Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

Abstract: The present disclosure generally relates to systems, methods, and computer-readable media for training and implementing an audit generation model in connection with a collection of documents or other searchable content items available across a variety of platforms. In particular, systems disclosed herein receive a search query including one or more search elements for selectively identifying relevant documents from a larger collection of documents. The system can additionally identify portions of the documents responsive to the search query and generate a query result including the identified portions of documents and selectable user interface elements associated with the query result(s). The system can further provide the query result for presentation on a client device. The system can use an audit generation model to receive feedback for the query result(s) and utilize the feedback for tuning or further training the audit generation model.

Abstract: A multi-compartment modular cooler comprising multiple fully enclosed environments, including an insulated cold storage environment, a dry storage environment and an adjustable storage environment that may be either heated or cold storage. The fully enclosed environments may separate into self-contained individual containers. Each of the separate, self-contained enclosures may also recombine into a single unit, simplifying transportation of each section. Connection and disconnection of each section of the cooler may be facilitated by interfacing a plurality of pillars extending from a bottom surface of the upper section into one or more cup holder wells molded into the lid enclosing a lid of the lower section. The depth of the cup holder wells and the length of each pillar being inserted into the cup holder wells may provide significant stability for maintaining the upper section of the multi-compartment cooler in position while connected to the upper section.

Abstract: A multi-compartment modular cooler comprising multiple fully enclosed environments, including an insulated cold storage environment, a dry storage environment and an adjustable storage environment that may be either heated or cold storage. The fully enclosed environments may separate into self-contained individual containers. Each of the separate, self-contained enclosures may also recombine into a single unit, simplifying transportation of each section. Connection and disconnection of each section of the cooler may be facilitated by interfacing a plurality of pillars extending from a bottom surface of the upper section into one or more cup holder wells molded into the lid enclosing a lid of the lower section. The depth of the cup holder wells and the length of each pillar being inserted into the cup holder wells may provide significant stability for maintaining the upper section of the multi-compartment cooler in position while connected to the upper section.

Abstract: The present invention is an oro-fiberscopic biteblock. The biteblock is utilized during oral fiberscopic procedures. The biteblock includes a main structure having an orifice sized to accommodate entry of a fiberscope, such as an endoscope, through the orifice. The biteblock includes an extension extending inward from the main structure when positioned within the mouth of a patient. On each side of the orifice is a loop for handling and positioning the biteblock within the patient's mouth. The biteblock includes an exhalation tube running from the extension to a monitoring device which allows monitoring of the patient's expelled gases. In addition, an inhalation tube may be used to provide supplemental oxygen to the patient. The biteblock is positioned in the mouth of the patient with the mouth of the patient surrounding the extension. The tubes include openings which are located on the extension and lie in the interior of the mouth to provide monitoring of uncontaminated gasses expelled by the patient.

Abstract: Precut, production blank components can be folded manually to form a birdhouse without the need for tools or other aids in assembly, even where the blank components are manufactured from metal, rigid plastic or the like. The precut blank components include a one-piece main panel and a detached panel. The one-piece panel includes a rear section, a base section, first and second side sections, and a top section. Each section includes precut slots, tabs and hinges that act as folding guides, allowing the blank to easily fold into a structure defining an enclosure like the birdhouse. The detached panel then is mounted to the so constructed main panel to cover the enclosure and thereby complete the birdhouse.