Abstract: The present disclosure relates to somatic mutation determinations. An example method includes performing whole genome sequencing using a high-throughput sequencing system on nucleic acids from a sample obtained from a subject to generate raw data, transmitting the raw data from the high-throughput sequencing system to a computing system, processing the raw data by the computing system to generate candidate variants and a set of feature values for each candidate variant of the candidate variants, processing the feature values by the computing system using a trained machine learning model to identify somatic mutations from the candidate variants, transmitting results based on the somatic mutations from the computing system to an end device, and displaying a report on the end device based on the results.

Abstract: The present disclosure pertains to techniques that leverage machine learning models to identify tumor-specific mutations through an integrated analysis of next generation sequencing data. In a particular aspect, a computer-implemented method is provided that includes generating sequence reads from one or more samples collected from the same patient, generating variant call files by analyzing the sequence reads corresponding respectively to the one or more samples, comparing variant call files to generate a list of candidate somatic variants, generating, by a classification machine learning model, scores for each of the candidate somatic variants in the list of candidate somatic variants, where the scores are generated based on a plurality of classifications generated by the classification machine learning model, determining, based on the scores, a ctDNA status for the patient, where the ctDNA status is either positive or negative, and generating a report that provides the ctDNA status for the patient.

Abstract: Provided is a flexible light emitting semiconductor device, such as an LED device, that includes a flexible dielectric layer having first and second major surfaces with a conductive layer on the first major surface and at least one cavity in the first major surface with a conductive layer in the cavity that supports a light emitting semiconductor device. The conductive layer in the cavity is electrically isolated from the second major surface of the dielectric layer.

Abstract: Provided is a flexible light emitting semiconductor device (26), such as an LED device, that includes a flexible dielectric layer (12) having first and second major surfaces and at least one via (10) extending through the dielectric layer from the first to the second major surface, with a conductive layer (19, 20, 18) on each of the first and second major surfaces and in the via. The conductive layer (18) in the via supports a light emitting semiconductor device (26) and is electrically isolated from the conductive layer (19) on the first major surface of the dielectric layer.

Abstract: Means for identification and comparative analysis of sequence features in metagenomic whole-genome shotgun (WGS) sequence data associated with particular disease states in a subject is disclosed, along with diagnostic methods for distinguishing between different types of inflammatory bowel disease in a subject based on the microbial community signature of the subject.

Abstract: Described is a miniature tunable filter, comprising at least two adjacent coaxial-type resonators coupled to one another. Each coaxial-type resonator comprises a metal-coated ceramic dielectric cavity having a tuning rod passage formed therethrough. A tuning rod is inserted through the tuning rod passage, such that the miniature tunable filter is tuned by moving the tuning rod into and out of the tuning rod passage of the ceramic dielectric cavity. A low impedance coaxial section surrounds at least a portion of the tuning rod to create an effective microwave short-circuit at a resonant frequency of the miniature tunable filter, which results in very wide tuning and low insertion loss. In a desired aspect, the tuning rod is a solid metal tuning rod. The combination of a solid metal tuning rod with a ceramic coaxial-type resonator results in high radio frequency power handling.

Abstract: A device and method for adjusting dosage of a fuel additive is described. The device includes a fuel reservoir and an additive reservoir. A variable-flow pump is used to pump the additive into contact with the fuel to create a combined fluid. An ESR sensor is positioned downstream from the pump and fuel reservoir such that a portion of the combined fluid passes through the ESR sensor, which measures the concentration of contaminants and fuel additive in the fuel. Based on the concentrations, a controller controls the rate at which the fuel additive is pumped, thereby adjusting the dosage of the fuel additive.

Abstract: A method of and miniaturized apparatus adapted for in-situ measurement of degradation of automotive fluids and the like by micro-electron spin resonance (ESR) spectrometry, wherein the use of a modulated constant magnetic field in an RF resonating variable frequency microwave cavity resonator through which a fluid sample is passed, enables direct detection of molecular changes in such fluid sample resulting from fluid degradation during use.

Abstract: Described is an electron spin resonance (ESR) spectrometer comprising a miniaturized radio-frequency (RF) microwave cavity resonator. The miniaturized RF microwave cavity resonator receives a carrier signal from a circulator, modulates the signal path signal, and reflects the carrier signal back to the circulator to amplify the carrier signal prior to demodulation. A mixer receives and demodulates the carrier signal and outputs an audio signal to generate an ESR spectrum for analyzing a chemical composition of a fluid sample. The ESR spectrum represents a magnetic susceptibility of the fluid sample to a magnetic resonance cause variation in a resonant frequency of the miniaturized RF microwave cavity resonator. In a desired aspect, the carrier signal is split into two paths prior to demodulation. The two paths are demodulated by different mixers to produce two separate outputs, an absorption spectrum and a dispersion spectrum.

