January 7, 2020
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Vincent Jacques, James R. Rusche, Norton P. Peet, Jasbir Singh
  • HDAC INHIBITORS
    Publication number: 20190382351
    Abstract: Disclosed herein are compounds of formula (I), and methods of inhibiting histone deacetylase (“HDAC”) enzymes (e.g.
    Type: Application
    Filed: August 22, 2019
    Publication date: December 19, 2019
    Inventors: Vincent Jacques, James R. Rusche
  • HDAC inhibitors
    Patent number: 10428028
    Abstract: Disclosed herein are compounds of formula (I), and methods of inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3) using compounds of formula (I).
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: October 1, 2019
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Vincent Jacques, James R. Rusche
  • HISTONE DEACETYLASE INHIBITORS
    Publication number: 20190233439
    Abstract: This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Application
    Filed: March 12, 2019
    Publication date: August 1, 2019
    Inventors: Vincent Jacques, James R. Rusche, Norton P. Peet, Jasbir Singh
  • Histone deacetylase inhibitors
    Patent number: 10301323
    Abstract: This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: May 28, 2019
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Vincent Jacques, James R. Rusche, Norton P. Peet, Jasbir Singh
  • Histone deacetylase inhibitors
    Patent number: 10280182
    Abstract: This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: May 7, 2019
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Vincent Jacques, James R. Rusche, Norton P. Peet, Jasbir Singh
  • HISTONE DEACETYLASE INHIBITORS
    Publication number: 20180370987
    Abstract: This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Application
    Filed: July 26, 2018
    Publication date: December 27, 2018
    Inventors: Vincent Jacques, James R. Rusche, Norton P. Peet, Jasbir Singh
  • HDAC INHIBITORS
    Publication number: 20180362472
    Abstract: Disclosed herein are compounds of formula (I), and methods of inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3) using compounds of formula (I).
    Type: Application
    Filed: June 15, 2018
    Publication date: December 20, 2018
    Inventors: Vincent Jacques, James R. Rusche
  • HISTONE DEACETYLASE INHIBITORS
    Publication number: 20180327423
    Abstract: This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Application
    Filed: July 26, 2018
    Publication date: November 15, 2018
    Inventors: Vincent Jacques, James R. Rusche, Norton P. Peet, Jasbir Singh
  • Histone deacetylase inhibitors
    Patent number: 10059723
    Abstract: This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: August 28, 2018
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Vincent Jacques, James R. Rusche, Norton P. Peet, Jasbir Singh
  • HISTONE DEACETYLASE INHIBITORS
    Publication number: 20180208606
    Abstract: This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Application
    Filed: January 3, 2018
    Publication date: July 26, 2018
    Inventors: Vincent Jacques, James R. Rusche, Norton P. Peet, Jasbir Singh
  • HDAC inhibitors
    Patent number: 10029988
    Abstract: Disclosed herein are compounds of formula (I), and methods of inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3) using compounds of formula (I).
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: July 24, 2018
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Vincent Jacques, James R. Rusche
  • Alternating Tangential Flow Rapid Harvesting
    Publication number: 20180148677
    Abstract: Methods and systems of harvesting a cell product from a cell culture by culturing cells in a fluid medium until the cells have produced a cell product at a harvest concentration are disclosed. The cells are cultured in a cell culture system including a bioreactor connected to an ATF device. The methods include draining fluid medium from the bioreactor through the outlet and the ATF device until the bioreactor volume reaches a predetermined volume, and the ATF column yields at an ATF outlet a liquid containing cell product and passes fluid medium with a concentration of cell product that is lower than the harvest concentration back into the bioreactor, extracting the liquid containing cell product from the ATF outlet, refilling the bioreactor with sterile phosphate buffered saline or fluid medium without any cell product, and repeating steps until a desired amount of cell product has been removed.
    Type: Application
    Filed: July 25, 2017
    Publication date: May 31, 2018
    Inventors: Shashi Kiran Kudugunti, WengLong Roy Lin, John Bonham-Carter, James R. Rusche
  • Histone deacetylase inhibitors
    Patent number: 9908899
    Abstract: The compounds provided herein are phenyl analine amides and are useful for inhibiting histone deacteylase (“HDAC”) enzymes, such as HDAC1, HDAC2, and HDAC3.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: March 6, 2018
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Vincent Jacques, James R. Rusche, Norton P. Peet, Jasbir Singh
  • Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
    Patent number: 9796664
    Abstract: This invention relates to compounds of Formula (I) wherein Cy1, L1, Y, R1, L2, and Ar2 are defined herein, for the treatment of cancers, inflammatory disorders, and neurological conditions.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: October 24, 2017
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventors: James R. Rusche, Norton P. Peet, Allen Hopper
  • HISTONE DEACETYLASE INHIBITORS
    Publication number: 20170050984
    Abstract: This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Application
    Filed: November 9, 2016
    Publication date: February 23, 2017
    Inventors: Vincent Jacques, James R. Rusche, Norton P. Peet, Jasbir Singh