Patents by Inventor James Robert Zeller
James Robert Zeller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10906892Abstract: Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.Type: GrantFiled: January 15, 2019Date of Patent: February 2, 2021Assignee: NOVARTIS PHARMACEUTICALS CORPORATIONInventors: James Robert Zeller, Sripathy Venkatraman, Elisabeth C. A. Brot, Subashree Iyer, Michael Hall
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Publication number: 20190382389Abstract: Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.Type: ApplicationFiled: January 15, 2019Publication date: December 19, 2019Applicant: SARcode Bioscience Inc.Inventors: James Robert Zeller, Sripathy Venkatraman, Elisabeth C.A. Brot, Subashree Iyer, Michael Hall
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Patent number: 10214517Abstract: Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.Type: GrantFiled: June 13, 2017Date of Patent: February 26, 2019Assignee: SARCODE BIOSCIENCE INC.Inventors: James Robert Zeller, Sripathy Venkatraman, Elisabeth C. A. Brot, Subashree Iyer, Michael Hall
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Publication number: 20180118726Abstract: Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.Type: ApplicationFiled: June 13, 2017Publication date: May 3, 2018Applicant: SARcode Bioscience Inc.Inventors: James Robert ZELLER, Sripathy VENKATRAMAN, Elisabeth C. A. BROT, Subashree IYER, Michael HALL
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Patent number: 9708303Abstract: Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.Type: GrantFiled: June 23, 2015Date of Patent: July 18, 2017Assignee: SARCODE BIOSCIENCE INC.Inventors: James Robert Zeller, Sripathy Venkatraman, Elisabeth C. A. Brot, Subashree Iyer, Michael Hall
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Patent number: 9458188Abstract: A new method for the synthesis of L-Glutamyl-?-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido)butanamido)pentanedioic acid, 1 are provided. Also provided is an efficient method for the isolation and purification of the trisodium salt of the abovementioned acid, 2, in a form suitable for long term storage and use in a parenteral dosing form.Type: GrantFiled: December 19, 2011Date of Patent: October 4, 2016Assignee: BTG INTERNATIONAL LIMITEDInventors: James Alan Kerschen, Alexander James Bridges, Milind D. Choubal, Sean Mark Dalziel, Thomas Elliott Jacks, Andrew S. Thompson, James Robert Zeller
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Publication number: 20150336939Abstract: Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.Type: ApplicationFiled: June 23, 2015Publication date: November 26, 2015Applicant: SARCODE BIOSCIENCE INC.Inventors: James Robert ZELLER, Sripathy VENKATRAMAN, Elisabeth C. A. BROT, Subashree IYER, Michael HALL
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Patent number: 9085553Abstract: Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.Type: GrantFiled: July 25, 2013Date of Patent: July 21, 2015Assignee: SARCODE BIOSCIENCE, INC.Inventors: James Robert Zeller, Sripathy Venkatraman, Elisabeth C. A. Brot, Subashree Iyer, Michael Hall
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Patent number: 8809526Abstract: A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N—{N-{4-[N-((6S)-2 -hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2 -ynyl)amino]benzoyl}-L-?-glutamyl}-D-glutamic acid (ONX-0801).Type: GrantFiled: July 15, 2011Date of Patent: August 19, 2014Assignee: ONYX Pharmaceuticals, Inc.Inventors: James Alan Kerschen, Alexander James Bridges, Sean Mark Dalziel, Olivier Dapremont, Hyunjung Kim, Andrew S. Thompson, James Robert Zeller
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Publication number: 20140093630Abstract: The present invention provides compositions comprising sucralose and 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1H)-one or salts, solvates, and/or esters thereof and methods of making the compositions by spray drying. The present invention also provides ingestible compositions comprising compositions of the present invention and methods of making such foods. The present invention also includes a process of preparing 2-amino-thiophene derivatives, which are key intermediates for preparing 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1H)-one.Type: ApplicationFiled: March 25, 2013Publication date: April 3, 2014Applicant: SENOMYX, INC.Inventors: Rhondi Shigemura, Carolyn Podgurski, Boriruck Kitisin, Maria Suparno, Jennifer Ward, Thitiwan Lebien, Kevin Wirtz, James Robert Zeller
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Publication number: 20140031387Abstract: Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.Type: ApplicationFiled: July 25, 2013Publication date: January 30, 2014Applicant: SARcode Bioscience Inc.Inventors: James Robert Zeller, Sripathy Venkatraman, Elisabeth C. A. Brot, Subashree Iyer, Michael Hall
