Patents by Inventor James R. Uhl

James R. Uhl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for detecting methicillin-resistant
    Patent number: 8535888
    Abstract: The present invention relates to methods of detecting the presence or absence of methicillin-resistant S. aureus (MRSA) in a sample, the method comprising performing an amplifying step, a hybridizing step and a detecting step. Furthermore, the present invention relates to primers, probes and kits for the detection of MRSA.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: September 17, 2013
    Assignees: Mayo Foundation for Medical Education and Research, Roche Molecular Systems
    Inventors: Christian Aichinger, Astrid Reiser, James R. Uhl, Franklin R. Cockerill, III
  • Detection of group B
    Patent number: 8097413
    Abstract: The invention provides methods to detect group B streptococcus (GBS) in biological samples using real-time PCR. Primers and probes for the detection of GBS are provided by the invention. Articles of manufacture containing such primers and probes for detecting GBS are further provided by the invention.
    Type: Grant
    Filed: July 26, 2010
    Date of Patent: January 17, 2012
    Assignees: Mayo Foundation for Medical Education and Research, Roche Molecular Systems
    Inventors: James R Uhl, Franklin R Cockerill, III, Christian Aichinger, Astrid Reiser
  • Detection of Group B Streptococcus
    Publication number: 20100291582
    Abstract: The invention provides methods to detect group B streptococcus (GBS) in biological samples using real-time PCR. Primers and probes for the detection of GBS are provided by the invention. Articles of manufacture containing such primers and probes for detecting GBS are further provided by the invention.
    Type: Application
    Filed: July 26, 2010
    Publication date: November 18, 2010
    Inventors: James R. Uhl, Franklin R. Cockerill, III, Christian Aichinger, Astrid Reiser
  • Detection of group B
    Patent number: 7790875
    Abstract: The invention provides methods to detect group B streptococcus (GBS) in biological samples using real-time PCR. Primers and probes for the detection of GBS are provided by the invention. Articles of manufacture containing such primers and probes for detecting GBS are further provided by the invention.
    Type: Grant
    Filed: September 23, 2008
    Date of Patent: September 7, 2010
    Assignees: Mayo Foundation for Medical Education and Research, Roche Molecular Systems, Inc.
    Inventors: James R. Uhl, Franklin R. Cockerill, III, Christian Aichinger, Astrid Reiser
  • SWAB EXTRACTION DEVICE AND METHODS OF USING
    Publication number: 20090171245
    Abstract: This disclosure describes a swab extraction device that can be used to collect a medical specimen, transport the specimen to a laboratory, and process and analyze the specimen.
    Type: Application
    Filed: May 3, 2007
    Publication date: July 2, 2009
    Inventors: James R. Uhl, Franklin R. Cockerill III, Christian Aichinger
  • Detection of Group B Streptococcus
    Publication number: 20090111111
    Abstract: The invention provides methods to detect group B streptococcus (GBS) in biological samples using real-time PCR. Primers and probes for the detection of GBS are provided by the invention. Articles of manufacture containing such primers and probes for detecting GBS are further provided by the invention.
    Type: Application
    Filed: September 23, 2008
    Publication date: April 30, 2009
    Inventors: James R. Uhl, Franklin R. Cockerill, III, Christian Aichinger, Astrid Reiser
  • Detection of group B streptococcus
    Patent number: 7427475
    Abstract: The invention provides methods to detect group B streptococcus (GBS) in biological samples using real-time PCR. Primers and probes for the detection of GBS are provided by the invention. Articles of manufacture containing such primers and probes for detecting GBS are further provided by the invention.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: September 23, 2008
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: James R. Uhl, Franklin R. Cockerill, III, Christian Aichinger, Astrid Reiser
  • COMPOSITIONS AND METHODS FOR DETECTING METHICILLIN-RESISTANT S. AUREUS
    Publication number: 20080220428
    Abstract: The present invention relates to methods of detecting the presence or absence of methicillin-resistant S. aureus (MRSA) in a sample, the method comprising performing an amplifying step, a hybridizing step and a detecting step. Furthermore, the present invention relates to primers, probes and kits for the detection of MRSA.
    Type: Application
    Filed: December 28, 2007
    Publication date: September 11, 2008
    Inventors: Christian Aichinger, Astrid Reiser, James R. Uhl, Franklin R. Cockerill
  • Detection of -containing spp.
    Patent number: 7074599
    Abstract: The invention provides methods to detect mecA-containing Staphylococcus spp. in biological samples using real-time PCR. Primers and probes for the detection of S. aureus are provided by the invention. Articles of manufacture containing such primers and probes for detecting mecA-containing Staphylococcus spp. are further provided by the invention.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: July 11, 2006
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: James R. Uhl, Franklin R. Cockerill, III
  • Detection of Legionella
    Patent number: 6830888
    Abstract: The invention provides methods to detect Legionella and further to detect L. pneumophila in biological samples using real-time PCR. Primers and probes for the detection of Legionella and L. pneumophila are provided by the invention. Articles of manufacture containing such primers and probes for detecting Legionella and L. pneumophila are further provided by the invention.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: December 14, 2004
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Franklin R. Cockerill, Randall T. Hayden, James R. Uhl
  • Detection of mecA-containing Staphylococcus spp.