Abstract: Provided is a flexible light emitting semiconductor device (26), such as an LED device, that includes a flexible dielectric layer (12) having first and second major surfaces and at least one via (10) extending through the dielectric layer from the first to the second major surface, with a conductive layer (19, 20, 18) on each of the first and second major surfaces and in the via. The conductive layer (18) in the via supports a light emitting semiconductor device (26) and is electrically isolated from the conductive layer (19) on the first major surface of the dielectric layer.

Abstract: A process for making packer elements for use in sealing an area between surfaces in a wellbore and packer elements formed from that process. The process includes extruding an elastomeric material to form a tubular structure and machining the outer surface of the tubular structure to provide a desired surface geometry. The tubular structure may be machined to provide a contoured surface geometry. The tubular structure with a contoured surface geometry may be machined to form a plurality of packer elements, which are separated by cutting the tubular structure.

Abstract: Provided is a flexible light emitting semiconductor device, such as an LED device, that includes a flexible dielectric layer having first and second major surfaces with a conductive layer on the first major surface and at least one cavity in the first major surface with a conductive layer in the cavity that supports a light emitting semiconductor device. The conductive layer in the cavity is electrically isolated from the second major surface of the dielectric layer.

Abstract: A method of and miniaturized apparatus adapted for in-situ measurement of degradation of automotive fluids and the like by micro-electron spin resonance (ESR) spectrometry, wherein the use of a modulated constant magnetic field in an RF resonating variable frequency microwave cavity resonator through which a fluid sample is passed, enables direct detection of molecular changes in such fluid sample resulting from fluid degradation during use.

Abstract: A method of and miniaturized apparatus adapted for in-situ measurement of degradation of automotive fluids and the like by micro-electron spin resonance (ESR) spectrometry, wherein the use of a modulated constant magnetic field in an RF resonating variable frequency microwave cavity resonator through which a fluid sample is passed, enables direct detection of molecular changes in such fluid sample resulting from fluid degradation during use.

Abstract: A method for connecting circuit boards, comprising: (i) preparing a first circuit board having connection parts assigned to end parts of a plurality of conductor wirings, and a second circuit board having connection parts assigned to corresponding end parts of a plurality of conductor wirings; (ii) disposing the connection parts of the first circuit board to face the connection parts of the second circuit board with a thermosetting adhesive film between the connection parts of the circuit boards; and (iii) applying heat and pressure to the connection parts and to the thermosetting adhesive film sufficiently high to thoroughly push away the adhesive film so as to establish electrical contact between connection parts of the circuit boards facing each other and to allow for curing of the adhesive; wherein the conductor wirings constituting the connection parts of at least one of the first and second circuit boards contain non-linear wirings.

Abstract: The invention provides methods of manufacturing toric lenses, apparatuses useful in the method of the invention, and lenses produced according to the method in which method the position of one mold half in relation to its complementary mold half is more precisely controlled so that tilting and rotation of the mold halves in relation to each other is substantially eliminated.

Abstract: A method of and miniaturized apparatus adapted for in-situ measurement of degradation of automotive fluids and the like by micro-electron spin resonance (ESR) spectrometry, wherein the use of a modulated constant magnetic field in an RF resonating variable frequency microwave cavity resonator through which a fluid sample is passed, enables direct detection of molecular changes in such fluid sample resulting from fluid degradation during use.

Abstract: A method for connecting circuit boards, comprising: (i) preparing a first circuit board having connection parts assigned to end parts of a plurality of conductor wirings, and a second circuit board having connection parts assigned to corresponding end parts of a plurality of conductor wirings; (ii) disposing the connection parts of the first circuit board to face the connection parts of the second circuit board with a thermosetting adhesive film between the connection parts of the circuit boards; and (iii) applying heat and pressure to the connection parts and to the thermosetting adhesive film sufficiently high to thoroughly push away the adhesive film so as to establish electrical contact between connection parts of the circuit boards facing each other and to allow for curing of the adhesive; wherein the conductor wirings constituting the connection parts of at least one of the first and second circuit boards contain non-linear wirings.

Abstract: A process for making packer elements for use in sealing an area between surfaces in a wellbore and packer elements formed from that process. The process includes extruding an elastomeric material to form a tubular structure and machining the outer surface of the tubular structure to provide a desired surface geometry. The tubular structure may be machined to provide a contoured surface geometry. The tubular structure with a contoured surface geometry may be machined to form a plurality of packer elements, which are separated by cutting the tubular structure.

Abstract: The invention provides methods of manufacturing toric lenses, apparatuses useful in the method of the invention, and lenses produced according to the method in which method the position of one mold half in relation to its complementary mold half is more precisely controlled so that tilting and rotation of the mold halves in relation to each other is substantially eliminated.