Abstract: In a multiple-lumen catheter having multiple guidewires for treatment of vascular blockages, the catheter comprising a proximal-end assembly, a distal-end portion and a multi-lumen medial portion therebetween, the improvement wherein: (1) the multiple guidewires are preloaded in the catheter, each guidewire in its own single-guidewire lumen extending from its own guidewire entry port in the proximal-end assembly to a lumen convergence portion; and (2) the distal-end portion includes: (a) the lumen convergence portion along which the multiple lumens merge into a single output lumen sized to match the largest-diameter lumen of the multiple lumens, (b) an intermediate distal-end section connected to the lumen convergence portion and surrounding the single output lumen continuing therethrough, and (c) a tapered tip surrounding the single output lumen continuing therethrough.

Abstract: A multi-lumen catheter having a guidewire for each lumen, the catheter having a proximal-end assembly and an elongate tube including a multi-lumen medial portion and a distal-end portion. Each guidewire extends from the proximal end assembly through the medial portion to a lumen convergence portion which merges the lumens into a single output lumen. The distal-end portion includes (a) the lumen convergence portion, (b) an intermediate section surrounding the output lumen, and (c) a tapered tip surrounding the output lumen, with the diameter of each lumen of the multiple lumens other than the output lumen being sized to match the guidewire therein such that the guidewire is able to move therealong while being constrained laterally and remaining substantially coaxial with its lumen, and the diameter of the single output lumen being equal to the diameter of the largest diameter lumen of the multiple lumens.

Abstract: A prosthetic implant including an anchor member; at least one resilient tethering strut extending from the anchor member; a coaptation structure coupled to an end of the at least one resilient tethering strut; and a tensioning unit extending between the anchor member and the coaptation structure. The tensioning unit including a flexible hollow tubing, and a tensioning wire extending therethrough with a first end of the tensioning wire fixed at a junction between a first end of the flexible hollow tubing and the coaptation structure and with a second end of the tensioning wire extending out from a second end of the flexible hollow tubing. The second end of the tensioning wire being pullable away from the second end of the flexible hollow tubing to bend the flexible hollow tubing and the at least one resilient tethering strut to move the coaptation structure relative to the anchor member.

Abstract: A coaxial multilumen annulus plane catheter, including an outer pigtail catheter enclosing one or two additional lumens, each housing either a slidable shaped wire or a second pigtail catheter shaped to fit into a wide range of annulus diameters and/or depths. In embodiments, the device may include a catheter delivery handle with thumb/finger-actuated sliders that extend or retract the shaped wires and are sized to enable side-to-side or radial motion, imparting a torque to the pre-shaped wires which translates the length of the wires to enable individually controlled rotation or sweep of each wire to accommodate different annulus diameters. The delivery handle includes hemostasis controls and flush ports. In other embodiments, a handle is obviated by direct lumen axial and rotational control at a proximal end.

Abstract: In a multiple-lumen catheter having multiple guidewires for treatment of vascular blockages, the catheter comprising a proximal-end assembly, a distal-end portion and a multi-lumen medial portion therebetween, the improvement wherein: (1) the multiple guidewires are preloaded in the catheter, each guidewire in its own single-guidewire lumen extending from its own guidewire entry port in the proximal-end assembly to a lumen convergence portion; and (2) the distal-end portion includes: (a) the lumen convergence portion along which the multiple lumens merge into a single output lumen sized to match the largest-diameter lumen of the multiple lumens, (b) an intermediate distal-end section connected to the lumen convergence portion and surrounding the single output lumen continuing therethrough, and (c) a tapered tip surrounding the single output lumen continuing therethrough.

Abstract: A coaxial multilumen annulus plane catheter, including an outer pigtail catheter enclosing one or two additional lumens, each housing either a slidable shaped wire or a second pigtail catheter shaped to fit into a wide range of annulus diameters and/or depths. In embodiments, the device may include a catheter delivery handle with thumb/finger-actuated sliders that extend or retract the shaped wires and are sized to enable side-to-side or radial motion, imparting a torque to the pre-shaped wires which translates the length of the wires to enable individually controlled rotation or sweep of each wire to accommodate different annulus diameters. The delivery handle includes hemostasis controls and flush ports. In other embodiments, a handle is obviated by direct lumen axial and rotational control at a proximal end.

Abstract: A general-purpose approach to solving the core problems of detecting and predicting the actions of invisible actors, and the consequential challenges of intervention and prevention. The operational forecasting system is applied to data gathered from complex systems. The operational forecasting system uses novel early-warning signals that are based on anomalous behaviors of actors/agents that are observed, as they respond to those unobserved actors that are the source of systemic change. The operational forecasting system targets predicting when an event will occur, before it does, based on the anomalous behaviors of observed actors responding to those invisible actors that are creating the perturbation (i.e. the murmuration).

Abstract: Some embodiments relate in part to endovascular prostheses and methods of deploying same. Embodiments may be directed more specifically to stent grafts and methods of making and deploying same within the body of a patient. Stent embodiments may include tapered struts for an even distribution of strain. Stent embodiments may also include portions which are enlarged in a circumferential direction which may be configured to stabilize the stent in a constrained state.