    Publication number: 20040063103
    Abstract: The invention provides methods to detect mecA-containing Staphylococcus spp. in biological samples using real-time PCR. Primers and probes for the detection of S. aureus are provided by the invention. Articles of manufacture containing such primers and probes for detecting mecA-containing Staphylococcus spp. are further provided by the invention.
    Type: Application
    Filed: September 27, 2002
    Publication date: April 1, 2004
    Inventors: James R. Uhl, Franklin R. Cockerill
  • Detection of group a streptococcus
    Publication number: 20040014118
    Abstract: The invention provides methods to detect Group A Streptococcus (GAS) in biological samples using real-time PCR. Primers and probes for the detection of GAS are provided by the invention. Articles of manufacture containing such primers and probes for detecting GAS are further provided by the invention.
    Type: Application
    Filed: June 19, 2003
    Publication date: January 22, 2004
    Applicant: Mayo Foundation for Medical Education and Research , a Minnesota corporation
    Inventors: James R. Uhl, Franklin R. Cockerill
  • Detection of Shiga toxin- or Shiga-like toxin-producing organisms
    Publication number: 20030215814
    Abstract: The invention provides methods to detect Shiga toxin- or Shiga-like toxin-producing organisms, particularly Shiga-like toxin-producing E. coli organisms, in biological samples using real-time PCR. Primers and probes for the detection of Shiga toxin- or Shiga-like toxin-producing organisms are provided by the invention. Articles of manufacture containing such primers and probes for detecting Shiga toxin- or Shiga-like toxin-producing organisms are further provided by the invention.
    Type: Application
    Filed: May 17, 2002
    Publication date: November 20, 2003
    Inventors: Franklin R. Cockerill, Jon E. Rosenblatt, Lynne Sloan, James R. Uhl
  • Nucleic acid recovery reagents and methods
    Publication number: 20030215954
    Abstract: Disclosed are reagents and techniques useful for recovering nucleic acids from stool samples. The recovered nucleic acids can be used in medical and veterinary diagnostic procedures that involve nucleic acid-based detection of pathogens and tumor cells.
    Type: Application
    Filed: May 17, 2002
    Publication date: November 20, 2003
    Inventors: Franklin R. Cockerill, Jon E. Rosenblatt, Lynne Sloan, James R. Uhl
  • Swab extraction system
    Publication number: 20030157728
    Abstract: Disclosed are tools and techniques that can be used to rapidly and inexpensively obtain microorganisms from biological samples collected on swabs. The disclosed swab extraction systems and methods can speed diagnostic procedures and expedite therapeutic intervention, thereby improving patient outcomes.
    Type: Application
    Filed: February 20, 2002
    Publication date: August 21, 2003
    Inventors: James R. Uhl, Franklin R. Cockerill
  • Detection of group a Streptococcus
    Patent number: 6593093
    Abstract: The invention provides methods to detect Group A Streptococcus (GAS) in biological samples using real-time PCR. Primers and probes for the detection of GAS are provided by the invention. Articles of manufacture containing such primers and probes for detecting GAS are further provided by the invention.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: July 15, 2003
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: James R. Uhl, Franklin R. Cockerill
  • Detection of Legionella
    Publication number: 20030082577
    Abstract: The invention provides methods to detect Legionella and further to detect L. pneumophila in biological samples using real-time PCR. Primers and probes for the detection of Legionella and L. pneumophila are provided by the invention. Articles of manufacture containing such primers and probes for detecting Legionella and L. pneumophila are further provided by the invention.
    Type: Application
    Filed: May 7, 2002
    Publication date: May 1, 2003
    Inventors: Franklin R. Cockerill, Randall T. Hayden, James R. Uhl
  • Mutations in the katG gene useful for detection of M. tuberculosis
    Patent number: 5922575
    Abstract: A method for selectively detecting M. tuberculosis is provided employing restriction fragment length polymorphism analysis of an enzymatic digest of the M. tuberculosis katG gene.
    Type: Grant
    Filed: May 7, 1997
    Date of Patent: July 13, 1999
    Assignee: Mayo Foundation for Medical Education & Research
    Inventors: Franklin R. Cockerill, III, Bruce C. Kline, James R. Uhl
  • Detection of isoniazid resistent strains of M. tuberculosis
    Patent number: 5688639
    Abstract: A method for determining the susceptibility of a strain of M. tuberculosis to isoniazid is provided comprising employing the techniques of restriction length polymorphism analysis to determine whether or not the DNA of said strain has an NciI-MspI restriction site at the codon corresponding to codon 463 of an M. tuberculosis katG gene consensus sequence.
    Type: Grant
    Filed: April 18, 1994
    Date of Patent: November 18, 1997
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Franklin R. Cockerill, Bruce C. Kline, James R. Uhl
  • Detection of isoniazid resistant strains of M. tuberculosis
    Patent number: 5658733
    Abstract: A method for determining the susceptibility of a strain of M. tuberculosis to isoniazid is provided comprising employing the techniques of restriction fragment length polymorphism analysis to determine whether or not the DNA of said strain has an MspI restriction site at the codon corresponding to codons 315 or 463 of an M. tuberculosis katG gene consensus sequence.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: August 19, 1997
    Assignee: Mayo Foundation For Medical Education And Research
    Inventors: Franklin R. Cockerill, III, Bruce C. Kline, James R. Uhl