Abstract: Systems and methods for a sterile imaging protective system are described. The system preferably includes a first flexible drape with a cavity configured to surround an imaging intensifier and a second drape that is attached to an operating table or patient drape. The second drape has a proximal portion, a distal portion, a pocket therebetween with a top sterile portion and a lower portion, and a plurality of reusable fasteners that allows the second drape to be repeatedly moved from a collapsed configuration to an expanded configuration. When in the expanded configuration, the second drape is releasably attached to the first drape. The system may also include a third drape located on the opposite side of the operating table as the second drape. The drapes preferably allow sterility to be maintained during movement of the c-arm imaging system.