Abstract: Described is an extraction device for extracting compounds from plant material and a method for using such an extraction device. The extraction device comprises an extraction tank receiving plant material and dissolving soluble compounds inside the plant material into a solvent to form a micelle. A series of fluidly connected separation chambers separate purified compounds from the micelle, resulting in purified compounds in each of the separation chambers and solvent. A heat exchanger and a chilled reservoir are used for cooling and storing the solvent. A pump is used for pumping and circulating the solvent into the extraction device. Finally, a control system automatically controls temperature and flow in the extraction device.

Abstract: Described is an extraction device for extracting compounds from plant material and a method for using such an extraction device. The extraction device comprises an extraction tank receiving plant material and dissolving soluble compounds inside the plant material into a solvent to form a micelle. A series of fluidly connected separation chambers separate purified compounds from the micelle, resulting in purified compounds in each of the separation chambers and solvent. A heat exchanger and a chilled reservoir are used for cooling and storing the solvent. A pump is used for pumping and circulating the solvent into the extraction device. Finally, a control system automatically controls temperature and flow in the extraction device.

Abstract: Cancer immunology provides promising new avenues for cancer treatment but validation of potential neoantigens to target is costly and expensive. Analysis of MHC binding affinity, antigen processing, similarity to known antigens, predicted expression levels (as mRNA or proteins), self-similarity, and mutant allele frequency, provides screening method to identify and prioritize candidate neoantigens using sequencing data. Methods of the invention thereby save time and money by identifying the priority candidate neoantigens for further experimental validation.

Abstract: Cancer immunology provides promising new avenues for cancer treatment but validation of potential neoantigens to target is costly and expensive. Analysis of MHC binding affinity, antigen processing, similarity to known antigens, predicted expression levels (as mRNA or proteins), self-similarity, and mutant allele frequency, provides screening method to identify and prioritize candidate neoantigens using sequencing data. Methods of the invention thereby save time and money by identifying the priority candidate neoantigens for further experimental validation.

Abstract: The inventive subject matter relates broadly to novel techniques for identification and comparative analysis of sequence features in metagenomic whole-genome shotgun (WGS) sequence data associated with particular disease states in a subject. More particularly, the inventive subject matter relates to diagnostic methods for distinguishing between different types of inflammatory bowel disease in a subject based on the microbial community signature of the subject.

Abstract: Cancer immunology provides promising new avenues for cancer treatment but validation of potential neoantigens to target is costly and expensive. Analysis of MHC binding affinity, antigen processing, similarity to known antigens, predicted expression levels (as mRNA or proteins), self-similarity, and mutant allele frequency, provides screening method to identify and prioritize candidate neoantigens using sequencing data. Methods of the invention thereby save time and money by identifying the priority candidate neoantigens for further experimental validation.

Abstract: An instrument and method using electron spin resonance spectrometry for measuring the concentration of airborne soot particles, and the like, that includes continuously passing a sample of exhaust gas through a resonating RF microwave cavity resonator during the application therethrough of a uniform slowly varying uniform magnetic field that is rapidly modulated and measuring the resulting phase modulation or amplitude modulation thereof to derive an electron spin resonance signal that directly senses the concentration of carbon free radicals produced as a result of inefficient combustion of hydrocarbons during operation of the vehicle or boiler. A further invention is the use of this signal for feedback control of the engine or boiler operating parameters to minimize or substantially eliminate particulate matter emissions.

Abstract: Described is a method and system that facilitates triage of thousands to millions of potential patients within a relatively short period of time by scanning of a substrate of a designated card issued to a victim. The method and the system comprise a plurality of noninvasive self-testing test devices located at a plurality of remote peripheral self-testing sites, and each one of the plurality of noninvasive self-testing test devices facilitates self-testing of the substrate of the designated card. Each of the plurality of noninvasive self-testing test devices provides test results of the scan of the substrate of the designated card, and the potential patients are identified, then subsequently screened and triaged based upon the test results of the scan of the substrate of the designated card.

Abstract: Described is a method and system that facilitates triage of thousands to millions of potential patients within a relatively short period of time by scanning of a substrate of a designated card issued to a victim. The method and the system comprise a plurality of noninvasive self-testing test devices located at a plurality of remote peripheral self-testing sites, and each one of the plurality of noninvasive self-testing test devices facilitates self-testing of the substrate of the designated card. Each of the plurality of noninvasive self-testing test devices provides test results of the scan of the substrate of the designated card, and the potential patients are identified, then subsequently screened and triaged based upon the test results of the scan of the substrate of the designated card.

Abstract: Described is a method and system that facilitates triage of thousands to millions of potential patients within a relatively short period of time by scanning of a substrate of a designated card issued to a victim. The method and the system comprise a plurality of noninvasive self-testing test devices located at a plurality of remote peripheral self-testing sites, and each one of the plurality of noninvasive self-testing test devices facilitates self-testing of the substrate of the designated card. Each of the plurality of noninvasive self-testing test devices provides test results of the scan of the substrate of the designated card, and the potential patients are identified, then subsequently screened and triaged based upon the test results of the scan of the substrate of the designated card.

