Patents by Inventor James R. Shroff

James R. Shroff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-Substituted 1,4-dihydropyridines and pharmaceutical compositions
    Patent number: 4500528
    Abstract: The compounds of the formula: ##STR1## wherein each of the substituents is as defined herein are useful anti-hypertensive agents.
    Type: Grant
    Filed: March 3, 1983
    Date of Patent: February 19, 1985
    Assignee: USV Pharmaceutical Corporation
    Inventors: Bernard Loev, Howard Jones, James R. Shroff
  • Antihypertensive 4[(3-alkylamino-2-hydroxypropyl)-oxyiminomethyl phenyl]-1,4-dihydropyridines
    Patent number: 4500527
    Abstract: Unsaturated heterocyclic dihydropyridines of the formula: ##STR1## wherein the substituents defined herein have been found to have useful antihypertensive activity.
    Type: Grant
    Filed: June 22, 1983
    Date of Patent: February 19, 1985
    Assignee: USV Pharmaceutical Corporation
    Inventors: Bernard Loev, James R. Shroff, Rohit Desai
  • Dihydropyridines and their use in the treatment of asthma
    Patent number: 4478834
    Abstract: New dihydropyridines are described. These compounds are useful in the treatment of asthma.
    Type: Grant
    Filed: February 11, 1983
    Date of Patent: October 23, 1984
    Assignee: USV Pharmaceutical Corporation
    Inventors: James R. Shroff, Bernard Loev
  • N-Substituted 1,4-dihydropyridazines and pharmaceutical compositions
    Patent number: 4435395
    Abstract: Compounds of the formula: ##STR1## which are useful as antihypertensive agents are disclosed.
    Type: Grant
    Filed: March 3, 1983
    Date of Patent: March 6, 1984
    Assignee: USV Pharmaceutical Corporation
    Inventors: Bernard Loev, Howard Jones, James R. Shroff
  • N-(-2-Pyrimidinyl)-4-aryl-4-[N'-(alkylamino alkyl)]-piperidinamide
    Patent number: 4329345
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen, alkyl, alkoxy, halo, amino, alkylamino, dialkylamino, hydroxy, nitro, trifluoromethyl, mercapto, or alkylmercapto, and may be the same or different,n is an integer from 2 to 4, andR.sub.1 and R.sub.2 are hydrogen or alkyl and may be the same or different, or R.sub.1 and R.sub.2 taken together with the nitrogen to which they are attached may be pyrrolidino, piperidino or morpholinoand their pharmaceutically acceptable, non-toxic acid addition salts have anti-arrhythmic activity.
    Type: Grant
    Filed: April 28, 1980
    Date of Patent: May 11, 1982
    Assignee: USV Pharmaceutical Corporation
    Inventors: James R. Shroff, Rohit Desai
  • Naphthyridone derivatives
    Patent number: 4304914
    Abstract: Compounds of the formula ##STR1## wherein each of R, R.sub.1 and R.sub.2 is independently H, alkyl, alkenyl, alkoxy, halo, hydroxy, trifluoromethyl, amino, alkylamino, cyano and nitro;R.sub.3 is carbalkoxy, carboxamide alkanoyl, trifluoromethyl and cyano; andAr is heteroaryl or ##STR2## wherein R.sub.4 and R.sub.5 have the same meaning as each of R, R.sub.1 and R.sub.2 ; and acid addition salts thereof have cardiotonic and hypertensive activity.
    Type: Grant
    Filed: July 7, 1980
    Date of Patent: December 8, 1981
    Assignee: USV Pharmaceutical Corporation
    Inventors: James R. Shroff, Bernard Loev
  • Antihypertensive amines
    Patent number: 4302591
    Abstract: Iminobenzyl dihydropyridines of the formula ##STR1## wherein, each R is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, sulfonamido, halogen, alkoxy, alkenyloxy, alkynyloxy, cyano, hydroxy, acyloxy, nitro, amino, alkylmercapto, alkylamino, alkanoylamino, carbalkoxyamino, carboxy, methanesulfonyl, carbalkoxy or trifluoromethyl;each R.sub.4 is lower alkoxy;each R.sub.2 is lower alkyl;and R.sub.3 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic or ##STR2## wherein R is as previously defined; have anti-hypertensive activity.
    Type: Grant
    Filed: September 2, 1980
    Date of Patent: November 24, 1981
    Assignee: USV Pharmaceutical Corporation
    Inventors: James R. Shroff, Bernard Loev
  • Pyridylacyl-hydroxamates
    Patent number: 4283541
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are independently hydrogen, lower alkyl, phenyl or phenyl-lower alkyl,n is an integer from 1 to 5, andm is an integer from 2 to 5 have antiarrhythmic activity.
    Type: Grant
    Filed: May 27, 1980
    Date of Patent: August 11, 1981
    Assignee: USV Pharmaceutical Corporation
    Inventors: James R. Shroff, Rohit Desai
  • Substituted benzylidene imines
    Patent number: 4264505
    Abstract: Compounds of the formula ##STR1## wherein R is lower alkyl, phenyl, lower alkenyl, cycloalkyl and substituted phenyl;R.sub.1 is hydrogen, lower alkyl, lower alkenyl, lower alkoxy, amino, lower alkylamino, hydroxy, halo, nitro, mercapto, trifluoromethyl, lower alkylmercapto, and trifluoromethylmercapto;R.sub.2, R.sub.3 are lower alkyl or taken together with N form a cyclic amine;X is O or S, andn is an integer from 2 to 4are useful in treatment of arrhythmia.
    Type: Grant
    Filed: December 26, 1979
    Date of Patent: April 28, 1981
    Assignee: USV Pharmaceutical Corporation
    Inventors: James R. Shroff, Rohit Desai
  • Antihypertensive pyridines and compositions
    Patent number: 4258042
    Abstract: Antihypertensive compounds of the formula ##STR1## wherein R.sub.5 is H, alkyl, aryl, halo, lower alkoxy, nitro amino, alkylmercapto, cyano, carboxy, carbalkoxy, sulfamyl, trifluoromethyl, hydroxy, acyloxy, methanesulfonyl, alkylamino or acylamino; and each R.sub.1 and R.sub.2 is alkyl; wherein the alkyl, alkoxy and aryl groups contain up to 10 carbon atoms and non-toxic, pharmaceutically-acceptable acid addition salts thereof.
    Type: Grant
    Filed: April 11, 1980
    Date of Patent: March 24, 1981
    Assignee: USV Pharmaceutical Corporation
    Inventors: Bernard Loev, James R. Shroff
  • Piperazinyl-imidazolines
    Patent number: 4022783
    Abstract: Compounds of the structure ##STR1## wherein R is lower alkyl or ##STR2## WHEREIN R.sub.1 and R.sub.2 are hydrogen, lower alkyl, lower alkoxy, hydroxy, amino, nitro, halogen and trifluoromethyl and may be the same or different, and m and n are integers from 0 to 1 have potent hypotensive activity.
    Type: Grant
    Filed: December 18, 1975
    Date of Patent: May 10, 1977
    Assignee: USV Pharmaceutical Corporation
    Inventors: James R. Shroff, Peter P. Cervoni