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Publication number: 20130345423Abstract: A new method for the synthesis of L-Glutamyl-?-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido)butanamido)pentanedioic acid, 1 are provided. Also provided is an efficient method for the isolation and purification of the trisodium salt of the abovementioned acid, 2, in a form suitable for long term storage and use in a parenteral dosing form.Type: ApplicationFiled: December 19, 2011Publication date: December 26, 2013Applicant: Onyx Pharmaceutical, Inc.Inventors: James Alan Kershen, Thomas Elliott Jacks, Andrew S. Thompson, Alexander James Bridges, Milind D. Choubal, Sean Mark Dalziel, James Robert Zeller
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Publication number: 20130211082Abstract: A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N-{N-{4-[N-((6S)-2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-L-?-glutamyl}-D-glutamic acid (ONX-0801).Type: ApplicationFiled: July 15, 2011Publication date: August 15, 2013Applicant: ONYX Pharmaceuticals, Inc.Inventors: James Alan Kerschen, Alexander James Bridges, Sean Mark Daizlel, Olivier Dapremont, Hyunjung Kim, Andrew S. Thompson, James Robert Zeller
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Patent number: 8440676Abstract: The present invention provides compositions comprising sucralose and 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1H)-one or salts, solvates, and/or esters thereof and methods of making the compositions by spray drying. The present invention also provides ingestible compositions comprising compositions of the present invention and methods of making such foods. The present invention also includes a process of preparing 2-amino-thiophene derivatives, which are key intermediates for preparing 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1H)-one.Type: GrantFiled: January 13, 2012Date of Patent: May 14, 2013Assignee: Senomyx, Inc.Inventors: Rhondi Shigemura, Carolyn Podgurski, Boriruck Kitisin, Maria Suparno, Jennifer Ward, Thitiwan Lebien, Kevin Wirtz, James Robert Zeller
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Publication number: 20120177584Abstract: The present invention provides compositions comprising sucralose and 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1H)-one or salts, solvates, and/or esters thereof and methods of making the compositions by spray drying. The present invention also provides ingestible compositions comprising compositions of the present invention and methods of making such foods. The present invention also includes a process of preparing 2-amino-thiophene derivatives, which are key intermediates for preparing 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1H)-one.Type: ApplicationFiled: January 13, 2012Publication date: July 12, 2012Applicant: SENOMYX, INC.Inventors: Rhondi SHIGEMURA, Carolyn Podgurski, Boriruck Kitisin, Maria Suparno, Jennifer Ward, Thitiwan Lebien, Kevin Wirtz, James Robert Zeller
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Patent number: 8119821Abstract: The present invention provides compositions comprising sucralose and 4-amino-5,6-dimethylthieno [2,3-d]pyrimidine-2(1H)-one or salts, solvates, and/or esters thereof and methods of making the compositions by spray drying. The present invention also provides ingestible compositions comprising compositions of the present invention and methods of making such foods. The present invention also includes a process of preparing 2-amino-thiophene derivatives, which are key intermediates for preparing 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1H)-one.Type: GrantFiled: February 6, 2009Date of Patent: February 21, 2012Assignee: Senomyx, Inc.Inventors: Rhondi Shigemura, Carolyn Podgurski, Boriruck Kitisin, Maria Suparno, Jennifer Ward, Thitiwan Lebien, Kevin Wirtz, James Robert Zeller
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Publication number: 20090292010Abstract: The present invention provides compositions comprising sucralose and 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1H)-one or salts, solvates, and/or esters thereof and methods of making the compositions by spray drying. The present invention also provides ingestible compositions comprising compositions of the present invention and methods of making such foods. The present invention also includes a process of preparing 2-amino-thiophene derivatives, which are key intermediates for preparing 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1H)-one.Type: ApplicationFiled: February 6, 2009Publication date: November 26, 2009Inventors: Rhondi Shigemura, Carolyn Podgurski, Boriruck Kitisin, Maria Suparno, Jennifer Ward, Thitiwan Lebien, Kevin Wirtz, James Robert Zeller
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Patent number: 5693845Abstract: Novel cyanocycloalkylacetic acids and esters as well as salts thereof and in particular 1-cyanocyclohexaneacetic acid and ethyl 1-cyanocyclohexaneacetate are described which are useful as intermediates in a process for the preparation of cyclic amino acids.Type: GrantFiled: March 6, 1992Date of Patent: December 2, 1997Assignee: Warner-Lambert CompanyInventors: Rex Allen Jennings, Don Richard Johnson, Ronald Everett Seamans, James Robert Zeller