Abstract: A flow diverter device includes a valve body component defining therein two inlet channels and an outlet channel; and a rotatable diverter component comprising an exterior side wall and defining therein a connecting channel in the form of an annular slot positioned around a portion of the exterior side wall. The rotatable diverter component is rotatably received by the valve body component and being movable between a first position where the connecting channel fluidly connects one of the inlet channels with the outlet channel only and a second position where the connecting channel fluidly connects the other of the inlet channels with the outlet channel only.

Abstract: A water filter assembly is provided. The water filter assembly includes a manifold and a fitting rotatably mounted to the manifold such that the fitting is rotatable between a substantially vertical configuration and a substantially horizontal configuration. The water filter assembly also includes a diverting member and a handle mounted to the diverting member. The handle is positioned opposite the fitting on the manifold.

Abstract: Described is a method and system that facilitates triage of thousands to millions of potential patients within a relatively short period of time by scanning of a substrate of a designated card issued to a victim. The method and the system comprise a plurality of noninvasive self-testing test devices located at a plurality of remote peripheral self-testing sites, and each one of the plurality of noninvasive self-testing test devices facilitates self-testing of the substrate of the designated card. Each of the plurality of noninvasive self-testing test devices provides test results of the scan of the substrate of the designated card, and the potential patients are identified, then subsequently screened and triaged based upon the test results of the scan of the substrate of the designated card.

Abstract: The present subject matter provides a drain line adapter. The drain line adapter includes at least two conduits. The two conduits can be oriented or positioned relative to one another in order to facilitate drainage of the drain line adapter. The two conduits can also be oriented or positioned relative to one another in order to hinder clogging of the drain line assembly.

Abstract: A flow diverter device includes a valve body component defining therein two inlet channels and an outlet channel; and a rotatable diverter component comprising an exterior side wall and defining therein a connecting channel in the form of an annular slot positioned around a portion of the exterior side wall. The rotatable diverter component is rotatably received by the valve body component and being movable between a first position where the connecting channel fluidly connects one of the inlet channels with the outlet channel only and a second position where the connecting channel fluidly connects the other of the inlet channels with the outlet channel only.

Abstract: The present subject matter provides a drain line adapter. The drain line adapter includes at least two conduits. The two conduits can be oriented or positioned relative to one another in order to facilitate drainage of the drain line adapter. The two conduits can also be oriented or positioned relative to one another in order to hinder clogging of the drain line assembly.

Abstract: An instrument and method using electron spin resonance spectrometry for measuring the concentration of airborne soot particles, and the like, that includes continuously passing a sample of exhaust gas through a resonating RF microwave cavity resonator during the application therethrough of a uniform slowly varying uniform magnetic field that is rapidly modulated and measuring the resulting phase modulation or amplitude modulation thereof to derive an electron spin resonance signal that directly senses the concentration of carbon free radicals produced as a result of inefficient combustion of hydrocarbons during operation of the vehicle or boiler. A further invention is the use of this signal for feedback control of the engine or boiler operating parameters to minimize or substantially eliminate particulate matter emissions.

Abstract: An instrument and method using electron spin resonance spectrometry for measuring the concentration of airborne soot particles, and the like, that includes continuously passing a sample of exhaust gas through a resonating RF microwave cavity resonator during the application therethrough of a uniform slowly varying uniform magnetic field that is rapidly modulated and measuring the resulting phase modulation or amplitude modulation thereof to derive an electron spin resonance signal that directly senses the concentration of carbon free radicals produced as a result of inefficient combustion of hydrocarbons during operation of the vehicle or boiler. A further invention is the use of this signal for feedback control of the engine or boiler operating parameters to minimize or substantially eliminate particulate matter emissions.

Abstract: An instrument and method using electron spin resonance spectrometry for measuring the concentration of airborne soot particles, and the like, that includes continuously passing a sample of exhaust gas through a resonating RF microwave cavity resonator during the application therethrough of a uniform slowly varying uniform magnetic field that is rapidly modulated and measuring the resulting phase modulation or amplitude modulation thereof to derive an electron spin resonance signal that directly senses the concentration of carbon free radicals produced as a result of inefficient combustion of hydrocarbons during operation of the vehicle or boiler. A further invention is the use of this signal for feedback control of the engine or boiler operating parameters to minimize or substantially eliminate particulate matter emissions.

Abstract: A circuit component has an elastically deformable first structure, a second structure, and a support structure coupling the first and second structures, wherein the first structure can be variably deformed in response to a variable force, to provide either a variable capacitor or a variable tank circuit having a variable capacitor and an inductor. In one particular embodiment, a piezoelectric element is laminated to the surface of the first elastically deformable structure thereby providing the capability to deform the first structure. A method of making a circuit component includes forming an elastically deformable first structure, forming a second structure, and joining the first and second structures, to provide either a variable capacitor or a variable tank circuit having a variable capacitor and an inductor.