Patents by Inventor James Robert Knight

James Robert Knight has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification and comparison of protein—protein interactions that occur in populations and identification of inhibitors of these interactors
    Patent number: 6410239
    Abstract: Methods are described for detecting protein-protein interactions, among two populations of proteins, each having a complexity of at least 100. Encoded proteins are fused either to the DNA-binding domain of a transcriptional activator or to the activation domain of a transcriptional activator. Two yeast strains, of the opposite mating type and carrying one type each of the fusion proteins are mated together. Productive interactions between the two halves due to protein-protein interactions lead to the reconstitution of the transcriptional activator, which in turn leads to the activation of a reporter gene containing a binding site for the DNA-binding domain. This analysis can be carried out for two or more populations of proteins.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: June 25, 2002
    Assignee: CuraGen Corporation
    Inventors: Krishnan Nandabalan, Jonathan Marc Rothberg, Meijia Yang, James Robert Knight, Theodore Samuel Kalbfleisch
  • Identification and comparison of protein-protein interactions that occur in populations and identification of inhibitors of these interactors
    Patent number: 6057101
    Abstract: Methods are described for detecting protein-protein interactions, among two populations of proteins, each having a complexity of at least 1,000. For example, proteins are fused either to the DNA-binding domain of a transcriptional activator or to the activation domain of a transcriptional activator. Two yeast strains, of the opposite mating type and carrying one type each of the fusion proteins are mated together. Productive interactions between the two halves due to protein-protein interactions lead to the reconstitution of the transcriptional activator, which in turn leads to the activation of a reporter gene containing a binding site for the DNA-binding domain. This analysis can be carried out for two or more populations of proteins.
    Type: Grant
    Filed: June 13, 1997
    Date of Patent: May 2, 2000
    Assignee: CuraGen Corporation
    Inventors: Krishnan Nandabalan, Jonathan Marc Rothberg, Meijia Yang, James Robert Knight, Theodore Samuel Kalbfleisch