Abstract: A valve implant includes a valve leaflet prosthesis having a wire frame, a leaflet blade panel attached to the wire frame, and one or more tether struts extending from the wire frame, and a stent having a first end portion and a second end portion along a longitudinal stent axis, and a flexible extended stent strut extending longitudinally from the first end portion, wherein the one or more tether struts of the valve leaflet prosthesis is rotatably coupled to the flexible extended stent strut in a manner such that the one or more tether struts are rotatable about a rotational axis which is parallel to the one or more tether struts and which extends transverse to the longitudinal stent axis. A delivery system for the valve implant and a method of preparing the delivery system are also disclosed.

Abstract: Some embodiments relate in part to endovascular prostheses and methods of deploying same. Embodiments may be directed more specifically to stent grafts and methods of making and deploying same within the body of a patient. Stent embodiments may include tapered struts for an even distribution of strain. Stent embodiments may also include portions which are enlarged in a circumferential direction which may be configured to stabilize the stent in a constrained state.

Abstract: Some embodiments relate in part to endovascular prostheses and delivery catheter systems and methods for deploying same. Embodiments may be directed more specifically to graft bodies having self-expanding members, including inflatable graft bodies, and catheters and methods for deploying same within the body of a patient.

Abstract: Some embodiments relate in part to endovascular prostheses and delivery catheter systems and methods for deploying same. Embodiments may be directed more specifically to graft bodies having self-expanding members, including inflatable graft bodies, and catheters and methods for deploying same within the body of a patient.

Abstract: Embodiments are directed in part to endovascular prostheses and methods of deploying same. Embodiments may be directed more specifically to stent grafts and methods of positioning and deploying such devices within the body of a patient.

Abstract: Embodiments are directed in part to endovascular prostheses and methods of deploying same. Embodiments may be directed more specifically to stent grafts and methods of positioning and deploying such devices within the body of a patient.

Abstract: A surgical stereoscopic visualization system having a microscope head, dual cameras mounted on or proximate the microscope head for real time video capture of a subject in an operative field, a video processing and display system to receive separate video streams from the cameras and to combine the separate video streams into a time-aligned stereoscopic image. The processed image is displayed on a matrix display screen in at least one movable head-mounted stereoscopic display. Movement of the head mounted display is accomplished with a support structure on a headband that accurately positions the display screen in front of the user's eyes, yet allows the user to precisely move the display screen either manually or by motorized means into and out of the user's line of sight, thereby facilitating uninterrupted use of the hands while working in the surgical suite.

Abstract: A coaxial multilumen annulus plane catheter, including an outer pigtail catheter enclosing one or two additional lumens, each housing either a slidable shaped wire or a second pigtail catheter shaped to fit into a wide range of annulus diameters and/or depths. In embodiments, the device may include a catheter delivery handle with thumb/finger-actuated sliders that extend or retract the shaped wires and are sized to enable side-to-side or radial motion, imparting a torque to the pre-shaped wires which translates the length of the wires to enable individually controlled rotation or sweep of each wire to accommodate different annulus diameters. The delivery handle includes hemostasis controls and flush ports. In other embodiments, a handle is obviated by direct lumen axial and rotational control at a proximal end.

Abstract: Presented herein are selective data content sharing techniques that enable multiple data content windows displayed at a computing device to be separately displayed within a teleconferencing system. In one example, a content analyzer server of a teleconferencing system receives a request from a computing device connected to a local teleconference endpoint to initiate selective data content sharing. The content analyzer server is configured to identify a plurality of data content windows displayed at the computing device for selective sharing at separate displays of the local teleconference endpoint and at separate displays of one or more remote teleconferencing endpoints. The content analyzer server is further configured to split a data content stream originating at the computing device into a plurality of separate data content streams, wherein each data content window identified for selective sharing has an associated separate data content stream.

Abstract: A surgical stereoscopic visualization system having a microscope head, dual cameras mounted on or proximate the microscope head for real time video capture of a subject in an operative field, a video processing and display system to receive separate video streams from the cameras and to combine the separate video streams into a time-aligned stereoscopic image. The processed image is displayed on a matrix display screen in at least one movable head-mounted stereoscopic display. Movement of the head mounted display is accomplished with a support structure on a headband that accurately positions the display screen in front of the user's eyes, yet allows the user to precisely move the display screen either manually or by motorized means into and out of the user's line of sight, thereby facilitating uninterrupted use of the hands while working in the surgical suite.

Abstract: Some embodiments relate in part to endovascular prostheses and delivery catheter systems and methods for deploying same. Embodiments may be directed more specifically to graft bodies having self-expanding members, including inflatable graft bodies, and catheters and methods for deploying same within the body of a patient.

Abstract: A steerable catheter sheath for use in directing a catheter into a desired position is provided. The sheath includes an elongated member configured to receive the catheter therein. The distal end of the elongated member is steerable in two directions, each direction having a different bent configuration, e.g., a sharp curve in one direction and an open arching curve in the other direction. A resilient structure having different bending properties in each of its lateral sides is carried in the distal portion of the elongated member and causes the asymmetric bending. In one embodiment, the resilient structure includes a hypotube with a plurality of notches and slits in the sides. In another embodiment, the resilient structure is covered in an outer coating having different durometer portions. The sheath is particularly useful for accessing left and right pulmonary veins when a transeptal entry approach is used into the left atrium.